Lyndon Jones

Contact via University of Waterloo

Principaux champs de recherche
Chercheur(e)s associé(e)s
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Projets de recherche récents

Training in Global Biomedical Technology Research and Innovation

2018/19-2019/20 • $439,800 • PI,CO
Aucun sommaire

Biomaterials to Reduce Ocular Surface Inflammatory Response

2017/18-2019/20 • $84,000 • PI
Biomaterials are materials that come into close contactwith living biological cells or fluids. Some of the best examples ofbiomaterials include heart valves, blood vessels, artificial jointreplacements, breast implants, intraocular lens implants (for use followingcataract surgery), and contact...

Cytation Cell Imaging Multi-Mode Reader

2016/17 • $144,236 • PI,CO
Summary of Proposal for Public Release The University of Waterloo requires a Cytation 5 Cell Imaging and Multi-Mode reader that combines automated digital microscopy with multi-mode microplate bioreader that is able to provide phenotypic cellular information and quantitative measurements of cell...

Characterization of Ocular Biomaterial Uptake & Release

2016/17 • $28,000 • PI
Biomaterials are materials that come into close contact with living biological cells or fluids. Some of the best examples of biomaterials include heart valves, blood vessels, artificial joint replacements, breast implants, intraocular lens implants (for use following cataract surgery), and...

Critical Addition of a Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) Mass Spectrometer for the University of Waterloo Mass Spectrometry Facility

2015/16 • $150,000 • PI,CO
Critical requirements for the successful mass spectrometric analysis of high molar mass (bio)materials/(bio)polymers are a high sensitivity and the ability to measure the molar mass accurately to > 100 kDa. The University of Waterloo Mass Spectrometry Facility (UWMSF) has state-of-the-art...

20/20: NSERC Ophthalmic Materials Network

2010/11-2014/15 • $4,220,600 • PI,CO
Vision, arguably the most critical of the senses, is dependent on healthy ocular tissues. Unfortunately, disease, aging and congenital defects affect the health of these tissues. 20/20: NSERC Network for the Development of Advanced Opthalmic Materials brings together 11 Canadian researchers from...

Characterization of hydrogel biomaterials and their interaction with components of the human tear film

2010/11-2014/15 • $200,000 • PI
Biomaterials are materials of natural or artificial origin that can mimic, store, or come into close contact with living biological cells or fluids. Biomaterials have exhibited steady growth over the past half century, particularly in the areas of medicine, biology, chemistry, pharmacy and...

Two-Dimensional Nano Liquid Chromatograph with Nanospray Source for ThermoFisher Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer

2014/15 • $149,961 • PI,CO
Biochemical analytical capabilities are essential for understanding molecular events in biological systems. Measured analytes can also serve as biomarkers or indicators of physiological adaptations to events such as growth and aging, but also challenges in regard to exercise and nutrition. Mass...

Upgrade of U of Waterloo's primary confocal microscope with state-of-the-art correlative microscopy for co-applicants in 11 departments

2014/15 • $144,912 • PI,CO
We request purchase of Zeiss "Shuttle and Find" technology which serves as the interface for state-of-the-art correlative microscopy. Zeiss "Shuttle and Find" allows the taking of fluorescent confocal microscope image and then overlay the same ultrastructural image with a Zeiss Merlin electron...

Multiplexed Immunoassay Platform to Quantify Cytokines in Biological Samples

2014/15 • $51,188 • PI,CO
The University of Waterloo requires a high-throughput system for evaluating markers of inflammation ('cytokines') that is able to provide the reproducibility, reliability, robustness, and accuracy required for conducting research on the efficacy and tolerability of new medical device materials...

Biointerface science: proteoglycan 4 (PRG4) with and without hyaluronic acid as a novel ocular surface boundary lubricant & contact lens coating

2012/13-2013/14 • $184,000 • PI,CO
Dry eye disease is a major health-care issue and drain on health-care resources worldwide, with symptoms of discomfort, damage to the ocular surface, and a significant reduction in quality of life, with no current therapeutically effective treatments. Cells at the ocular surface, which forms a...

Cell sorter for university facility

2013/14 • $150,000 • PI,CO
A Fluorescence Activated Cell Sorter (FACS) is a machine capable of separating specific individual cells from other cells based on the proteins that they express on their surface. The cell surface proteins used to distinguish these cells are tagged with a fluorescent dye prior to the separation,...

Silicone hydrogel contact lens based delivery system for glaucoma treatment

2010/11-2012/13 • $102,000 • PI,CO
Aucun sommaire

Effects of a low humidity environment and visual tasking on tear film protein composition

2012/13 • $25,000 • PI
Tears are a readily available body fluid that can be easily collected without causing any discomfort to the patient. The collected tears can be analyzed in the laboratory and the results obtained from this analysis have the potential to tell us a great deal about our health. Tear tests, such as...

Hyaluronic acid containing and releasing materials in contact lens applications

2011/12 • $125,000 • PI,CO
In soft contact lens applications, the deposition of tear film proteins onto the surface of or into the bulk of the hydrogels can lead to discomfort and can be associated with such complications as giant papillary conjunctivitis and bacteria adhesion. Discomfort has been cited as the primary...

Entry-level confocal microscope needed for 38 users in the Faculties of Science and Engineering at the University of Waterloo

2011/12 • $120,464 • PI,CO
The University of Waterloo desperately requires a second confocal microsope for its multi-user facility. There is only a single, multi-user confocal microscope serving the whole university. This single microscope has logged 10,632 hours of use since it was installed in 2004, and is booked solid...