Ponnambalam Selvaganapathy

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Projets de recherche récents


2016/17-2019/20 • $400,000 • PI
Microfluidics has many potential applications among which the most exciting are in the areas of medical and environmental diagnostics, assays for drug discovery, and in construction of artificial organs. This research program is aimed at using microfluidic and microfabrication technologies to...

Microsystems for drug discovery and biological studies

2015/16-2019/20 • $235,000 • PI
Miniaturization of assays in genomics and proteomics led to dramatic improvements in their speed at significantly lower cost, facilitating an explosion in their use in a wide variety of applications. For instance, sequencing a genome costs 10,000$ today as opposed to 100 million$ a decade ago;...

Light-sheet microscopy for 3D bioimaging of engineered tissues and microphysiological systems

2019/20 • $149,896 • PI,CO
As biofabrication and tissue engineering techniques have rapidly advanced in recent years, we are increasingly tasked to visualize complex engineered tissues and 3D biological explants with increasing levels of detail to keep up with the expanding frontier of biological inquiries. However,...

Development of cost-effective and high-performance penetration resistant materials and gloves

2018/19-2019/20 • $138,885 • PI,CO
Personal protective equipment (PPE) and wearables such as gloves are used in a wide range of occupations including law enforcement, military, food processing, manufacturing, resource extraction and healthcare. The global body armor and PPE market was worth about US$3.8 billion in 2014 and is...

Aqueous chloramine sensors based on molecules acting as switchable dopant sites on graphene-like carbon films

2018/19-2019/20 • $120,000 • PI,CO
Water is fundamentally important to most aspects of our existence. One of the most important monitoring parameters of drinking water quality is the level of disinfectants. If their levels are too low, microorganisms can grow in the water, which are harmful to our health. If the disinfectant...

Reactive Silicone Inks for 3D Printing Using Microfluidic Mixers

2015/16-2017/18 • $549,500 • PI,CO
3D printing (additive manufacturing) is a disruptive technology making rapid inroads into commercial print-on-demand manufacturing and into the community. Silicones used in applications ranging from contact lenses to computer keyboard springs. They cure into rubbers too slowly to be used as...

Point of Care Device for Rapid Quantification of Cell-Free DNA with Application in Severe Sepsis

2016/17-2017/18 • $240,400 • PI,CO
Sepsis, the whole body response to infection, is associated with a high risk of intensive care unit admission, organ damageand death. Our clinical work has demonstrated that free DNA (cfDNA) released from cells into the bloodstream is a verystrong predictor of ICU death. The current technology...

Development of cost-effective label-free protein biosensors using magnetic bio-inks

2017/18 • $218,500 • PI,CO
Canada's increasing aging population is confronted by a lack of timely diagnosis for various autoimmunediseases with turnaround times varying from a few days to weeks, leading to rising healthcare costs withunfavorable economic and societal implications. Traditional methods for disease detection...

Microsystems for drug discovery and biological studies

2015/16-2017/18 • $120,000 • PI
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Development of a microfluidic ion exchange preconcentration module for heavy metals sensing in water

2017/18 • $25,000 • PI
This project develops a microfluidic preconcentration device that is critical to improve the sensitivity of heavymetal sensors which are used for monitoring the environment. Assessment of water quality at a remote settingrequires devices that are portable, inexpensive, user agnostic and accurate...

Universal point-of-care test device for the rapid diagnosis of infectious diseases

2014/15-2016/17 • $247,495 • PI,CO
Infectious diseases have become a major threat to public health, causing more than 13 million deaths per year, of whichapproximately 50% occur in developing countries. Clinicians rely on the laboratory to identify the pathogen responsible forthese diseases and initiate proper treatment, which...

Flexible Ultrahigh-Speed Camera for Improved Experimental Characterisation

2016/17 • $149,893 • PI,CO
The microscope as we know it today has become an indispensable tool across many fields of research. Since the first incarnations of the microscope began to see use in research in the mid 1600's, it has exponentially expanded the sphere of physical phenomena that can be inspected and measured,...

High-capacity multi-axis load cells to advance research on sustainable infrastructure

2016/17 • $141,860 • PI,CO
Building and maintaining sustainable high-performance infrastructure is a major challenge for Canada. A recent study commissioned by the Insurance Bureau of Canada found that a major earthquake will result in losses of more than C$60 billion in the Quebec City-Montreal-Ottawa corridor and nearly...

