Alexis F. Turgeon


Contact via Laval University


Principaux champs de recherche
Chercheur(e)s associé(e)s
Organisations associées

Projets de recherche récents

Unité SUPPORT du Québec : Un soutien pour la recherche axée sur le patient

2014/15-2020/21 • $23,587,002 • PI,CO,Other
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The Canadian Network of COVID-19 Clinical Trials Networks

2020/21 • $6,000,000 • PI,CO,Other
Nearly 350,000 Canadians have been diagnosed with COVID-19 infection. In Canada, the elderly have been particular vulnerable, with long-term care homes experiencing the greatest burdens of illness and mortality. Civil society and our usual social fabric have been torn, due to illness, loss,...

A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury: (The RE-ENERGIZE Study)

2015/16-2020/21 • $5,777,352 • PI,CO
Patients with severe burns need to recover in a hospital burn unit for a long time and are at high risk of developing infections and dying. Proper nutrition and certain nutrients may improve survival in these patients and shorten their stay in the burn unit. Glutamine is a building block of...

ANTI-THROMBOTIC THERAPY TO AMELIORATE COMPLICATIONS OF COVID-19 (ATTACC): A randomized, international, multi-centre, adaptive, controlled clinical trial

2020/21 • $3,573,336 • PI,CO
COVID-19 is associated with an unusually high risk of blood clots. Small studies have suggested that anticoagulant (blood thinning) medications that prevent blood clots from forming or travelling may improve the health and survival of hospitalized patients with COVID-19. The goal of this study...

HOST RESPONSE MEDIATORS IN CORONAVIRUS (COVID-19) INFECTION - IS THERE A PROTECTIVE EFFECT OF ARBs ON OUTCOMES OF CORONAVIRUS INFECTION? (ARBs CORONA II)

2020/21 • $3,456,541 • PI,CO
As the COVID-19 pandemic continues to spread globally, the World Health Organization (WHO) and others are actively conducting clinical trials for anti-virals to combat this disease. However, many of the severe complications of COVID-19 are caused by the host's response to viral infection. We...

A Randomized Open-Label Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness (CONCOR-1)

2020/21 • $2,972,273 • PI,CO
The COVID-19 pandemic has affected over 4 million people and caused over 300,000 deaths worldwide. There is no known treatment for COVID-19 and it can take many months before a vaccine becomes available. There is a fairly significant body of anecdotal evidence that suggests the plasma from...

Anticoagulation and Convalescent Plasma ICU Trials in REMAP-CAP

2020/21 • $2,176,566 • PI,CO,Other
Current recommendations for managing critically ill patients struggling with COVID-19 focus on supportive care and prevention of complications. As the development of vaccines and new drugs against SARS-CoV-2 virus will take several months to years, there is an urgent need to optimize the...

PROphylaxis for venous ThromboEmbolism in Severe Traumatic brain injury (PROTEST): a Double-blind Randomized Controlled Trial

2018/19-2020/21 • $1,938,143 • PI,CO
Severe traumatic brain injury is common, potentially lethal, and can result in severe and irreversible disability. It is also often associated with potentially life-threatening complications during the early period following the injury, when patients are critically ill and receiving life...

Optimal Practices in Critical Care Neurology and Trauma

2016/17-2020/21 • $1,887,301 • PI,Other
Worldwide, trauma represents an enormous burden with more than 1.4 million deaths in road traffic accidents alone. Most trauma deaths are associated with brain injuries that cause severe permanent impairments and generate significant costs associated with health care resource utilization....

A systematic and living evidence and guideline recommendation map on COVID-19

2020/21 • $1,456,275 • PI,CO,Other
Under the leadership of the World Health Organization (WHO) Collaborating Centre for Infectious Diseases, Research Methods and Recommendations and Cochrane Canada, this project will support Canada's contribution to the global response to the COVID-19 outbreak by bringing together world-class...

Computed tomography perfusion for neurological death determination: a prospective Canadian multicenter diagnostic test study

2016/17-2020/21 • $1,214,572 • PI,CO
For many patients with terminal heart, lung, liver and kidney disease, organ transplantation is the treatment of choice and most often their only hope for survival. Organs retrieved in patients after a process called the neurological death determination (NDD) represent the principal source of...

Aneurysmal Subarachnoid Hemorrhage - Red Blood Cell Transfusion and Outcome (SAHaRA):A Randomized Controlled Trial

2017/18-2020/21 • $1,136,604 • PI,CO
Aneurysmal subarachnoid hemorrhage (aSAH) is the result of a burst artery in the brain. It affects young people (40-60 years), nearly half of whom will die, and a third will have permanent disability. Managing patients with aSAH is challenging because the recovering brain is very sensitive and...

Transfusion in traumatic brain injury (TSiTBI Trial)

2016/17-2020/21 • $1,105,911 • PI,CO
The incidence of anemia (a decrease in the quantity or quality of red blood cells) is frequent among critically ill patients. Because red blood cells, through the molecules of hemoglobin, are oxygen carriers, a decrease in the availability of oxygen to the different organs is often to fear. In...

