Alison E. Fox-Robichaud


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Projets de recherche récents

The Canadian Network of COVID-19 Clinical Trials Networks

2020/21 • $6,000,000 • PI,CO,Other
Nearly 350,000 Canadians have been diagnosed with COVID-19 infection. In Canada, the elderly have been particular vulnerable, with long-term care homes experiencing the greatest burdens of illness and mortality. Civil society and our usual social fabric have been torn, due to illness, loss,...

Canadian COVID-19 Prospective Cohort Study (CanCOV)

2020/21 • $2,687,475 • PI,CO,Other
The Canadian COVID-19 Prospective Cohort Study (CANCOV) is the first Canadian study to provide a comprehensive evaluation of early to 1-year outcomes in 2000 patients with COVID-19 infection and their family caregivers. This study will be conducted in Quebec, Ontario, Alberta and British...

SQUEEZE Trial: a trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal directed fluid sparing strategy vs. usual care

2016/17-2020/21 • $1,992,464 • PI,CO
Background: Sepsis arises when the body's response to an infection damages its own tissues and organs. Septic shock remains one of the most significant and potentially preventable causes of death in children worldwide. The American College of Critical Care Medicine has guidelines explaining how...

CYCLE: An international, multi-centre, randomized clinical trial of early in-bed cycling for mechanically ventilated patients

2018/19-2020/21 • $1,537,081 • PI,CO
Background: Critically ill patients in the intensive care unit (ICU) are the sickest patients in hospital, and need advanced life support. People who survive their critical illness are typically very weak and disabled. Over half of them have severe leg weakness impairing their quality of life...

Canadian Sepsis Research Network: Improving Care Before, During and After Sepsis.

2019/20-2020/21 • $1,520,001 • PI,CO,Other
Sepsis is the life-threatening response to infection. It affects everybody, especially children, seniors and those with other health issues. Sepsis costs the Canadian healthcare system over $1.5 billion every year, and causes more deaths than breast, bowel and lung cancer put together. Survivors...

COVID-19: Comprehensive biomarker analysis for prediction of clinical course and patient treatment outcomes (COVID-BEACONS)

2020/21 • $1,173,325 • PI,CO
The COVID-19 pandemic has taken the world by storm. In Canada alone, there are more than 60,000 confirmed cases and more than 5,000 deaths. Despite its global impact, there are no specific therapies. While most patients display mild or no symptoms, a significant number result in severe disease,...

Canadian Adaptive Platform Trial in Intensive Care (CAPTIC) Program

2018/19-2020/21 • $1,161,939 • PI,CO,Other
More than 250,000 Canadians are admitted to an ICU each year. While most survive, the mortality rate of 10% remains high, and survivors often experience severe long term disability and a reduced quality of life. Improved ICU care has come largely from using available treatments more effectively,...

Transfusion in traumatic brain injury (TSiTBI Trial)

2016/17-2020/21 • $1,105,911 • PI,CO
The incidence of anemia (a decrease in the quantity or quality of red blood cells) is frequent among critically ill patients. Because red blood cells, through the molecules of hemoglobin, are oxygen carriers, a decrease in the availability of oxygen to the different organs is often to fear. In...

Automated Oxygen Titration, Monitoring and Weaning in patients with infectious pneumonia requiring oxygen - impact on the number of interventions for healthcare workers. An innovative device to manage patients with COVID-19 pneumonia. COVID study (Closed-Loop Oxygen to Verify that healthcare workers Interventions Decrease during pneumonia)

2020/21 • $829,476 • PI,CO,Other
Automated oxygen titration, weaning and monitoring (FreeO2 device) may be a solution to reduce the number of interventions of healthcare workers (which is directly related to the risk of transmission of COVID-19. There is a high risk of transmission of COVID-19 to healthcare workers. in a recent...