Feasibility of using shear thickening fluids to prevent needle stick injuries

2016/17 • $25,000 • PI
This project develops new knowledge in the use of shear thickening fluids and investigates its use as a potentialmaterial to be used in gloves to prevent needle stick injuries. Our partner, Ronco, is an Ontario based companyand is a leading manufacturer of gloves and other personal protective...

Development of a pumpless lung assist device which acts like an artificial placenta for neonates with respiratory failure.

2013/14-2014/15 • $273,356 • PI,CO
Respiratory failure is the major cause of morbidity among neonates with birth weights less than 1,500 g. Mechanicalventilation has dramatically improved neonatal outcome during the last decade. However, this approach is not effectiveenough in neonates with severe respiratory failure to prevent...

Microsystems for drug discovery and biological studies

2010/11-2014/15 • $215,000 • PI
Microfabricated Lab-on-Chip devices for genomics and proteomics have been widely researched and developed over the past decade and have gained significant acceptance among biological and biomedical researchers. The next grand challenge is the miniaturization of laboratory automation technologies...

High Power Ultrafast Fiber Laser for Studying Laser Bone Ablation

2014/15 • $143,000 • PI,CO
This proposal requests a high power ultrashort fiber laser for studies of laser bone ablation and fabrication of optofluidics devices. This technology develop finds applications in laser surgery instrumentation as well as environmental and biomedical sensors. Compared with conventional...

The use of the liquid scintillation counter and automated set-shifting apparatus for studying the brain

2014/15 • $60,771 • PI,CO
What kinds of brain abnormalities occur in adulthood as a result of abnormal brain development? How does the brain produce goal-directed behaviour and cognition? Can we use incredibly minute molecules, called nanoparticles, to increase the quantity of drugs reaching the brain? These are some of...

Feasibility of using direct mechanical micromachining to build microfluidic cartridges for capillary driven Point of Care diagnostic devices

2014/15 • $25,000 • PI
Blood analysis is an important parameter to diagnose a medical condition of a patient. Most blood tests are carried out in a local hospital which requires scheduling and waiting time. A hand held blood analyzer on the other hand has much benefit by providing these blood tests near the point of...

Placenta-chip for new biomarker discovery and production technologies

2014/15 • $25,000 • PI
This project develops a microfluidic device that is used to cultivate Placental cells for production of proteins such as hyperglycosylated-hCG that are used as important biomarkers in diagnostic assays. Our partner, Evik Diagnostics, is interested in developing a reliable supply of human...

Microfluidic high-throughput screening device for C. elegans movement based assays

2011/12-2013/14 • $220,250 • PI,CO
C. elegans is one of the most widely studied organisms that is of great importance in the study of molecularmechanisms underlying numerous biological and disease processes. Because C. elegans carries more than halfof human disease genes and utilizes many of the same mechanisms, the findings in...

Portable real-time water monitoring system

2010/11-2011/12 • $321,000 • PI,CO
The availability of safe drinking water is fundamental to health. Unfortunately, the sustainability of this precious resource is under threat from several factors including population growth, environmental degradation, and the looming challenge of climate change. As water resources get...

C. elegans microfluidic electrotaxis system

2011/12 • $73,873 • PI,CO
We are requesting funds to custom build a C. elegans Microfluidic Electrotaxis imaging and measurement System (CelMES). The system will be used to study the mechanism of neuronal-basis of locomotion and neurodegeneration in the nematode (worm) C. elegans. CelMES will be the first dedicated...

Feasibility study on NIR based detection of pharmaceuticals in water using microfluidic devices

2010/11 • $25,000 • PI
Water is a critical resource that is essential for the well being and viability of the population as well as the economy. One of the major emerging contaminant class in water is pharmaceuticals and other chemicals that are commonly used in households, collectively known as pharmaceuticals and...



A microinjection device for injecting a target cell with a reagent. The microinjection device includes a flexible substrate; a target supply channel formed in the flexible substrate for receiving the target cell; a reagent supply channel formed in the flexible substrate for receiving the reagent; a suction capillary mounted within a suction channel formed in the flexible substrate, the suction capillary providing suction to the target supply channel for immobilizing the target cell within...
Applications connexes: CA20092685615