Kjetil Ask


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Projets de recherche récents

gp130 cytokines and IL-33 in progression to chronic lung fibrosis

2017/18-2019/20 • $421,707 • PI,CO
Buildup of scar tissue in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) results in local events in lungs that compromise lung function. These include the accumulation of inflammatory cells and decreases in oxygen exchange, and IPF patients have an average survival time of 3...

Targeting endothelial cell dysfunction and vascular remodelling to stop progression of advanced pulmonary fibrosis

2019/20 • $149,940 • PI,CO
Lung fibrosis affects approximately 14,000 Canadians, about half of them dying within 3-4 years. The disease origin is often unknown. It is characterized by relentless scarring, causing stiffening of the lungs and progressive shortness of breath until death. Limited treatment options are...

Designing Highly Porous Drug-Impregnated Polymer Scaffolds Using Pressurized Gas Expanded Liquids for the Treatment of Lung Fibrosis and Wound Infections

2019/20 • $92,948 • PI,CO
Highly porous materials offer significant advantages in many biomedical applications based on their extremely high surface areas. In particular, for the delivery of drugs with low water solubility, the high surface area provided by highly porous scaffolds offers unique opportunities for...

Designing Highly Porous Drug-Impregnated Polymer Scaffolds Using Pressurized Gas Expanded Liquids for the Treatment of Lung Fibrosis and Wound Infections

2019/20 • $92,947 • PI,Other
Highly porous materials offer significant advantages in many biomedical applications based on their extremely high surface areas. In particular, for the delivery of drugs with low water solubility, the high surface area provided by highly porous scaffolds offers unique opportunities for...

Role of the unfolded protein response in hypertension induced end organ damage.

2014/15-2016/17 • $323,142 • PI,CO
High blood pressure puts more people at risk of dying from disease than anything in the world. It causes many of these deaths by making people's heart, kidneys or breathing fail due to fluid build up in their lungs. It also causes stroke. How high blood pressure causes this damage to these...

Selective inhibition of Unfolded Protein Response-mediated XBP-1 splicing to prevent progression of inflammatory and fibrotic chronic lung disease

2015/16-2016/17 • $105,000 • Scholarship/Fellowship,Other
The molecular mechanisms that contribute to chronic tissue scarring and inflammation in the lung remain to be fully understood. Recent evidence has shown that mechanisms involved in protein homeostasis are associated with chronic fibrotic and inflammatory lung diseases. The endoplasmic reticulum...

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