Peter M. Dodek

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Projets de recherche récents

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial

2016/17-2018/19 • $1,166,819 • PI,CO
Probiotics are commercially available live bacteria thought to have health benefits when ingested. Studies have shown that probiotics may prevent 25% of all pneumonias when patients are on a breathing machine, 18% of all other infections, and 65% of serious bowel infections. However, previous...

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

2015/16-2018/19 • $1,106,933 • PI,CO
Acute kidney injury (AKI) represents a sudden decline in kidney function and is associated with a high risk of death. When AKI is severe, some patients require the initiation of kidney replacement therapy in the form of dialysis. Dialysis replaces the kidneys' usual functions by the removal of...

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial

2016/17-2018/19 • $1,105,849 • PI,CO
Bloodstream infections are a common and serious problem, affecting 15% of critically ill patients, increasing length of hospital stay by 2-3 weeks, adding $25,000-40,000 in excess hospital costs, and tripling the risk of death. At the same time, antibiotic overuse is also a common and serious...

REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU

2017/18-2018/19 • $887,256 • PI,CO
Patients who are critically ill in the Intensive Care Unit, especially those who need breathing machines, can develop ulcerations in the stomach that bleed. To prevent bleeding, most critically ill patients around the world receive a daily drug called pantoprazole that suppresses acid...

Integrating a quality of life assessment and practice support system in homecare services for older adults with life-limiting illness and their families

2015/16-2018/19 • $656,089 • PI,CO,Other
Older adults who have advancing life-limiting illnesses and who are receiving health care at home often have complex problems that affect both their ability to function and their overall quality of life (QOL). Progress has been made in the managing some aspects of chronic illness, including...

CYCLE: An international, multi-centre, randomized clinical trial of early in-bed cycling for mechanically ventilated patients

2018/19 • $412,622 • PI,CO
Background: Critically ill patients in the intensive care unit (ICU) are the sickest patients in hospital, and need advanced life support. People who survive their critical illness are typically very weak and disabled. Over half of them have severe leg weakness impairing their quality of life...

The Frequency of Screening and SBT Technique Trial: The FAST Trial (North American Weaning Collaborative)

2018/19 • $263,160 • PI,CO
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing. When patients start to get better, they gradually do more of the breathing and the machine does less-this is called weaning. Although ventilator use saves lives, the...

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

2015/16-2018/19 • $220,995 • PI,CO
Acute kidney injury (AKI) represents a sudden decline in kidney function and is associated with a high risk of death. When AKI is severe, some patients require the initiation of kidney replacement therapy in the form of dialysis. Dialysis replaces the kidneys' usual functions by the removal of...

De-Adopting Low-Value Practices in Critical Care Medicine

2017/18-2018/19 • $214,200 • PI,CO
Frequent failure to implement best evidence into patient care practices is arguably the largest deficiency in modern healthcare, resulting in suboptimal patient care, preventable medical errors, and increased morbidity and mortality. There is a growing body of literature which suggests that the...

Moving from Moral Distress to Moral Action in Intensive Care Units

2016/17-2018/19 • $200,000 • PI,CO
A growing body of empirical research points to high levels of frustration, anxiety, fear, anger, sorrow, self-doubt, and guilt that health care providers experience when they feel powerless to practice according to their ethical standards. These emotions reflect moral distress which develops...

Family-administered delirium detection in the critically ill

2018/19 • $142,800 • PI,CO
Delirium is a brain condition in which patients become very confused and lose their ability to focus attention. Over half of the patients in intensive care units (ICUs) suffer from delirium during their ICU stay. Being older makes a patient more likely to develop delirium in the ICU. Research...

Frequency of Screening and SBT Technique Trial (the FAST Trial): A Factorial Design RCT

2017/18 • $100,000 • PI,CO
Background: The sickest patients who are admitted to an intensive care unit (ICU) often require assistance with their breathing. When patients start to get better, they gradually do more of the breathing and the machine does less-this is called weaning. Although ventilator use saves lives, the...

Canadian Critical Care Knowledge Translation Nework

2012/13-2015/16 • $599,611 • PI,CO,Other
The care of critically ill patients is a core function of hospitals. Critically ill patients are typically treated in Intensive Care Units (ICUs) and have high rates of mortality and prolonged disability. In addition, ICU care is a limited and expensive resource. The implementation of research...

Frequency of Screening and SBT Technique Trial: The FAST Trial

2014/15-2015/16 • $156,771 • PI,CO
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient. About 40% of the time spent on ventilators is dedicated to weaning. Limiting the time...

