Jonathan Kimmelman

Contact via McGill University

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Projets de recherche récents

Canadian Autoimmunity Standardization Core (CAN-ASC)

2018/19-2020/21 • $831,290 • PI,CO
To stay healthy, we need to have an immune system that works properly: it needs to attack foreign cells, but leave our own cells alone. If our immune system attacks our cells, it causes an illness called an autoimmune disease. There are many types of autoimmune disease, including type 1...

Ethics, Efficiency and Patient Burden in Drug Development

2016/17-2020/21 • $366,960 • PI,CO
Most new drugs entered into clinical development never show adequate safety and efficacy. As a result, many patients are harmed, resources are wasted, and major medical advances are delayed. This grant will follow up on previous work suggesting that researchers can be very efficient at...

Regulatory, Policy and Ethical Implications of Clinical Trial Portfolios

2019/20-2020/21 • $221,532 • PI,CO
New drugs are often tested in many clinical trials- often involving several different diseases (we call this collection of clinical trials "trial portfolios"). This vigorous research activity can generate a wealth of information that can be used to inform policy decisions as well as patient...

Translation of Highly Promising Basic Science Research into Clinical Applications: A Systematic Review

2019/20-2020/21 • $128,783 • PI,CO
Drugs and other treatments are often shown to be very effective in animal studies performed in laboratories. However, these promising findings rarely translate to the human population. In 2003, a landmark review of laboratory studies demonstrated only 5% of highly promising animal experiments...

Vascular Network

2013/14-2018/19 • $4,450,000 • PI,CO,Other
Many of the most devastating diseases can be directly linked to a common cause: damage to the vascular system often caused by common risk factors. The vascular system includes not only the main arteries feeding the heart and brain, eyes, kidneys and all other organs of the body, but also the...

Interventions for the Opioid Crisis: A Systematic Review Examining Approaches in the Canadian Context and Vulnerable Sub-Populations

2018/19 • $99,997 • PI,CO,Other
Canada is experiencing a major opioid crisis. In 2017, more than 3,900 Canadians died of apparent opioid-related overdoses. Although several interventions have been proposed, Canada lacks a comprehensive strategy to adequately manage this epidemic. Thus, it is imperative to evaluate current...

Legalization of Recreational Cannabis Use in Canada: A Knowledge Synthesis

2017/18 • $99,998 • PI,CO,Other
We will conduct scoping reviews of the literature concerning the legalization of recreational cannabis use in Canada and its potential impact on trends in use and vulnerable sub-populations. We will also describe and compare international approaches to recreational cannabis regulation. Our...

Canadian Autoimmunity Standardization Core (CAN-ASC)

2017/18 • $25,000 • PI,CO
A functional immune system is essential for health. In a process called immune tolerance, it fends off dangerous foreign substances but leaves the body's own tissues untouched. Failure of immune tolerance causes chronic autoimmune diseases in which the immune system sees the body's own cells as...

Can Researchers Predict Trial Outcomes and Feasibility? An Empirical Investigation

2013/14-2016/17 • $280,007 • PI,CO
Clinical trials involve exposing patients to drugs that have uncertain therapeutic value. They are also very expensive and complicated to run. Protecting patients in trials, and using limited research resources wisely, requires that researchers have realistic expectations about outcomes in their...

Signal, Safety, and Success: An Analysis of Risk, Benefit, and Translation after Detection of Clinical Activity in Drug Development

2011/12-2015/16 • $319,820 • PI,CO
The vast majority of new drugs entered into clinical development never show adequate safety and efficacy. As a result, many patients are harmed and resources spent in failed trials. This grant is aimed at discovering whether there are ways to better protect patients, learn from failure, and save...

How Suggestibility May Influence Placebo Response: Insights From a Novel Experimental Design

2010/11-2014/15 • $410,000 • PI,CO
While placebos are known to exert powerful therapeutic effects on some patients, we still have a poor understanding of the mechanisms which underlie them, as well as the characteristics of placebo responders. A leading explanation for placebo effects emphasizes the role played by patients'...

Animals, Humans, and the Continuity of Evidence: A Study of Clinical Translation

2011/12-2013/14 • $273,952 • PI,CO
In the last two decades, researchers have made enormous progress in understanding the causes of human disease. Yet many important discoveries have not yet had an impact on the practice of medicine. This grant aims to understand some of the reasons why therapies that show promise in animals never...

Ethics in Translational Research: Navigating the Interface between the Bench and Clinic

2010/11-2013/14 • $195,000 • PI
This research proposes to extend my previous work on gene therapy by examining the ethics of testing drugs in human beings for the first time-- a process called "translational clinical research." I propose to study the ethics of three aspects of this research: when to make the "leap" from animal...

The Clinical, Regulatory, and Ethical Implications of Electronic Cigarettes: A Knowledge Synthesis Grant

2013/14 • $100,000 • PI,CO,Other
IssueDespite the growing popularity of e-cigarettes, their use and regulation remain controversial. Sold directly to consumers, they are marketed as lower-cost, tobacco-free alternatives to cigarettes that can be smoked anywhere. They look and feel like cigarettes, some containing nicotine, and...

Justifying Translational Clinical Trials: An Ethical Analysis of Risk, Design, and Prediction

2010/11-2011/12 • $158,495 • PI,CO
Patients who enroll in "translational clinical trials" are the first human beings to receive a drug after it has been tested in animals. Because these trials involve a high degree of uncertainty about risk and benefit, they present a number of unresolved ethical challenges. This grant proposes...

States of Mind: Emerging Issues in Neuroethics

2010/11 • $275,300 • PI,CO
In 2001, at the close of the decade designated by presidential proclamation as the ¿Decade of the Brain¿, William Safire coined the phrase ¿neuroethics¿ and, from the platform of his column in the New York Times, announced the need for such a discipline. The proposed States of Mind New Emerging...

Informing the decision to participate in a clinical trial: Can decision aids improve the quality of trial participation decisions?

2010/11 • $94,735 • PI,CO
Ever since the development of the Nuremberg Code in response to Nazi war crimes, informed consent has been a cornerstone of the ethical practice of healthcare research. Despite the fundamental importance of this principle, however, there is increasing evidence of a failure of current informed...