Brian Amsden

Contact via Queen's University

Principaux champs de recherche
Chercheur(e)s associé(e)s
Organisations associées

Projets de recherche récents

CONNECT! NSERC CREATE Program In Soft Connective Tissue Regeneration/Therapy

2015/16-2019/20 • $1,500,000 • PI,CO
The CONNECT Training Program will provide a unique, enriched, and multidisciplinary training opportunity to undergraduate and graduate students and post-doctoral fellows in the development of novel, effective treatment approaches for soft connective tissue injuries. In particular, we will be...

Design of polymers and bioreactors in the development of a tissue engineering strategy for degenerative disc disease

2015/16-2019/20 • $175,000 • PI
The major challenge addressed in the proposed program is the design, synthesis, and testing of new polymeric biomaterials and bioreactors to be used for the development of a new treatment for degenerative intervertebral disc disease. The intervertebral disc is the connective tissue between the...

Liquid degradable aliphatic polycarbonate as an injectable drug delivery vehicle

2019/20 • $125,000 • PI
Chronic pain afflicts over 100 million North Americans and the current treatments are only moderately effective. In particular, opioids are commonly subscribed for this purpose, which has resulted in widespread problems with abuse and addiction. Moreover, current common therapy requires daily...

NSERC CREATE Biointerfaces Training Program

2011/12-2016/17 • $1,300,000 • PI,CO
Our understanding of the nature of the biological/material interface, or biointerface, impacts all materials in biological media from contact lenses to blood contacting materials to diagnostic test strips and new bioseparation media. The CREATE Biointerfaces Training Program will provide unique...

Articular Cartilage Reconstruction

2014/15-2016/17 • $168,003 • PI,CO
Damage to the tissue that lines the surface of the bones of the knees, and that provide smooth joint motion, can ultimatelyprogress to form cracks and defects. These cracks and defects result in the pain associated with arthritis, and is calledosteoarthritis. We plan on developing a treatment...

Water-soluble polymers for use in stimuli-responsive materials, water treatment and flocculation of oil sands tailings

2016/17 • $150,000 • PI,CO
Research activity targeting the development of new technologies to promote sustainability, increased protection for the environment, reduced environmental impact and improvements to human health is resulting in increasing use of polymeric materials that are water-soluble. In contrast, most...

Bioreactors for biomechanical conditioning and evaluation of native and engineered tissues

2016/17 • $150,000 • PI,CO
Our interdisciplinary team of engineers and scientists is at the forefront of understanding how biomechanical forces regulate cell and tissue function and applying that knowledge to help grow a wide range of engineered cardiovascular and respiratory tissues. Biomechanical regulation of cells and...

A Micro-Mechanical Testing Instrument

2016/17 • $137,624 • PI,CO
We are requesting funds to purchase an instrument that can measure the stiffness and other mechanical properties of a wide range of polymer biomaterials as well as those of tissues and individual cells. Precise measurement of these properties are essential in order to design new polymer...

Biomimetic implant for orthopedic surgery

2013/14-2015/16 • $316,442 • PI
Spinal implants represent a significant global business with revenues at US$6.5B (2009). While current synthetic technologies have demonstrated clinical success, today's reality is that these implants are far inferior to natural bone. Recently, the search for a synthetic bone graft that performs...

20/20: NSERC Ophthalmic Materials Network

2010/11-2014/15 • $4,220,600 • PI,CO
Vision, arguably the most critical of the senses, is dependent on healthy ocular tissues. Unfortunately, disease, aging and congenital defects affect the health of these tissues. 20/20: NSERC Network for the Development of Advanced Opthalmic Materials brings together 11 Canadian researchers from...

NSERC CREATE Training program in Bone and Joint Health Technologies

2010/11-2014/15 • $1,500,000 • PI,CO
The CREATE Professional Research Training Programme in Bone and Joint Health Technologies will provide highly qualified personnel trained in the integration of engineering principles, biological sciences, and information technology to solve patient oriented clinical problems through research...

Injectable biodegradable polymers for local drug delivery

2010/11-2014/15 • $150,000 • PI
This proposal is an extension of ongoing projects in my research group on the development of biodegradable, injectable polymers for localized protein drug delivery. A major research focus in my research group is the development of an effective formulation of angiogenic growth factors to...

Peptide Synthesizer For Biomaterial Preparation

2014/15 • $71,525 • PI,CO
Canadian citizens aged over 65 years currently consume over 40% of the annual healthcare budget. Within the next 20 years, this segment of the population is expected to increase from 12% to 21%, with a comparable increase in healthcare expenditures. Consequently, dramatic increases in healthcare...

Flow cytometer for advanced cell characterization in tissue-engineering applications

2010/11 • $119,278 • PI,CO
The requested flow cytometry system will enable us to advance our research programs and make important progress towards the development of new strategies to promote tissue regeneration in a broad range of applications, including novel orthopaedic, reconstructive, and cardiac therapies. An...

Promotion of cartilage-to-cartilage healing

2010/11 • $86,934 • PI,CO
We are developing an innovative technique to treat osteoarthritis, the debilitating condition wherein loss of mobility results from degeneration of the cartilage in th joint. Currently, there are few surgical approaches available for the repair of these focal cartilage lesions. One of the most...



The invention provides liquid injectable copolymers of TMC and HTMC that are degradable in vivo. Degradation can be tailored by adjusting the amount of HTMC in the copolymer, the initial molecular weight of the copolymer, and the characteristics of the initiator used in its preparation. Specifically, the degradation rate increases as the amount of HTMC incorporated into the copolymer increases, as the molecular weight of the copolymer decreases, and as the hydrophobicity of the initiator...
Applications connexes: CA20183023330