RECOVER Program: A Care Continuum after Critical Illness

2019/20-2020/21 • $504,308 • PI,CO,Other
Critical illness is a catastrophic life event for the patient and their family. Over 250,000 Canadians are admitted to an intensive care unit (ICU) each year. These admissions cost 0.2% of the Gross Domestic Product, or $4 billion annually. Most of these patients will require mechanical...

Co-designing a Patient and Family Caregiver-Oriented Transitions in Care Bundle

2019/20-2020/21 • $503,540 • PI,CO,Other
Patients in the intensive care unit (ICU) are very sick. When a patient leaves the ICU they may have a change in their health that is new to them and their family members, such as new medical problems or new medications. When a patient leaves an ICU they can move to another part of the hospital...

The Role of Active Deresuscitation After Resuscitation (RADAR): A pilot randomized clinical trial

2019/20-2020/21 • $382,500 • PI,CO
Life support measures provided to critically ill patients in an intensive care unit (ICU) include the infusion of fluids directly into a vein (intravenously - IV). IV fluids support the circulation when a patient is unable to drink, and provide a means of delivering medications, and many liters...

Fluids in Septic Shock (FISSH): a randomized controlled trial.

2020/21 • $327,855 • PI,CO
Severe infection can lead to many complications within the human body including low blood pressure, which is called septic shock. Rates of death for those with septic shock can be as high as 40%. The main treatments for septic shock are intravenous antibiotics and intravenous (IV) fluids. There...

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Comparative Effectiveness Trial (FLUID)

2018/19-2020/21 • $306,530 • PI,CO
Patients who are acutely ill and admitted to a hospital will likely receive salt fluids to help improve blood pressure, and maintain vital organs (ex: heart and kidney) and the circulatory system. Two salt fluids most commonly used for these purposes are normal saline and Ringer's lactate. Both...

Understanding and managing the effects of COVID-19 restricted visitation policies on the families and healthcare providers of critically ill patients

2020/21 • $298,769 • PI,CO,Other
There is worldwide spread of the coronavirus (COVID-19). Right now there is no vaccine or cure for the coronavirus. This means that most people can get sick with the coronavirus. Many hospitals around Canada developed visiting rules to prevent the spread of coronavirus and save masks, gowns, and...

Development of a Point of Care System for Automated Coma Prognosis

2018/19-2020/21 • $283,383 • PI,CO,Other
The Problem: Coma is a state of unconsciousness with a variety of causes. Traditional tests for coma outcome prediction are mainly based on a set of clinical observations (e.g., pupillary constriction). Recently however, event-related potentials (ERPs; which are transient electroencephalogram...

Establishing A Research Platform for Investigating and Optimizing PPE Filtration/Barrier Efficiencies Against Aerosolized Bacteria and Viruses in Clinical Healthcare Settings

2020/21 • $278,850 • PI,CO,Other
The state of emergency brought about by the pandemic has mercilessly exposed the shortfalls of our healthcare system, one of the most pressing being the severe shortage of personal protective equipment (PPE). To meet an urgent need for PPE, the government has taken several measures, such as...

Creating a Living Knowledge Translation Agenda to Improve the Delivery of Evidence-based Care in Adult Critical Care Medicine

2019/20-2020/21 • $276,344 • PI,CO
Healthcare systems need to more consistently incorporate findings from research into patient care. With the amount of research in the current medical literature, and limited resources available to apply this research, some research findings should be given higher priority over others. This is...

Epigenetic PowerBlade - DNA Precision Marks for Critical Illness

2020/21 • $161,222 • PI,CO,Other
Sepsis, whole body inflammation and organ failure triggered by an overwhelming and unbalanced response to infection, incurs enormous human and health care costs. Globally, over 30 million people are affected each year, at least a quarter of whom will die. The sequelae include physical, mental,...

