Charles H. Tator

Contact via University of Toronto

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Projets de recherche récents

Polymeric Biomaterials for Applications in Medicine

2015/16-2020/21 • $2,263,895 • PI,Other
Overarching Direction of Research ProgramTo design biomaterials solutions to unsolved problems in medicine. To influence cell fate through local and targeted delivery strategies and engineered three-dimensional (3D) hydrogel microenvironments. We will design novel injectable hydrogels for local...

Concussion & You: A peer-led approach to raising concussion awareness in Canadian high schools

2017/18-2020/21 • $616,182 • PI,CO
Concussion is a common injury amongst Canadian youth with high school students being the most at risk. Post-concussion symptoms can have a significant impact on youth participation in daily activities and overall health. To improve health outcomes of youth we must provide them with the tools and...

Modifying membrane structure to promote neuronal survival and regeneration

2013/14-2018/19 • $744,032 • PI,CO
Nerve cell injuries lead to the loss of functions, such as vision or the ability to move. To preserve or even restore these functions it is important to maintain nerve cells alive and allow them to function normally again. To function properly, nerve cells require to be connected with each...

Generating innovation through the use of common data: Improving the diagnosis and treatment of pediatric and adolescent mild traumatic brain injury in Canada.

2012/13-2017/18 • $766,895 • PI,CO,Other
The incidence of pediatric traumatic brain injury (TBI) in North America is alarmingly high; studies suggest that mild TBI (mTBI) make up 70-80% of all cases reported. Of particular concern is that not only do many post-concussive symptoms, which manifest as cognitive, physical and behavioural...

"NeuroCare" as Innovation in Intervention: A Neurophysiological Approach to Determine Readiness for Return to Activity

2012/13-2017/18 • $565,728 • PI,CO,Other
To date, there are major gaps in our knowledge about how to best manage the physical and cognitive demands associated with returning adolescents to activity following mild traumatic brain injury (mTBI). Returning to activities prior to the brain healing from its injury may result in delayed...

Canadian concussion research network and agenda planning meeting

2017/18 • $17,247 • PI,CO,Other
Concussions affect over 3 million people in North America annually yet remain under recognized and poorly understood. The Canadian government has mandated that the Ministers of Health and of Sport and Persons with Disabilities work together to support a national strategy to raise awareness about...

The Canadian Concussion Centre's Inaugural Symposium on Concussion in Women

2016/17 • $8,000 • PI,CO
Concussions, which are a common and potentially very serious brain injury, represent a major public health issue in Canada. While research has typically focused on the males, there is increasing recognition that the female population requires more focus. This is particularly important, as sex...

Local Delivery of Therapeutic Biomolecules to the Injured Spinal Cord

2012/13-2015/16 • $411,821 • PI,CO
Traumatic spinal cord injury is devastating. It comes without warning to our most physically active youth. There is no cure for spinal cord injury, and only limited surgical interventions are available. There are some biomolecules that have generated significant excitement in the community, but...

CIHR Team in Traumatic Brain Injury and Violence

2010/11-2014/15 • $1,887,348 • PI,CO
Traumatic Brain Injury (TBI) accounts for 50% or more of all trauma deaths, and an estimated 2% of the population live with lifelong disabilities resulting from TBI. There appears to be a direct link between TBI and violence, which itself is a major issue for Canadians. The goal of the research...

Bioengineered cell delivery system

2011/12-2013/14 • $344,130 • PI,CO
Traumatic spinal cord injury is often described in terms of the primary injury, which results from a mechanical insult such as a motor vehicle or sports-related accident, and the secondary injury, which results in a cascade of events, resulting in an inhibitory environment. The latter limits...

Minimally-invasive Drug Delivery Strategy for Acute Spinal Cord Injury Repair

2010/11-2012/13 • $322,527 • PI,CO
After traumatic spinal cord injury, the communication pathway between the brain and the rest of the body (the periphery) deteriorates, resulting in essentially lost function below the site of injury. To promote communication between the brain and the periphery after injury, we are developing a...

Improving spinal cord regeneration after injury by enhancing the survival of neural stem progenitor cells

2010/11 • $17,500 • Scholarship/Fellowship,Other
Spinal cord is the main pathway for transmission of information between the brain and the peripheral body. Damage to the spinal cord disrupts the link between the brain and the body, causing permanent disabilities, such as paralysis, loss of sensation and intractable pain. At present, there is...