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Principaux champs de recherche
- Génie biomédical
- Santé publique, éducation et services sociaux
- Matériaux biomédicaux
- CANCER IMMUNOLOGY
- Competitive affinity release
- Produits pharmaceutiques administrables à l'homme
- Hydrogel brain implants
- INJECTABLE HYDROGELS
- Études pluridisciplinaires
- Intracranial T-cell expansion
- Local protein delivery
- Procédés et produits industriels
- Sciences des matériaux
- non-immunogenic materials
- Chimie macromoléculaire et des matériaux – autres (éléments non classés ailleurs)
- Protéines et peptides, acides aminés
- Technologie biomédicale
- Bi-specific T-cell engagers
Projets de recherche récents
2019/20 • $149,896 • PI,CO
As biofabrication and tissue engineering techniques have rapidly advanced in recent years, we are increasingly tasked to visualize complex engineered tissues and 3D biological explants with increasing levels of detail to keep up with the expanding frontier of biological inquiries. However,...
2015/16-2019/20 • $125,000 • PI
Biomaterials based strategies have the potential to improve human health by understanding and controlling the way cells behave with their environment, which will ultimately lead to the development of materials for the treatment of diseases. Cells are surround by a dynamic four-dimensional...
Integrated liquid chromatography-multiangle light scattering system to measure absolute masses and stoichiometries of biological assemblies in solution
2018/19 • $149,899 • PI,CO
This application requests a state-of-the-art size exclusion chromatography system integrated with multi-angle light scattering (SEC-MALS). SEC-MALS is capable of measuring absolute aggregate molecular weights (MWs) and radii of gyration (Rg) under physiological native solution conditions with...
Immunoengineering the brain with hydrogel-nanoparticle composites to improve glioblastoma immunotherapies
2018/19 • $125,000 • PI,CO
Cancer immunotherapies have shown great promise but remain ineffective against solid tumors due to transport barriers that prevent immunotherapeutic and cytotoxic (cancer killing) immune cells from accumulating in tumors. Transport obstacles are even more pronounced in brain and central nervous...
Enhanced LSPR sensitivity for OpenSPR detection of therapeutic antibodies and polymer antibody conjugates
2018/19 • $25,000 • PI
Therapeutic antibodies represent a growing class of drug that are particularly important for cancer immunotherapies. Due to biological transport barriers, many treatments fail due to the lack of antibodies reaching the disease site. Furthermore, large doses of antibodies are commonly...
2016/17 • $25,000 • PI
The development of tissue mimics from non-animal sources will greatly increase research productivity in biomedical sciences. Specifically, tissue mimics are being developed to increase drug screening efficiency, to better understand complex mechanisms of disease, and to create implantable...
Applications connexes: CA20172969564