Gilles J. Lavigne

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Projets de recherche récents

CRISM-Quebec-Maritimes: Research on interventions in drug misuse

2014/15-2020/21 • $2,374,845 • PI,CO,Other
Substance misuse remains a significant global public health problem which carries a heavy burden for abusers and their families alike. This disorder is indeed associated with suffering and severe health problems in patients, distress among family members, as well as tremendous costs to society....

Mobilizing the healthcare community towards an integrated approach to improving outcomes of patients with sleep disorders - Canadian Sleep and Circadian Network (CSCN)

2015/16-2020/21 • $2,041,427 • PI,CO
Obstructive sleep apnea (OSA) affects over 1 million Canadians. OSA leads to significant cardiovascular and metabolic health problems and patients with untreated OSA are at higher risk of stroke and Alzheimer's disease. The vision of the Canadian Sleep and Circadian Network (CSCN) is to mobilize...

Douleur, sommeil et traumatologie

2014/15-2020/21 • $1,400,000 • PI
Our 20142021 research program aims to further understand the causes of developing chronic pain (20% of the Canadian population) and sleep disorders. Our projects are in continuity with the first CRC funding period (20072014). We are investigating new ways to prevent the consequences of pain on...

Directed Grant: Oral Health Network

2017/18-2020/21 • $655,231 • PI,CO
Oral health research contributes significantly to improvement of oral health status of Canadians. Improvements in oral health research, in turn, can largely benefit from increased networking of those involved, from patients to oral care providers, from basic science researchers to manufacturers...

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study)

2018/19-2020/21 • $606,804 • PI,CO
Opioids (morphine and morphine-like substances) are often prescribed to patients to manage pain after an emergency department visit. In the past 20 years, opioid prescriptions have risen sharply, accompanied by a significant rise in opioid misuse (e.g., recreational or non-medical use,...

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury.

2019/20-2020/21 • $406,269 • PI
Recreational cannabis is legal in Canada since October 2018. Based on Colorado's experience, the first U.S. state to have legalized recreational cannabis in 2014, effects on Canadians' health are to be expected including: 1) increased recreational cannabis use; and 2) increased risk of traumatic...

Adherence and preference of Continuous Positive Airway Pressure versus Mandibular Advancement Splints in Obstructive Sleep Apnea patients: a randomized trial.

2014/15-2017/18 • $425,794 • PI,CO
Obstructive sleep apnea (OSA) is a major health problem affecting over 1,000,000 Canadians. It is the cause of significant healthcare costs with increased morbidity and mortality. The two most common and effective therapies used to treat OSA are: (1) Continuous or Automatic Positive Airway...

The Effect of Nocturnal Wear of Dentures on Sleep and Oral Health-Related Quality of Life: A Randomized Cross-Over Trial

2014/15-2016/17 • $269,847 • PI,CO,Other
Tooth loss and sleep problems are common conditions in elders. Tooth loss can influence sleep quality by changing the shape of the lower face and upper airway. While some studies suggest that sleeping without dentures can worsen sleep quality in toothless elders, others suggest the opposite....

Network for Canadian Oral Health Research

2012/13-2015/16 • $598,781 • PI,CO
The oral health of Canadians has improved dramatically over the past 30 years; children are much less likely to have tooth decay than in the past and older Canadians are keeping more of their natural teeth than their parents and grandparents did. This is good news - good oral health is essential...

Pathophysiology and treatment of restless legs syndrome

2010/11-2014/15 • $402,028 • PI,CO
Sleep is a universal biological experience and is an integral part of our health and life. Most people have learned from their own experience that sleep is essential to health, and the body restoration provided by sleep promotes wakefulness and a sense of well-being. However, sleep disturbance...

Troubles du sommeil, changements neuro-anatomiques et perception de douleur un an après un traumatisme craniocérébral (TCC) modéré/sévère.

2013/14-2014/15 • $110,000 • Scholarship/Fellowship,Other
Selon des resultats probants, la qualite du sommeil des patients TCC dans les mois suivant leur traumatisme pourrait amener des changements dans des regions du cerveau associees a la perception de la douleur et les predisposer au developpement du syndrome de douleur chronique. Cette etude vise...

Canada Research Chair on "Pain, Sleep & Trauma"

2010/11-2013/14 • $800,000 • PI
Our research program, for the next 7 years, is directed/focused toward the understanding of the relationship between pain (11-29% of population) and sleep disorders such as sleep bruxism (tooth grinding; 8% of population), sleep apnea (cessation of breathing; 2-4 % of population) and periodic...

The Effect of Nocturnal Wear of Dentures on Sleep and Oral Health-Related Quality of Life: A Randomized Cross-Over Trial

2013/14 • $100,000 • PI,CO,Other
Tooth loss and sleep problems are common conditions in elders. Tooth loss can influence sleep quality by changing the shape of the lower face and upper airway. While some studies suggest that sleeping without dentures can worsen sleep quality in toothless elders, others suggest the opposite....

Prevention of Opioid Analgesic Misuse in Canada: pragmatic and innovative strategies?

2013/14 • $50,000 • PI,Other
Pain that persists for months is categorized as chronic. Chronic pain is reported by 20% of the Canadian population and has major societal and economical impacts. Misuse of strong pain medication (opioid narcotics such as morphine, oxycodone) is sometimes necessary. Risk of opioid misuse (taking...

Genetic risk factors identification in Mild Traumatic Brain Injury patients who develop chronic pain and poor sleep: A prospective study

2010/11-2012/13 • $85,000 • Scholarship/Fellowship,Other
Mild Traumatic Brain Injuries (MTBI) is estimated to occur to 600 individuals in a 100 000 population. A large percentage of patients post-trauma will develop chronic sequelea. The most common problems include sleep problem, chronic pain, headaches, memory loss and difficulties to concentrate....

Neurophysiology of sleep bruxism: Interactions with respiration, orofacial pain & headache

2010/11-2011/12 • $203,656 • PI,CO
Sleep bruxism (SB) is a sleep movement disorder characterized by tooth grinding that causes patients to experience orofacial and neck pain with headaches as well as disrupting the sleep of bedroom partners. Fourteen percent of children grind their teeth and 8% of adults are aware of frequent...

Diagnostic, physiopathologie et traitement des troubles du sommeil

2010/11 • $126,633 • PI,CO
Plusieurs etudes epidemiologiques ont montre la prevalence elevee des troubles du sommeil dans la population generale. Cette conclusion ressort clairement d¿un rapport de la National Sleep Foundation qui montre que 7 americains sur 10 eprouvent des troubles frequents du sommeil dont la plupart...

CIHR training program in applied Oral Health Research

2010/11 • $70,985 • PI,CO
Millions of Canadians suffer from poor oral health. Their problems range from dental decay and gum disease to loss of all their teeth, serious malformations and cancer. These diseases cause pain, discomfort and reduce quality of life. They make it difficult to eat properly, which leads to...

Emerging Team on Mental Health and Neuroscience of Sleep Disorders

2010/11 • $10,000 • PI,CO
The proposed program will unite experts from two renowned sleep centres (at Universite Laval and Universite de Montreal) to study of the causes, risk factors, genetics and treatment of insomnia and other sleep disorders in adults and in children. The program also proposes to develop high-quality...

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