Projets de recherche récents

Light-sheet microscopy for 3D bioimaging of engineered tissues and microphysiological systems

2019/20 • $149,896 • PI,CO
As biofabrication and tissue engineering techniques have rapidly advanced in recent years, we are increasingly tasked to visualize complex engineered tissues and 3D biological explants with increasing levels of detail to keep up with the expanding frontier of biological inquiries. However,...

Dynamic biomaterials to study, manipulate and screen cell-matrix interactions

2015/16-2019/20 • $125,000 • PI
Biomaterials based strategies have the potential to improve human health by understanding and controlling the way cells behave with their environment, which will ultimately lead to the development of materials for the treatment of diseases. Cells are surround by a dynamic four-dimensional...

Integrated liquid chromatography-multiangle light scattering system to measure absolute masses and stoichiometries of biological assemblies in solution

2018/19 • $149,899 • PI,CO
This application requests a state-of-the-art size exclusion chromatography system integrated with multi-angle light scattering (SEC-MALS). SEC-MALS is capable of measuring absolute aggregate molecular weights (MWs) and radii of gyration (Rg) under physiological native solution conditions with...

Immunoengineering the brain with hydrogel-nanoparticle composites to improve glioblastoma immunotherapies

2018/19 • $125,000 • PI,CO
Cancer immunotherapies have shown great promise but remain ineffective against solid tumors due to transport barriers that prevent immunotherapeutic and cytotoxic (cancer killing) immune cells from accumulating in tumors. Transport obstacles are even more pronounced in brain and central nervous...

Enhanced LSPR sensitivity for OpenSPR detection of therapeutic antibodies and polymer antibody conjugates

2018/19 • $25,000 • PI
Therapeutic antibodies represent a growing class of drug that are particularly important for cancer immunotherapies. Due to biological transport barriers, many treatments fail due to the lack of antibodies reaching the disease site. Furthermore, large doses of antibodies are commonly...

3D bioprinted cell seeded POEGMA hydrogels as tissue mimics

2016/17 • $25,000 • PI
The development of tissue mimics from non-animal sources will greatly increase research productivity in biomedical sciences. Specifically, tissue mimics are being developed to increase drug screening efficiency, to better understand complex mechanisms of disease, and to create implantable...



The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.
Applications connexes: CA20172969564