Projets de recherche récents

Exploring the chemistry of ferrocene bioconjugates.

2016/17-2019/20 • $300,000 • PI
This NSERC discovery grant proposal focuses on ferrocene-peptide conjugates, their properties in solution and on surfaces, including their electrochemical and materials properties. In particular, we are exploiting the ability of ferrocene peptides to associate to form gel materials based on a...

Synthesis of Modified Nucleotide Triphosphates for Enzymatic DNA Synthesis**

2018/19 • $25,000 • PI
DNA sequencing technology has dropped the price of reading DNA over 10,000 times in 10 years. The bottleneck of synthetic biology is now writing (i.e. synthesizing) DNA. Startups in three major economies (US, France, UK) are working on next-generation enzymatic DNA synthesis technology to...

Development of an electrochemical sensor for monitoring drug binding

2016/17 • $25,000 • PI
As the leading form of dementia, Alzheimers disease is a healthcare priority in Ontario and world-wide. There is still no cure,because there is a serious lack of understanding in interaction of biomolecules implicated in the progression of Alzheimer's disease. Based on our ability to monitor...

Ferrocene peptides conjugates: Exploring structural diversity in solution and on surfaces

2010/11-2015/16 • $540,000 • PI
The overall thrust of our research program is aimed at developing the chemistry of bioorganometallic peptide conjugates with a focus on understanding their structural properties in solution and how they relate to structural properties when supported on surfaces. In this research program, the...

Electrochemical method for monitoring kinase activity

2010/11-2011/12 • $99,500 • PI,CO
Kinases are enzymes that are involved in regulating key cell functions. The reaction catalyzed by kinases is the transfer of a phosphate group from adenosine triphosphate to a hydroxy amino acid. Their activity is carefully controlled and uncontrolled activation of these enzymes has been linked...