Simon J. Graham

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Projets de recherche récents

Development of the next generation ultrasound therapy

2017/18-2020/21 • $1,739,517 • PI,Other
Focused ultrasound is a non-invasive means to deliver energy into targeted tissue within the body. At high power levels, focused ultrasound, when combined with quantitative MR imaging for on-line guidance, can be used to produce well-defined regions of thermal coagulation. The first generation...

Brain imaging of sport concussion: mapping recovery relative to pre-injury structure and function

2018/19-2020/21 • $503,585 • PI,CO
Concussions are a growing health concern, with over 4 million occurring annually in sport and recreation in North America. These injuries are associated with impairments in thinking (confusion, feeling "slow"), emotion (anger, depression) and physical function (dizziness, nausea). Currently,...

Brain imaging biomarkers of recovery from sport concussion

2016/17-2020/21 • $364,761 • PI,CO
Concussions are a growing health concern, with over 4 million occurring annually in sport and recreation in North America. These injuries are associated with a variety of impairments in thinking (confusion, feeling "slow"), emotion (anger, depression) and physical function (dizziness, nausea)....

Parallel Radiofrequency Transmission MRI Applied to Deep Brain Stimulation

2019/20-2020/21 • $354,153 • PI,CO
Deep brain stimulation (DBS) is increasingly used to treat the symptoms of many brain conditions. Neurosurgery is performed to implant metal electrodes into targets deep within the brain; then, a small device is also implanted underneath the skin, in the upper chest, to send electrical signals...

Identifying vascular targets to treat cerebral small vessel disease

2019/20-2020/21 • $257,919 • PI,CO
The arteries that enter the brain are approximately one centimeter wide. These arteries branch into smaller vessels, called arterioles. The branching is repeated until the vessels are many times smaller in width. It is at this small level that vessels supply brain tissue with the oxygen and...

Optimising fMRI Detection of Longitudinal Changes in Age-Related Brain Disorders

2014/15-2019/20 • $586,324 • PI,CO
Functional magnetic resonance imaging (fMRI) is becoming the brain imaging methodology of choice for studying normal aging and age-related diseases of the brain. But these are complicated studies and in order to optimise use of fMRI there are still many issues we do not understand. Our goal is...

CIHR Team in Traumatic Brain Injury and Violence

2010/11-2014/15 • $1,887,348 • PI,CO
Traumatic Brain Injury (TBI) accounts for 50% or more of all trauma deaths, and an estimated 2% of the population live with lifelong disabilities resulting from TBI. There appears to be a direct link between TBI and violence, which itself is a major issue for Canadians. The goal of the research...

Diffuse brain damage effects on distributed systems: multimodal brain imaging and rehabilitation

2010/11-2014/15 • $768,393 • PI,CO
Diffuse brain damage affects communication in distributed systems that support complex information processing, yet few neuropsychological or brain imaging studies directly address the effects of diffuse injury or apply interventions targeting neuropsychological disabilities. The objectives of...

Neurocognitive Correlates of Hypertension and Type 2 Diabetes in Older Adults

2010/11-2014/15 • $498,524 • PI,CO
Numerous factors contribute to the fact that some adults retain their cognitive function with aging while others show increasing degrees of losses. Both hypertension and type 2 diabetes are among these risk factors. This proposal will explore changes in brain blood flow and brain activity in...

Validation of non-invasive rapid eye movements measurement as screening tool for mild traumatic brain injury

2012/13-2014/15 • $250,140 • PI,CO
Mild traumatic brain injury (mTBI; including concussion) is a common problem. Properly identifying mTBI is important in order to prevent premature return to activities and to start timely and appropriate treatments. Presently there are no validated, portable tools available to objectively...

Driving and the aging brain: an immersive fMRI study

2014/15 • $144,553 • PI,CO
Older drivers are the fastest growing segment of the driving population. Driving is an essential daily activity for many people within the aging population. It offers individuals the ability to travel, a sense of independence; for some people, it is a source of livelihood. However, the crash...

Tablet Technology for Assessing Dementia

2011/12 • $116,402 • PI,CO
We have recently developed custom tablet technology for use in magnetic resonance imaging (MRI) systems to record brain activity. There is strong interest in commercializing this technology, initially so that neuroscientists can use the tablet in completely new experiments to unravel how the...

Behavioural and neural correlates of autobiographical memory in ECT and depression

2010/11-2011/12 • $109,774 • PI,CO
Electroconvulsive therapy (ECT) is given as a treatment in cases of severe, treatment-resistant depression. Although it is highly successful in relieving the depressive symptoms, one frequent side effect is impaired memory for personal events in general, and recent events in particular. One...

Towards clinical fMRI: Characterizing a rapid, multi-task, fMRI battery as a function of age

2010/11 • $72,804 • PI,CO
Functional magnetic resonance imaging (fMRI) is rapidly becoming the neuroimaging methodology of choice for studying normal aging and age-related diseases of the brain, such as stroke. However, there are currently few links between most neuroscience-oriented fMRI studies, and clinical testing in...

Characterizing fMRI and MEG signals in the somatosensory cortex

2010/11 • $29,068 • PI,CO
This research primarily focuses on a technique known as functional magnetic resonance imaging (fMRI), which yields approximate pictures of how neurons in the brain become more active in response to a sensory stimulus. Functional MRI is "indirect" because small changes in blood flow, blood...