Partnering with patients at the earliest stages of the research continuum: building a framework to involve patients in preclinical laboratory work

2019/20-2020/21 • $110,430 • PI,CO,Other
Patient engagement can have many benefits, such as making sure that research results are useful to patients. While this practice is becoming more common in clinical (human) research, it is less often used in "preclinical research" (animal/cell laboratory research). Our patient partner recently...

Therapeutic Plasma Exchange in Septic Shock: A Pilot Study

2020/21 • $100,000 • PI,CO
Septic shock, a life-threatening infection, is among the most common reasons for admission to intensive care units in Canada and is a leading cause of death. Septic shock leads to uncontrolled inflammation and blood clotting abnormalities that leads to death in up to up to 50% of patients. Apart...

Patient and Public Involvement in Preclinical Laboratory Research: A Scoping Review

2020/21 • $84,478 • PI,CO
Patient engagement in research is a movement which has been gaining endorsement from funding organizations, patient advocacy groups and researchers. Our patient partner (KH) who is working with a team of researchers studying sepsis (organ dysfunction from severe infection) brought to our...

Sex differences in preclinical models of sepsis: a systematic review

2020/21 • $56,250 • PI,CO
Many differences exist between men and women when it comes to how diseases affect the body, and how effective treatments for those disease are. Despite this, medical research has demonstrated a lack of gender diversity over the years, even more so in the preclinical animal research setting....

Canadian Traumatic brain injury Research Consortium (CTRC)

2015/16-2019/20 • $1,824,513 • PI,CO,Other
Traumatic brain injury (TBI) is the most common cause of death in the first half of life and the most frequent cause of long term handicaps for Canadians of all ages. TBI can be quite variable. Individuals who experience the mild form, called concussion, can appear normal on the outside but be...

Heparin anticoagulation to improve outcomes in septic shock: The HALO International Phase II Trial

2017/18-2019/20 • $631,125 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The most common cause of death in patients admitted with life-threatening infections is multi-organ failure that is mediated...

Improving Transitions in Care from ICU: Evaluation of an Electronic Communication Tool

2019/20 • $198,535 • PI,CO,Other
Patients in the intensive care unit (ICU) are very sick. When a patient leaves the ICU it is important that doctors and other healthcare providers have an effective way to communicate between themselves to share important information, like new medical problems or new medications. Often, the...

Canadian Sepsis Research Network: Improving CareBefore, During and After Sepsis

2019/20 • $24,970 • PI,CO,Other
Sepsis, the life-threatening response to infection, costs the Canadians more than $1.5 billon each year, leads to more than 1 in 18 deaths each year, and leaves many survivors with significant disability. In 2016 the World Health Organization (WHO) declared sepsis a global emergency. To meet the...

National Preclinical Sepsis Platform: Developing a framework for accelerating innovation in Canadian sepsis research

2019/20 • $9,995 • PI,CO
Sepsis is the body's life-threatening response to an infection. It is estimated that sepsis affects approximately 40,000 Canadians each year with over a billion dollars in annual health care costs. Research in scientific laboratories (preclinical research) has been very helpful in describing how...

Establishing Stakeholder Priorities for the Development and Implementation of Strategies to Support Gender Equity in Critical Care Medicine

2019/20 • $9,970 • PI,CO,Other
Over the past fifty years, more and more women have entered into the medical field. However, gender equity which is defined as the "fairness of treatment for women and men, according to their respective needs" has not been met in medicine. Less women than men are in positions of leadership or...

CYCLE Pilot: A multi-centre pilot randomized clinical trial of early in-bed leg cycling versus routine physiotherapy in mechanically ventilated patients

2015/16-2018/19 • $332,954 • PI,CO,Other
Background: Patients from the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. ICU survivors are typically very weak and disabled. Over half of these patients have severe leg weakness impairing their quality of life for up to 5 years after ICU discharge....

Point of Care Device for Rapid Quantification of Cell-Free DNA with Application in Severe Sepsis

2016/17-2018/19 • $240,400 • PI,CO,Other
Sepsis, the whole body response to infection, is associated with a high risk of intensive care unit admission, organ damage and death. Our clinical work has demonstrated that free DNA (cfDNA) released from cells into the bloodstream is a very strong predictor of ICU death. The current technology...

