Carlos Filipe

Contact via McMaster University

Principaux champs de recherche
Chercheur(e)s associé(e)s
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Projets de recherche récents

Paper-based diagnostic device for colorectal cancer detection

2017/18-2019/20 • $402,900 • PI,CO
Colorectal cancer (CRC) affects over a million people globally, resulting in ~600,000 deaths annually. Early detection of CRC can significantly reduce the mortality of CRC. When neoplastic lesions are found while they are locally contained, the 5-year survival rate is greater than 90%; when they...

Industrial wastewater treatment within the "design space" scientific framework

2017/18-2019/20 • $305,275 • PI,CO
The research program will develop new detection and treatment technologies for the processing of industrial wastewater (WW) from industrial and commercial facilities (ICFs). The industrial relevance of the work described in the project is overwhelmingly high - the Wastewater Systems Effluent...

Engineering Highly Functional Components for Low-Cost Sensors for Personal Use

2018/19-2019/20 • $92,000 • PI
The key objective of our research program is to establish new scientific and engineering principles that can be applied to create ultra-low cost (pennies) sensors that can be used by any untrained individual to monitor the safety of their drinking water and food. These sensors can be used in a...

A Portable DNA Testing Device for Conservation

2019/20 • $72,000 • PI,CO
The goal of this project is to develop an affordable (less than CAN$1.00 per assay) and simple-to-use paper-based device capable of extracting and identifying DNA from biological samples, in the field, in real time. The device can be employed by non-trained users without the need for access to...

DNAPrint: a pathogen-tracking paper sensor platform that integrates functional DNA with nanomaterials

2016/17-2018/19 • $672,000 • PI,CO
Many human diseases are linked to infections involving various pathogens. In addition, growing risks of bioterrorism pose on-going threats to public safety and security. Moreover, rapid evolution of antibiotic-resistant "superbugs" is becoming a pressing global concern. It has been recognized...

Achieving Thermal Stability for PnuVax's Protein-Conjugate Vaccines****

2018/19 • $25,000 • PI
PnuVax Incorporated is dedicated to the production of high-quality vaccines and biopharmaceuticals for the promotion of public health worldwide. PnuVax produces several vaccines, including the protein/conjugates Prevnarr used to prevent pneumonia. The ability to produce and formulate this...

Understanding and Manipulating Interactions of Molecules and Paper Surfaces Focusing on the Development of Low-Cost Tools for Preserving and Monitoring Water Quality

2013/14-2017/18 • $175,000 • PI
Imagine having a strip of paper that when dipped in water indicates if it is safe for drinking. Paper sensors are important in developed countries (such as Canada), but critical in the Developing World. This Grant will help us answer some scientific questions bringing us closer to having paper...

NSERC CREATE Biointerfaces Training Program

2011/12-2016/17 • $1,300,000 • PI,CO
Our understanding of the nature of the biological/material interface, or biointerface, impacts all materials in biological media from contact lenses to blood contacting materials to diagnostic test strips and new bioseparation media. The CREATE Biointerfaces Training Program will provide unique...

Validation and scale up of vaccine stabilization for ambient handling using a pullulan/trehalose

2016/17 • $125,000 • PI,CO
Developing a technique for safely storing and transporting vaccines is considered the "holy grail" in global health, with huge potential for positive social impact. Current systems rely on "cold" supply chains that are expensive, heavily regulated and require a stable source of energy, to ensure...

NSERC - SENTINEL - Bioactive Paper Strategic Network

2010/11-2015/16 • $7,594,000 • PI,CO
Bioactive paper that can detect and deactivate dangerous bacteria and viruses in food and water will deliver health benefits around the world. Bioactive Paper is a made-in-Canada concept articulated in the first phase (2005-2010) of the Sentinel Bioactive Paper Network, an NSERC strategic...

Microplate based method for the detection of biocides in wastewater

2015/16 • $25,000 • PI
Currently, Aevitas Inc does not have rapid screening test for the wastewater that is brought in for treatment at its facilities. This means that under current conditions, the testing process takes 6 hours, and the test results are often unreliable. In order to be competitive and keep up with the...

Assembling protein based structures in living cells and in vitro

2010/11-2012/13 • $63,510 • PI
Proteins, have wide ranging applications: from the food industry to health-care; as therapeutic agents and as part of devices used for diagnostic purposes. We will be working in the field of protein production- specifically protein expression, making use of the remarkable properties of two...



The present disclosure relates to methods for attaching bioactive agents to paper products by contacting the paper with a solution comprising colloid al support particles where said colloidal support particles are associated w ith bioactive agents. In specific embodiment of the disclosure, the colloida l support particles are functionalized poly(N-isopropylacrylamide) microgels . The disclosure further covers the bioactive paper produced by this method as well as uses thereof, in particular...
Applications connexes: CA20082683729, WO2008CA00696


Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from...
Applications connexes: CA20102763834, WO2010CA00802, EP20100779977


A method of preserving the one or more chemical and/or biological species in a polymer matrix comprising pullulan and trehalose is described. The method includes combining the one or more chemical and/or biological species, an aqueous pullulan and a trehalose solution and drying the resultant mixture to provide a solid polymeric matrix. A polymeric matrix comprising one or more chemical and/or biological species and its use, for example, on surfaces for food preparation, for food...
Applications connexes: CA20183021005