Ruth Ann Marrie

Contact via University of Manitoba

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Projets de recherche récents

Defining the Longitudinal Course, Outcomes, and Treatment Needs of Vulnerable Canadians with Posttraumatic Stress Disorder.

2015/16-2020/21 • $1,695,396 • PI,Other
Context. Although stress is a recurring and omnipresent problem, there are major gaps in knowledge about the hallmark condition related to traumatic stress (i.e., posttraumatic stress disorder [PTSD]). Over 70% of Canadians are exposed to traumatic events (e.g., physical injury, assault) in...

Disease-modifying Drug Safety and Effectiveness in Multiple Sclerosis [DRUMS]

2018/19-2020/21 • $525,603 • PI,Other
The goal of our research is to determine how safe and effective the drugs used to treat multiple sclerosis (MS) are when used in the real world. Canada has some of the world's highest rates of MS. This chronic disease of the brain and spinal cord often affects young adults and there is no known...

Tumor necrosis factor inhibitors (TNFi) and Risk of Multiple Sclerosis

2019/20-2020/21 • $96,314 • PI,CO
Tumor necrosis factor inhibitors (TNFi) are a relatively new class of medications used by patients with a rheumatic disease (RD) and inflammatory bowel disease (IBD) with moderate to severe disease. Case reports and two epidemiologic studies have alluded to a potential risk of multiple sclerosis...

Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease

2014/15-2019/20 • $2,443,500 • PI,CO
This Team Grant will create a multi-disciplinary team with complementary expertise. Our team will focus on the problem of psychiatric comorbidity (such as depression and anxiety disorders) in persons with chronic immuno-inflammatory diseases including inflammatory bowel disease (IBD), multiple...

Medication adherence in multiple sclerosis: a model for other chronic diseases?

2016/17-2019/20 • $282,865 • PI,CO
Only one in every two people with a chronic illness takes their medication as it was intended. This is referred to as medication adherence. People with poor medication adherence often have more health problems. They are also more likely to be hospitalized and are more likely to die. Poor...

The Canadian Longitudinal Study on Aging as a vehicle for population neuroscience.

2019/20 • $54,500 • PI,CO
The Canadian Longitudinal Study on Aging (CLSA) is large scale prospective study of aging that has recruited over 51,000 participants who have now undergone two full assessments (baseline and first follow up). During the CLSA interviews and physical assessments, information is sought on the...

Graphical Models and Mendelian randomization to characterize and validate grip strength as well as other measures of frailty in cardiovascular disease

2018/19 • $70,000 • PI,CO
Evidence suggests that a strong or weak hand grip may help measure an individual's risk for developing a cardiovascular disease, regardless of their age or the country they live in. Grip strength can be measured easily in a physician office and may help identify individuals at high risk of...

Prescription Drug Safety and Effectiveness in Multiple Sclerosis [DRUMS]: a population-based, multi-province platform for comprehensive pharmacovigilance

2018/19 • $67,787 • PI,CO
Canada has one of the world's highest rates of multiple sclerosis (MS). MS is a chronic disease of the brain and spinal cord. MS often starts in young adulthood and there is no cure. The goal of our research is to find out how safe and effective the drugs used to treat MS are when used in the...

CIHR Team in The Epidemiology and Impact of Comorbidity on MS in Canada (ECoMS)

2010/11-2014/15 • $1,349,773 • PI,CO
This Team Grant in Comorbidity and Multiple Sclerosis (MS) represents a joint initiative of four academic centres in British Columbia, Alberta, Manitoba and Nova Scotia and will create a multi-disciplinary team with complementary expertise. The research program has three objectives. First, we...

The Children of Multiple Sclerosis: Impact of chronic disease in parents on early childhood development

2011/12-2014/15 • $293,288 • PI,CO
The early years play a crucial role that extend far beyond childhood. Research has shown that challenges facing adult society, including mental health, obesity, criminality competence in reading and writing have their roots in early childhood. Health Canada has stated that having a parent with a...

Critical Illness in Inflammatory Bowel Disease, Multiple Sclerosis and Rheumatoid Arthritis

2011/12-2013/14 • $183,622 • PI,CO
Chronic immune diseases, such as inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), affect more than 5% of Canadians. Critical illness requiring admission to an intensive care unit (ICU) is serious and costly. We do not know much about the...

Depression and Multiple Sclerosis: A Systematic Review

2013/14 • $100,000 • PI,CO,Other
Depression is common in multiple sclerosis (MS). Fully half of MS patients can expect to be depressed at some point in their lives. This compares with 10-15% in the general population, and 15-25% in other serious diseases such as heart disease and cancer. Although depression in MS has received a...