Projets de recherche récents

Optical blur on the retina of eye

2015/16-2019/20 • $120,000 • PI
The two directions of the research are A) to study the eye’s optics in normal and abnormal development; B) to image, in the retina, proteins associated with neuron damage as markers of age-related changes. Aims in this period are to: A1) determine how optical components alter with eye length, to...

Novel non-invasive imaging of amyloid in the retina of the eye as a predictor of amyloid in the brain in Alzheimer's disease

2016/17-2017/18 • $406,291 • PI,CO
Alzheimers disease (AD) currently cannot be cured and is often not diagnosed in its early stages. The disease has a largeimpact on patients as well as their families, caregivers and society as a whole. Probable AD is currently diagnosed by clinicalevaluation, including cognitive testing and by...

Optical image quality on the retina of the eye

2010/11-2014/15 • $210,000 • PI
Firstly, in eye development, we wish to understand the role of short and long term optical changes. We will a) characterize the optical signals to eye growth; b) model i) normal and abnormal growth and ii) the daily fluctuation of optical properties and c) determine the mechanisms which underlie...

Upgrade of U of Waterloo's primary confocal microscope with state-of-the-art correlative microscopy for co-applicants in 11 departments

2014/15 • $144,912 • PI,CO
We request purchase of Zeiss "Shuttle and Find" technology which serves as the interface for state-of-the-art correlative microscopy. Zeiss "Shuttle and Find" allows the taking of fluorescent confocal microscope image and then overlay the same ultrastructural image with a Zeiss Merlin electron...

Novel Diagnostic Methods for Imaging Amyloid Beta in the eye in association with alzheimer's disease

2012/13-2013/14 • $245,026 • PI,CO
There is no cure and no early detection method broadly available for Alzheimer's disease (AD). Definite diagnosis is only after death. AD has a large negative impact on individual health and an enormous cost to society. Early diagnosis and improved disease tracking lead to earlier and better...

Magnetically deformable mirrors for competitive manufacturing and biomedical imaging

2010/11 • $182,407 • PI,CO
The primary objective of this proposal is to bring a new type adaptive optics (AO) mirror, pioneered by us, to practicality. The strong, multidisciplinary team will develop a new device in a novel application of AO in the manufacture of optical devices. A second mirror will be built and tested...

Localizing light in the eye for diagnostic and therapeutic applications

2010/11 • $78,845 • PI,CO
The retina of the eye contains light sensitive cells, neurons and blood vessels. Recent adaptive optics technology to correct for the optical effects of eye tissue on light now enables light to be precisely focused onto these structures of the retina at the rear of the eye. As a result, very...

Brevets