Charles Deber

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Projets de recherche récents

Conformational transitions of membrane-spanning peptides

2016/17-2019/20 • $216,000 • PI
Conformational transitions of membrane-spanning peptides Embedded in the membranes of all living cells, membrane proteins are the molecular links between the inside and outside world. These proteins, which represent 20-30% of all human genes, and 70% of drug targets approved by the FDA in the...

Conformational transitions of membrane-spanning peptides

2011/12-2015/16 • $280,000 • PI
Proteins embedded in membranes comprise fully one-third of the human genome. They regulate the molecular traffic and information flow across biological membranes and, as such, represent attractive biomolecules for the study and/or modulation of processes in living cells. It is estimated that...

Core facility infrastructure for optimizing conditions for lipidic cubic phase-based membrane protein crystallization

2014/15 • $150,000 • PI,CO
Membrane proteins perform a variety of biological functions that are critical to the survival of bacteria, plants, and eukaryotes. Crystal structures of these membrane proteins have shed enormous insights into the functions of transporters, signal transduction receptors, and enzymes. However,...

Relationship of hydrophobicity and membrane permeability in macrocycles

2014/15 • $25,000 • PI
Encycle Therapeutics is a Canadian start-up company that uses a unique chemistry platform, developed by the laboratory of Dr. Andrei Yudin at the University of Toronto, to make novel, drug-like molecules called macrocycles. For these molecules to become effective drugs, Encycle needs to be able...

Hydrophobic standards for electrophoresis

2011/12 • $119,017 • PI
Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a protein analysis technique performed daily in research and medical diagnostic laboratories all over the world. This procedure separates proteins into spots on a gel plate, and nearly all of its uses require a reasonable...

Conformational transitions of membrane-spanning peptides

2010/11 • $38,250 • PI
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