Trevor Moraes

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Projets de recherche récents

Upgrade Advanced EPR/DEER Spectroscopy Facility

2019/20 • $150,000 • PI,CO
Electron paramagnetic resonance (EPR) and double electronelectron resonance (DEER) spectroscopy are important structural biology methods to obtain information on protein dynamics and protein conformations, which is complementary to cryo-electron microscopy (cryo-EM) and x-ray crystallography....

Phosphorylated Carbohydrate Transport Across the Bacterial Cell Envelope

2018/19-2019/20 • $116,000 • PI
Bacteria depend on the acquisition of a diverse set of nutrients from their hosts to engage in successful growth, colonization or pathogenesis. Commensal and/or pathogenic bacteria compete with host cells for substrates ranging from metals to vitamins. As this competition can influence the...

Phosphorylated-Carbohydrate Transport Across the Bacterial Cell Envelope

2017/18 • $28,000 • PI
Phosphorylated-Carbohydrate Transport Across the Bacterial Cell Envelope Bacteria depend on the acquisition of a diverse set of nutrients from their hosts to engage in successful growth, colonization or pathogenesis. Commensal and/or pathogenic bacteria compete with host cells for substrates...

High resolution characterization of macromolecular structure and dynamics

2016/17 • $145,571 • PI,CO
Funds requested in this NSERC Research Tools and Instruments (Category 1) grant application will be used to purchase a state-of-the-art and new-to-market Size Exclusion Chromatography Multi-Angle Static Light Scattering (SEC-MALS) system and to upgrade a multiuser analytical ultracentrifugation...

Investigating the mechanism of phosphate aquisition by Pseudomonas aeruginosa

2011/12-2015/16 • $205,000 • PI
Phosphate is an essential nutrient that is found in lipids, nucleic acids, proteins and sugars and is also key to many biological reactions that require ATP and/or signaling pathways that exploit protein phosphorylation. Thus, bacteria utilize a global regulatory circuit, the Pho regulon, to...

An Enhanced Combinatorial Super-Resolution Microscopy Platform

2015/16 • $150,000 • PI,CO
RTI funding will be used to enhance the spatial, temporal, and spectral resolution of an exceptionally capable super-resolution combinatorial microscopy platform that combines the sub-nanometer 3-D resolution of scanning probe microscopy with super-resolution fluorescence microscopy. This latter...

Core facility infrastructure for optimizing conditions for lipidic cubic phase-based membrane protein crystallization

2014/15 • $150,000 • PI,CO
Membrane proteins perform a variety of biological functions that are critical to the survival of bacteria, plants, and eukaryotes. Crystal structures of these membrane proteins have shed enormous insights into the functions of transporters, signal transduction receptors, and enzymes. However,...

Examining Biomolecular Interactions using Microscale Thermophoresis

2013/14 • $150,000 • PI,CO
As part of a team of 10 structural biologists at the University of Toronto (spanning several departments and faculties), we use biophysical tools such as Atomic Force Microscopy, NMR spectroscopy, X- ray crystallography and electron cryomicroscopy to analyze the biomolecular interactions between...

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