Noninvasive Functional Biomarker for Early Detection and Continuous Monitoring of Microvascular Dysfunction

2015/16-2017/18 • $319,446 • PI,CO,Other
Some people with a bacterial infection must be admitted to a hospital Critical Care Unit (CCU) because the infection caused an excessive inflammatory response, which resulted in organ failure. Doctors define this as "sepsis". There is no cure other than administration of antibiotics and...

Cellular Immunotherapy for Septic Shock (CISS): A Phase II Trial

2017/18 • $100,000 • PI,CO
Severe infection with shock (septic shock) in the intensive care unit (ICU) is common accounting for approximately 20% of admissions, of which 30-40% will die. Septic shock is associated with an immensely uncontrolled inflammatory response from the body that is initiated by the infectious...

CYCLE Vanguard: The Catalyst to an International Randomized Comparative Effectiveness Trial of Early in-Bed Cycling with Mechanically Ventilated Patients

2016/17 • $100,000 • PI,CO,Other
Background: Critically ill patients in the intensive care unit (ICU) are the sickest patients in hospital, and need advanced life-support. ICU survivors are typically very weak and disabled. Over half of them have severe leg weakness impairing their quality of life for up to 5 years after ICU...

Studies of plasma DNA in sepsis

2010/11-2015/16 • $794,086 • PI,CO
Severe sepsis (ie. life-threatening infections) is triggered by harmful microorganisms or their toxins in the blood or tissues. These harmful agents damage the lining of blood vessels which can lead to inflammation, blood clot formation, and vessel obstruction. In Canada, there are approximately...

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients: A Pragmatic Cluster Cross Over Pilot Trial

2015/16 • $99,504 • PI,CO,Other
Salt fluids are used extensively for acutely ill patients who are admitted to hospital. Two salt fluids commonly used are Normal Saline and Ringer's Lactate. Both are used to rehydrate patients, restore fluid volume and help stabilize blood pressure and failing organs. Both salt fluids have been...

Optimal VAsopressor TItratiON (OVATION) Pilot Randomized controlled Trial

2012/13-2014/15 • $379,077 • PI,CO
Patients who are admitted to intensive care units commonly suffer from illnesses that cause life-threatening low blood pressure. In this context, intensivists (physicians who care for patients in intensive care units) administer potent medications that increase blood pressure. Unfortunately,...

Heparin AnticoaguLation to improve Outcomes in septic shock: The HALO pilot

2012/13-2014/15 • $288,152 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The most common cause of death in patients admitted with life-threatening infections is multi-organ failure that is mediated...

Infection: What is it? How to find it. How to beat it!

2013/14 • $3,000 • PI,CO,Other
Infection is a problem that touches us all. Whether missing school or work due to the common cold, or suffering from more serious forms of infection such as sepsis, we all know someone whose life has been impacted by infection. In recognition of the human and economic burden of infection,...

A pilot randomized controlled trial to evaluate the efficacy of unfractionated Heparin in septic shock

2011/12-2012/13 • $50,000 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The cause of death in patients with life-threatening infections is often multi-organ failure that is mediated by severe...

Brevets

OUTIL D'EVALUATION DE RISQUE POUR PATIENTS ATTEINTS D'UN SEPSIS

The present invention provides a prognostic and mortality risk assessment method for patients with sepsis. The method involves measuring a combination of cell-free DNA (cfDNA), protein C, lactate, platelet count, creatinine level, and Glasgow Coma Score (GCS) and analyzing the measured values using a complementary log-log model to determine the daily and 28-day (or other fixed term) probabilities of dying for septic patients and a binomial Iogit model to distinguish septic patients from...
Applications connexes: WO2018CA50833, CA20183069196