Dinesh Christendat

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Projets de recherche récents

Functional analysis of shikimate pathway gene duplicates

2015/16-2019/20 • $225,000 • PI
This application focuses on the functional annotation of shikimate pathway gene duplicates in plants and microbes. Specifically, we will investigate the function of plant shikimate kinase and microbial shikimate dehydrogenase gene duplicates. We have identified two shikimate kinase gene...

High resolution characterization of macromolecular structure and dynamics

2016/17 • $145,571 • PI,CO
Funds requested in this NSERC Research Tools and Instruments (Category 1) grant application will be used to purchase a state-of-the-art and new-to-market Size Exclusion Chromatography Multi-Angle Static Light Scattering (SEC-MALS) system and to upgrade a multiuser analytical ultracentrifugation...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...

Regulation of Arabidopsis shikimate pathway

2013/14 • $43,810 • PI
This application involves the functional annotation of enzymes of the shikimate pathway. The shikimate pathway produces precursors for the synthesis of the aromatic amino acids phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp). They are used by plants to synthesize many aromatic...

Regulation of the shikimate pathways in Arabidopsis

2010/11-2012/13 • $131,430 • PI
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