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial

2015/16 • $100,000 • PI,CO
Bloodstream infections are a common and serious problem, affecting 15% of critically ill patients, increasing length of hospital stay by 2-3 weeks, adding $25,000-40,000 in excess hospital costs, and tripling the risk of death. At the same time, antibiotic overuse is also a common and serious...

A National Strategy on Quality of Care Research and Evaluation - With the Patient for the Patient

2015/16 • $25,000 • PI,CO
Intensive care requires multidisciplinary teams that diagnose and provide care of patients with life-threatening conditions requiring sophisticated organ support and monitoring such as ventilator support, blood transfusions or dialysis when kidneys fail. Patients needing critical care range from...

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

2014/15 • $100,000 • PI,CO
Acute kidney injury (AKI) represents a sudden decline in kidney function and is associated with a high risk of death. When AKI is severe, some patients require the initiation of kidney replacement therapy in the form of dialysis. Dialysis replaces the kidneys' usual functions by the removal of...

Practice Pattern Variation in Discontinuing Mechanical Ventilation in Critically Ill Adults: An International Study.

2011/12-2014/15 • $85,000 • PI,CO
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the total time spent on ventilators is dedicated to weaning. The...

Structuring Patient-Oriented Research: Developing a National Agenda in Patient Care Research and Evaluation.

2014/15 • $25,000 • PI,CO
Critical care is essential to the Canadian healthcare system but it is very resource intensive. Its enormous human and financial cost underscores the pressing need for high quality evidence on effectiveness, an important aspect of quality care encompassing efficacy and cost. In Canada, up to 25...

Advance Care Planning Evaluation in Hospitalized Elderly Patients: A multicenter, prospective study. The ACCEPT Study

2011/12-2013/14 • $433,418 • PI,CO,Other
Our health care system is under siege- an aging population, patients living longer with chronic illness, and an increasing demand for services at end of life contribute to escalating costs. In a recent national survey, more than 80% of Canadians were concerned the quality of health care in...

CIHR Planning Grant for Traumatic Brain Injury Research

2013/14 • $24,856 • PI,CO,Other
The burden of traumatic brain injury (TBI) in Canada is significant. Death from TBI accounts for 20% of all trauma fatalities. In 2003 to 2004, there were 16,811 admissions for TBI with 1,368 deaths. Death can occur immediately at the scene, within a few hours, or later due to complications....

Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care for Octogenarians: The REALISTIC 80

2010/11-2011/12 • $497,339 • PI,CO
Every day in hospitals across Canada, frail elderly patients at or near the end of life are faced with decisions related to the use of life support machines. In a recent survey carried out at several large teaching hospitals across the country, seriously ill patients rated "not being prolonged...

The Impact of a Resident Work Schedule Change on Patient Safety

2010/11-2011/12 • $340,417 • PI,CO,Other
After graduation from medical school, physician education continues in a residency program in the individual's chosen area of specialty (e.g., Surgery, Internal Medicine). Residency programs have grueling schedules with frequent on-call shifts. These shifts are at least 24 hours in length,...

The Relationship between Moral Distress in Healthcare Workers and Patient Safety in ICUs

2010/11-2011/12 • $199,984 • PI,CO,Other
Patient safety depends on a culture of safety and a systematic approach to care. The effect of human factors on patient safety in Intensive Care Units (ICUs) has received little attention. One potentially important component of human factors is moral distress experienced by health care...

The efficacy, cost-effectiveness and ecological impact of Selective Decontamination of the Digestive tract in critically ill patients treated in the Intensive Care Unit (The SuDDICU study) PHASE 2- An exploratory study of the perceived risks, benefits and barriers to the use of SDD in Canadian critical care units

2010/11-2011/12 • $198,322 • PI,CO
Infections acquired in hospital are a major cause of illness and death for patients and markedly increase health care costs. Critically ill patients are particularly susceptible to these infections and do very poorly if they acquire them. Simple interventions such as hand hygiene and improved...

Clinical Practice Guidelines for Ventilator Associated Pneumonia

2011/12 • $99,079 • PI,CO,Other
Pneumonia that occurs in patients receiving mechanical ventilation is termed Ventilator associated pneumonia (VAP). VAP is a common cause of morbidity and mortality in critically ill patients. It is associated with increases in intensive care unit stay, hospital stay and prolongation of duration...

EPITEC - Epidemiology of ThromboEmbolism in Critical care

2010/11-2011/12 • $60,000 • PI,CO
Blood clots that develop in veins of the legs or arms because of serious illness and inactivity may break off and travel to arteries in the lungs. Lung clots are extremely dangerous and are a leading cause of hospital death worldwide. The most seriously ill hospitalized patients on life support...

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