Raffi Karshafian

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Projets de recherche récents

Interaction of ultrasonically-stimulated microbubbles with biological membranes

2015/16-2019/20 • $110,000 • PI
Ideally, therapeutic drugs would be delivered entirely to the diseased tissue, sparring healthy tissues. Of particular interest to our group is the application of sound energy at megahertz frequencies in combination with microbubbles, tiny bubbles smaller than red blood cells, to selectively...

Development of treatment planning platform for ultrasound stimulated microbubble therapy

2016/17-2018/19 • $416,060 • PI,CO,Other
Our group has discovered that by combining ultrasound and microbubbles, the vasculature of tumors can be made exquisitely sensitive to radiation therapy. Therefore, this approach holds considerable promise for enhancing the effectiveness of radiation treatments. However, translating this basic...

Development and testing of in vitro companion assay for novel hypoxia-activated mitochondrial prodrugs****

2018/19 • $25,000 • PI
Cyclica has developed a new technology, termed Differential Drug Discovery (DDD), to design single molecules capable of targeting multiple proteins simultaneously and retain drug like characteristics. The project will design tumour specific pro-drugs to target mitochondrial respiration. To...

Mask aligner for a microfluidic soft lithography cleanroom

2017/18 • $148,447 • PI,CO
We are requesting a mask aligner for UV lithography processes in the new, class 10,000 clean-room , at the Institute of Biomedical Engineering, Science, and Technology (iBEST)--a partnership between Ryerson University and St. Michael's Hospital. The mask aligner is the most important equipment...

Multispectral imaging of microbubble formation during external oxygen supply in biofluid and biotissue model

2016/17 • $25,000 • PI
To date, the wound care worldwide faces a lot of challenges due to growing problem of antibiotic resistanceand complications leading even to limb amputations, and new treatment approaches are highly demanded.Usage of external oxygen supply may dramatically help in healing wounds. Development of...

Interaction dynamics and bioeffects of acoustically activated microbubbles with biological membranes

2010/11-2014/15 • $120,000 • PI
Ideally, therapeutic drugs would be delivered entirely to diseased tissues, sparring healthy tissue. However, existing therapeutic drugs generally interact with both diseased and healthy tissues. Treatment effectiveness of cytotoxic drugs such as chemotherapy depends on the extent to which their...

The Terry Fox New Frontiers Program Project in ultrasound for Cancer Therapy

2010/11-2013/14 • $2,704,744 • PI
We are proposing to develop and enhance the use of ultrasound techniques to improve cancer treatment. We will continue developing quantitative ultrasound methods to detect and track the progression of the effects of cancer therapies on cell death. In addition, we will develop novel...

Ultrasound mediated sterlization using ozonated water

2013/14 • $25,000 • PI
Sterilization and infection control practices are necessary to all dental and healthcare providers in order to maintain health and safety standards. It is particularly important to ensure that endotoxins are killed, to prevent post-surgical immune responses. The current sterilization techniques...

Biofouling control by ultrasound-induced cavitation within water treatment systems

2013/14 • $25,000 • PI
The efficient treatment of water is important to any entity that relies on water for daily business. A particularly big concern inwater treatment is fouling, specifically membranes, filters and even at the bottom of containers causing significant, sometimes irreversible problems. The treatments...

In situ quantification of gold nanoparticles using the total reflection X-ray fluorescence

2011/12 • $127,294 • PI,CO
This proposal is for the purpose of purchasing a total reflection X-ray fluorescence (TXRF) spectrometer, and associated equipment, for the purpose of the in situ low-level quantification of gold, in the form of gold nanoparticle, in cell cultures and tissues, a fundamental, and currently...

Portable ultrasound array electronic system

2011/12 • $25,000 • PI
Ultrasound technology is extensively used in non-destructive testing (NDT) of nuclear, petrochemical, defense, manufacturing and aerospace. The single element ultrasonic probe based NDT methods currently are limited in their sensitivity of detecting small discontinuities particularly when...

Parallel channel acquisition module for new ultrasound-based imaging technique development

2010/11 • $75,710 • PI,CO
Ultrasound imaging is one of the most commonly the used imaging modalities for both medical imaging and the non-destructive evaluation of materials. Most instruments use arrays of individual transducers ( typically 128) to initially form and then collect the ultrasound waves. Equipment...

Optimization of microbubble agent for improving chemotherapy with ultrasound-microbubble

2010/11 • $25,000 • PI
The application of therapeutic ultrasound to tissue in the presence of microbubble agents has been shown to increase permeability of biological membranes such as cell membranes and blood vessels. In oncology, the combination of ultrasound-microbubble and chemotherapy may potentially enhance its...

Towards Presonalized Cancer Therapy: Tumour Response Monitoring using Quantitative Ultrasound

2010/11 • $15,250 • PI,CO
We are studying methods to develop and enhance the use of ultrasound techniques to improve cancer treatment. We are proposing an international symposium that will expand and build on our previous track record of developing quantitative ultrasound methods to detect, quantify and track the effects...