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Opportunité en vedette

Toronto Psoriatic Arthritis Screening (TOPAS2) Questionnaire

University Health Network

A clinical tool to identify psoriatic arthritic patients The Toronto Psoriatic Arthritis Screening questionnaire (ToPAS2) was developed as a tool to screen for psoriatic arthritis (PsA) in patients with psoriasis as well as in the general population. Thus, it differs from PsA-specific screening tools and may be used to screen for PsA in epidemiologic and family investigations
Opportunité en vedette

Mobile App for Motivation Deficits in Schizophrenia

Centre for Addiction and Mental Health

Our scientists have developed a mobile app to objectively assess and encourage motivated behaviour, specifically goal-directed activity, which involves setting and completing plans and goals. The app allows for geo-location sensing that captures real-world behaviour and is connected to a reminder system that prompts the individual to pursue their goals. This app is geared primarily towards schizophrenia patients, as pronounced motivation deficits hinder many individuals with this illness....
Opportunité en vedette

Early Diagnostic Marker for Treatment Response in Rheumatoid Arthritis

University Health Network

Validated protein markers or phosphosignatures discovered in peripheral blood samples of RA patients and in animal models that predict RA, monitor disease progression and response to therapeutics In recent years there has been a burgeoning of biologic therapeutics for the treatment of Rheumatoid Arthritis (RA). There are currently 6 classes of biologics available for therapeutic use, each targeting a different immune-inflammatory pathway: TNF inhibitors, IL-1 receptor antagonists, B-cell...
Opportunité en vedette

Anti-Cancer T Cells and Their Preparation

University Health Network

A novel method to enhance efficacy of cell therapy modality involving T cell populations The role of each of the subtypes of T-cells in an immune response remains elusive. We have developed a novel method to modulate Tc22 lineage T cells from a population of CD8+ T cells that can impact the outcome of an immunotherapy treatment regimen. The method involves: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population...
Opportunité en vedette

STOP-Bang Tool

University Health Network

An innovative clinical tool for screening patients with obstructive sleep apnea Obstructive sleep apnea (OSA) is the most prevalent sleep-breathing disturbance, affecting 24% of men and 9% of women in the general population. An estimated 82% of men and 92% of women with moderate-to severe OSA have not been diagnosed. Investigators at UHN have developed a clinical tool that enables a physician to screen patients with OSA (www.stopbang.ca). The set of specific questions are well designed to...
Opportunité en vedette

Diagnostics for Intellectual Disability

Centre for Addiction and Mental Health

Our scientists have discovered a nonsense mutation in the TRAPPC9 gene and a missense mutation in the NSUN2 gene that allows for the direct diagnosis of intellectual disability with a predictive value of nearly 100%. These markers would strengthen the genetic testing menu of a diagnostic company, and may support therapeutic interventions for intellectual disability.
Opportunité en vedette

The Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)

University Health Network

A clinical impairment measure for the upper limb for use after tetraplegia The GRASSP measure is a) for use by clinicians in the clinical setting as a clinical outcome measure, b) researchers in the clinical/research setting as a primary or secondary outcome measure, and c) academics who are involved in investigator-driven research. GRASSP development has been a staged process with a number of different research groups and funding agencies involved. The GRASSP is a clinical impairment...
Opportunité en vedette

Biomarkers for Diseases Involving Chronic Low Back Pain

University Health Network

Elevated level auto-antibodies against noggin (NOG-N54) and sclerostin (SOST-S146) immune complexes in Ankylosing Spondylitis patient sera With up to 1% of the general population affected, Ankylosing Spondylitis (AS) is an under-recognized and debilitating chronic disease which affects predominantly young men in their 20’s. The chronic inflammation in AS causes excessive bony formation that can lead to irreversible loss of spinal mobility and long term disability. Chronic lower back pain can...
Opportunité en vedette

Genetic Test for Predicting Risk of Suicide

Centre for Addiction and Mental Health

Suicide claims over a million lives each year with 20 suicide attempts for each attributable death. Suicide has a prominent genetic component, and attempts tend to occur more often within families. Our test is based on obtaining a genetic sample from a subject and identifying whether they are at risk for suicide by identifying one or more genetic markers associated with it. Two complementary sets of genetic markers are included, which may be used separately, or combined into a broader panel....
Opportunité en vedette

Treatment of Insulin-Resistant Modulation of Gut Immunity and Intestinal Epithelial Function

University Health Network

New use of 5-ASA for glucose management Management of obesity and associated metabolic abnormalities requires new and efficient approaches. Researchers at UHN have developed a new method of management of glucose levels which utilizes 5-ASA. It has been shown that 5-ASA has an anti-inflammatory effect on the gut immune cell population in the colon and small bowel of mice fed a high-fat diet. The tendency for obese patients to have increased levels of inflammatory immune cells including Tbet+,...