Christopher Yip

Principaux champs de recherche
Chercheur(e)s associé(e)s
Organisations associées

Projets de recherche récents

Combinatorial Microscopies for Super-Resolution Imaging of Molecular and Cellular Dynamics

2015/16-2019/20 • $225,000 • PI
Understanding and ultimately controlling how molecules assemble into functional structures is critical in fields ranging from materials science and chemistry to structural and cell biology. We have a long-standing interest in understanding the fundamental mechanisms of self-assembly, ranging...

High resolution characterization of macromolecular structure and dynamics

2016/17 • $145,571 • PI,CO
Funds requested in this NSERC Research Tools and Instruments (Category 1) grant application will be used to purchase a state-of-the-art and new-to-market Size Exclusion Chromatography Multi-Angle Static Light Scattering (SEC-MALS) system and to upgrade a multiuser analytical ultracentrifugation...

An Enhanced Combinatorial Super-Resolution Microscopy Platform

2015/16 • $150,000 • PI,CO
RTI funding will be used to enhance the spatial, temporal, and spectral resolution of an exceptionally capable super-resolution combinatorial microscopy platform that combines the sub-nanometer 3-D resolution of scanning probe microscopy with super-resolution fluorescence microscopy. This latter...

Probing biomolecular assembly: Structure and dynamics

2010/11-2014/15 • $200,000 • PI
Controlling how molecules assemble to form functional structures and understanding the dynamics of these assembly processes is fundamental to efforts in fields ranging from materials science and chemistry to structural and cell biology. Arguably, determining the structural and conformational...

The effect of lyophilization on the structure of bone morphogenetic protein

2014/15 • $25,000 • PI
The physical, chemical, electronic, and in some cases, biological properties of a material are inherently tied to the molecular structure and conformation of its constituents. Understanding how manufacturing processes, including storage and reconstitution, may impact these characteristics is...

Characterizing the efficacy of novel industrial disinfectants by combinatorial microscopies

2014/15 • $25,000 • PI
Understanding how disinfectants work is critical for ensuring pathogen-free surfaces for both the food and health care industry. The present proposal is focused on developing methods and tools that can quantitatively determine how both model and novel disinfectants exert their action at...

Characterization of starch nanoparticle surface chemistry, aggregation, and gelation characteristics: Application of working model to new product developments

2014/15 • $12,500 • PI
EcoSynthetix has developed a novel polymer based on starch nanoparticles. The performance of this polymer, which is derived from renewable crop resources, has exceptional performance and is high-performance alternative to conventional petrochemical-based binding agents in paints, coating, and...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...

Characterization of starch nanoparticle surface chemistry, aggregation, and gelation characteristics: Correlating physico-chemical nanostructure to macroscopic performance.

2013/14 • $25,000 • PI
EcoSynthetix has developed a novel polymer based on starch nanoparticles. The performance of this polymer,which is derived from renewable crop resources, has exceptional performance and is high-performancealternative to conventional petrochemical-based binding agents in paints, coating, and...

Harnessing the therapeutic potential of carcinoembryonic antigen family receptors

2010/11-2011/12 • $149,500 • PI,CO
Aucun sommaire

Brevets