Michael D. Cusimano

Contact via St. Michael's Hospital

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Projets de recherche récents

PROphylaxis for venous ThromboEmbolism in Severe Traumatic brain injury (PROTEST): a Double-blind Randomized Controlled Trial

2018/19-2020/21 • $1,938,143 • PI,CO
Severe traumatic brain injury is common, potentially lethal, and can result in severe and irreversible disability. It is also often associated with potentially life-threatening complications during the early period following the injury, when patients are critically ill and receiving life...

Positron Emission Tomography Imaging Monoamine Oxidase B in Major Depressive Disorder With and Without Comorbid Traumatic Brain Injury

2017/18-2020/21 • $545,539 • PI,CO
50% of clinical depression cases are treatment resistant, most likely because clinical depression is composed of multiple biological changes, and these changes may vary from one case to another. We think the approach to overcoming treatment resistance is to discover these key biological changes...

Canadian Traumatic brain injury Research Consortium (CTRC)

2015/16-2019/20 • $1,824,513 • PI,CO,Other
Traumatic brain injury (TBI) is the most common cause of death in the first half of life and the most frequent cause of long term handicaps for Canadians of all ages. TBI can be quite variable. Individuals who experience the mild form, called concussion, can appear normal on the outside but be...

Identification of the biomechanical and biomarker predictors of persistent concussive syndrome

2016/17-2018/19 • $90,000 • Scholarship/Fellowship,Other
Concussion has been demonstrated to be either a short term brain injury whose symptoms resolve within weeks, or can result in debilitating long term symptoms that are present for a much longer period of time. This research examines the differences in impact biomechanics, neurocognitive scores,...

Revision and Validation of the Critical-Care Pain Observation Tool in critically ill adults with brain injury

2011/12-2015/16 • $402,672 • PI,CO
Brain injury such as bleeding in the brain, brain trauma, stroke, or brain tumors often require a stay in the Intensive Care Unit. During this time, patients may be unable to self-report pain. Pain left untreated can lead to poor healing of wounds, heart and breathing difficulties, and might...

Trauma System Development in Canada: Overcoming the challenges of geography through an evaluation of structure and process.

2010/11-2014/15 • $1,994,649 • PI,CO
Severely injured patients have a lower mortality risk if cared for in a trauma centre. Thus survival is dependent on an integrated regional system of care to assure these patients are identified, supported and rapidly transported to a trauma centre. Trauma centres are only located in urban...

CIHR Team in Traumatic Brain Injury and Violence

2010/11-2014/15 • $1,887,348 • PI,CO
Traumatic Brain Injury (TBI) accounts for 50% or more of all trauma deaths, and an estimated 2% of the population live with lifelong disabilities resulting from TBI. There appears to be a direct link between TBI and violence, which itself is a major issue for Canadians. The goal of the research...

Validation of non-invasive rapid eye movements measurement as screening tool for mild traumatic brain injury

2012/13-2014/15 • $250,140 • PI,CO
Mild traumatic brain injury (mTBI; including concussion) is a common problem. Properly identifying mTBI is important in order to prevent premature return to activities and to start timely and appropriate treatments. Presently there are no validated, portable tools available to objectively...

Optical Coherence Tomography for Intraoperative Imaging During Skull Base Neurosurgical Procedures

2010/11-2013/14 • $379,765 • PI,CO
Newly diagnosed and mortality rates from pituitary tumors and cerebral aneurysms occur at a rate of ~325 (~220 deaths) and ~3,300 (~2,200 deaths) per year, respectively. Combined these central nervous system diseases present a significant health care burden to Canada. This research proposal...

Clarifying the link between traumatic brain injury and homelessness: a planning workshop

2011/12 • $24,837 • PI,CO
Homelessness and poverty are among the most important social problems in Canada today. Recent studies have shown that over half of homeless people have had a traumatic brain injury during their lifetime. Experiencing a traumatic brain injury can leave a person with long-term physical, emotional...

Planning of an innovative technology-based approach to the treatment of depression following traumatic brain injury

2011/12 • $24,702 • PI,CO
Depression is one of the most common mental health symptoms after traumatic brain injury. Since patients with traumatic brain injury depression experience poorer recoveries than those without, depression should be treated quickly to help patients feel better faster. Internet-delivered therapies...

Cannabis and traffic collisions: A case crossover study of patients presenting to tertiary care centres in Toronto and Halifax

2010/11 • $179,086 • PI,CO
Impaired driving is a leading cause of morbidity and mortality in Canada, and is an important issue to researchers, policymakers, and the public. Epidemiological evidence points to the profound effect of alcohol on road safety, and a number of important initiatives to combat this problem have...