TongJun Lin

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Projets de recherche récents

Mechanisms and regulation of Toll-like receptor signaling in Pseudomonas aeruginosa infection

2015/16-2019/20 • $138,456 • PI
Mechanism of Pseudomonas aeruginosa infection remains incompletely defined. We showed that Toll-like receptor (TLR) signaling pathways (the MyD88-IRAK pathway and the TRIF-IRF3/7 pathway) are activated by P. aeruginosa . Activation signals are subsequently inhibited by the negative signals that...

NSERC - SENTINEL - Bioactive Paper Strategic Network

2010/11-2015/16 • $7,594,000 • PI,CO
Bioactive paper that can detect and deactivate dangerous bacteria and viruses in food and water will deliver health benefits around the world. Bioactive Paper is a made-in-Canada concept articulated in the first phase (2005-2010) of the Sentinel Bioactive Paper Network, an NSERC strategic...

A role of TRPV6 calcium channel inhibition on cytokine and chemokine production by epithelial cells

2015/16 • $25,000 • PI
Peptides derived from soricidin (C-peptides, eg SOR-C13 and SOR-C27), the paralytic peptide in saliva of the Northern Short-tailed shrew (Blarina brevicauda) bind the calcium ion channel TRPV6 (Transient Receptor Potential Vanilloid family number 6). Binding of the C-peptides to TRPV6 inhibits...

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