Sheldon W. Tobe



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Projets de recherche récents

Using big data to conduct innovative cardiovascular clinical trials

2016/17-2020/21 • $3,078,221 • PI,CO,Other
Traditional randomized clinical trials (RCTs) have provided extremely valuable information on medical therapies (e.g., statins) and procedures that have changed the way cardiovascular diseases are treated. However, despite their contributions, traditional RCTs are costly, their findings may not...

Alcohol consumption and change in blood pressure: evidence synthesis of 24 hour trial data and modelling of intervention effects

2020/21 • $35,000 • PI,CO
Screening for hazardous and harmful drinking is rarely done in clinical practice. Health care providers face two major barriers when considering advice and treatment for patients with hypertension regarding their alcohol consumption: knowledge and motivation. First, clear guidance and...

Community Health Assessment Program in the Philippines (CHAPP)

2014/15-2019/20 • $1,466,575 • PI,CO
The research proposed will test whether the Community Health Assessment Program in the Philippines (CHAPP) will be effective in decreasing the number of people who have high risk of having the diabetes. The CHAPP is a community program which will be implemented by trained volunteers. In the...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Enhancement and Adaptation of Community-driven Innovations and Scale-up Toolkits

2016/17-2019/20 • $652,110 • PI,CO,Other
In Canada, there are significant disparities between the health status of Indigenous peoples and the general population with respect to diabetes. Community-driven innovations, activated by quality improvement processes, have the potential to reform local healthcare. The goal of the proposed...

Canadian Collaboration for Patients with Complexity: Innovation to promote optimal and appropriate care for all.

2019/20 • $10,000 • PI,CO
Nearly 10 million Canadians live with multiple chronic conditions like diabetes, heart disease, depression, arthritis or lung disease. These conditions can make daily life challenging, and having several conditions can increase the risk of poor health and low quality of life. Having chronic...

Vascular Network

2013/14-2018/19 • $4,450,000 • PI,CO,Other
Many of the most devastating diseases can be directly linked to a common cause: damage to the vascular system often caused by common risk factors. The vascular system includes not only the main arteries feeding the heart and brain, eyes, kidneys and all other organs of the body, but also the...

Canadian Atrial Fibrillation Stroke Prevention Intervention Network (CAF-SPIN)

2013/14-2018/19 • $4,450,000 • PI,CO
Atrial fibrillation is an irregular beating of the heart and is one of the most common causes of stroke in Canada. Fortunately, medical research, has produced several treatments, including blood thinners and blood pressure lowering drugs, which can reduce the risk of stroke by over 75%. However;...

Canadian Chronic disease Awareness and Management Program (C-CHAMP)

2013/14-2017/18 • $2,496,974 • PI,CO,Other
The most prevalent chronic health conditions are largely the product of interactions among a small set of well-established, modifiable causes, such as smoking, having a sedentary lifestyle, heavy drinking and high salt consumption. These chronic health conditions, notably obesity, diabetes and...

Starting on a healing path rooted in First Nation cultural and clinical approaches to Opioid Replacement Therapy: Mino-bimaadiziwin after Addiction

2017/18 • $150,000 • PI,CO,Other
With a population of approximately 4000 people, Wikwemikong Unceded Territory is one of the largest First Nations communities in Canada. While the community is thriving in many ways, there is also an increase in opioid addiction. The community has responded by developing cultural healing...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Community-driven Innovations and Strategic Scale-up Toolkits

2013/14-2016/17 • $2,500,000 • PI,CO,Other
In Canada, significant disparities between the health status of Indigenous peoples and the general population exist, particularly for chronic diseases such as diabetes. There is a pressing need to shift the present episodic care focus common to most First Nations communities, to one that...

DREAM-GLOBAL: Diagnosing hypeRtension - Engaging Action and Management in Getting LOwer Bp in Aboriginal and LMIC - A Research Proposal

2011/12-2016/17 • $1,804,101 • PI,CO,Other
Heart disease and stroke are the number one killers world-wide. When someone has hypertension, the constantly elevated blood pressure damages their blood vessels and the organs that they supply blood to. This causes stroke, heart attack, heart failure, kidney failure and dementia. Finding and...

Mino-bimaadiziwin: Enhancing Wellness in Anishinabek Communities in Northern Ontario through Indigenous Ways of Knowing

2016/17 • $149,945 • PI,CO,Other
This project is a collaboration between Anishinaabe communities and organizations in Northern Ontario and academic researchers with long-standing research relationships. Jointly we aim to do the following: 1) to study the Indigenous concept of wellness, called mino-bimaadiziwin from the...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Enhancement and Adaptation of Community-driven Innovations and Scale-up Toolkits

2016/17 • $5,744 • PI,CO,Other
Given the dramatic rise and impact of chronic disease and gaps in care in Indigenous communities, a shift from the existing episodic healthcare model common in Indigenous communities to one that integrates prevention and chronic disease management is needed. To assist with this transition, the...

Optimizing the Transfer and Uptake of Evidence-based and Culturally Appropriate Healthy Lifestyle Information in Aboriginal Communities

2015/16 • $11,500 • PI
Aboriginal peoples exhibit clear health disparities with alarming rates of cardiometabolic disease and related complications. We have worked extensively in Aboriginal communities designing culturally appropriate preventive strategies. Several barriers to the translation and uptake of health...

Aboriginal Research Gathering 2016

2015/16 • $11,000 • PI,CO
Ontario has the highest proportion of Aboriginal people in Canada and in Northern Ontario ~20% of the population is of Aboriginal descent. There is a great need for research that develops solutions to the continuing health disparities and inequitable access to culturally appropriate health and...

Heart outcomes prevention evaluation (HOPE-3) trial. A large simple randomized trial of combined cholesterol modification and blood pressure lowering in middle aged people at average risk

2010/11-2014/15 • $4,012,926 • PI,CO
Heart disease and stroke are major causes of death and disability worldwide and are largely preventable. Cholesterol and blood pressure are major cardiovascular risk factors. Previous studies have shown that certain drugs can effectively and safely lower cholesterol and blood pressure and...

Curcumin to prevent perioperative complications after elective abdominal aortic anuerysm repair

2011/12-2013/14 • $322,419 • PI,CO
An abdominal aortic aneurysm (AAA) is a ballooning of the abdominal aorta, the major blood vessel of the body. AAA occurs in up to 2% of adults. Surgeons will plan an AAA repair when the aneurysm grows bigger than 5.5cm, because the AAA might burst without repair. Over 47,000 AAA repairs are...

Establishing the Chair's Advisory Council (CAC) for the Inaugural Heart and Stroke Foundation(HSF)/Northern Ontario School of Medicine (NOSM) Aboriginal and Rural Health Research Chair

2013/14 • $25,000 • PI,CO,Other
Heart disease and stroke and cancer are the number one killers world-wide. Rates of cardiovascular diseases in Northern and Aboriginal communities exceed those of the rest of the country putting them at a greater risk of heart disease and stroke, compared to the general population. Cancer rates...

Strategic Planning to Support First Nations Communities Participating in the FORGE AHEAD Program

2013/14 • $24,997 • PI,CO,Other
The proposed planning activities, including a face-to-face meeting, will enhance existing partnerships as well as foster the development of new partnerships by bringing together members of a national steering committee that includes First Nations (FN) community representatives, academic...

First Nations Community-Based Chronic Disease System Improvment Strategy - Planning Grant

2011/12 • $24,999 • PI,CO
The purpose of this application is to request funding for a series of planning meetings that will be used to form a national, interdisciplinary research team with expertise in First Nations health and to develop a submission for the Team Grant in Community-Based Primary Healthcare. The...

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