The NEUROlogically-impaired extubation Timing Trial (NEURO-ETT)

2015/16-2020/21 • $1,074,849 • PI,CO
Thousands of patients suffer severe brain injuries every year, from causes such as trauma, stroke, and infection. Many of them will have impaired consciousness and therefore be unable to keep food or mouth secretions from entering their lungs (called aspiration). To protect against aspiration,...

COVID-19 Evidence Network to support Decision-making (COVID-END)

2020/21 • $1,000,000 • PI,CO,Other
The science about how to prevent and manage COVID-19 and its spill-over effects on society is changing rapidly. Summaries of the best available science (which we call evidence syntheses) are the best place to turn when making decisions about public-health measures (e.g., wearing masks), clinical...

CODA-19: a Collaborative Data Analysis Platform to Improve Clinical Care in Patients with COVID-19

2020/21 • $937,950 • PI,CO
COVID-19 is a highly contagious acute respiratory illness that has undergone rapid global spread in the beginning of 2020. There is a pressing need to develop tools that can help physicians diagnose COVID-19 rapidly, determine if different disease presentations warrant different types of...

Automated Oxygen Titration, Monitoring and Weaning in patients with infectious pneumonia requiring oxygen - impact on the number of interventions for healthcare workers. An innovative device to manage patients with COVID-19 pneumonia. COVID study (Closed-Loop Oxygen to Verify that healthcare workers Interventions Decrease during pneumonia)

2020/21 • $829,476 • PI,CO,Other
Automated oxygen titration, weaning and monitoring (FreeO2 device) may be a solution to reduce the number of interventions of healthcare workers (which is directly related to the risk of transmission of COVID-19. There is a high risk of transmission of COVID-19 to healthcare workers. in a recent...

Canadian Program for Monitoring Overuse in Injury Care

2016/17-2020/21 • $806,718 • PI,Other
Injuries lead to 200,000 hospital stays, 60,000 disabilities, and 13,000 deaths per year in Canada with direct costs of $20b. Up to 30% of healthcare budgets are spent on potentially unnecessary tests and procedures (e.g. scans, blood transfusions, surgeries), exposing patients to avoidable...

Understanding decision making in organ donation: a national study

2018/19-2020/21 • $692,646 • PI,CO
Transplantation is the only hope for survival for many patients with terminal heart, lung, liver, pancreas and kidney disease and often their only hope for survival. Families of potential organ donors play a central role in the consent process yet little is known about what determines whether or...

Optimal Practices in Critical Care Neurology and Trauma

2016/17-2020/21 • $510,000 • PI
Traumatic brain injury is the leading cause of death and severe disabilities among young adults. Recommendations for prognosis assessment and optimal management are limited, clinical practices variable and rarely supported by evidence. Using a comprehensive approach, the Chair's program aims to...

Co-designing a Patient and Family Caregiver-Oriented Transitions in Care Bundle

2019/20-2020/21 • $503,540 • PI,CO,Other
Patients in the intensive care unit (ICU) are very sick. When a patient leaves the ICU they may have a change in their health that is new to them and their family members, such as new medical problems or new medications. When a patient leaves an ICU they can move to another part of the hospital...

Family-administered delirium detection in the critically ill

2018/19-2020/21 • $443,294 • PI,CO
Delirium is a brain condition in which patients become very confused and lose their ability to focus attention. Over half of the patients in intensive care units (ICUs) suffer from delirium during their ICU stay. Being older makes a patient more likely to develop delirium in the ICU. Research...

The Canadian Severe Acute Respiratory Infection, Prospective, Perpetual Observational Study: Informing Clinical Care and the Public Health Response

2020/21 • $303,450 • PI,CO
Severe acute respiratory infection (SARI) is a major public health problem. The commonest cause of SARI is influenza which is responsible for substantial illness and death each year, in addition to outbreaks and periodic pandemics. Recent outbreaks of pandemic influenza viruses and coronaviruses...

Addressing variation in practice in red blood cells transfusion for patients undergoing gastrointestinal cancer surgery.

2019/20-2020/21 • $221,347 • PI,CO
Red blood cell transfusions are common in patients receiving gastrointestinal surgery, however, they often cause significant harm, including increased risk of death, cancer recurrence and longer hospital stays. There exists significant evidence that shows restricting transfusions improves...

The Canadian Critical Care Trials Group

2020/21 • $150,000 • PI,CO,Other
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Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research

2019/20-2020/21 • $110,430 • PI,CO
What is the problem?: In research studies, clinicians and researchers measure specific signs of injury or recovery called 'outcomes' to measure success. In bleeds in the brain from a burst artery (called subarachnoid hemorrhage or 'SAH' for short), there is little consistency in reporting...

Therapeutic Plasma Exchange in Septic Shock: A Pilot Study

2020/21 • $100,000 • PI,CO
Septic shock, a life-threatening infection, is among the most common reasons for admission to intensive care units in Canada and is a leading cause of death. Septic shock leads to uncontrolled inflammation and blood clotting abnormalities that leads to death in up to up to 50% of patients. Apart...

The NeurO2 study: optimal brain oxygenation in neurocritically ill patients

2020/21 • $82,328 • PI,CO
Acute brain injury from trauma (TBI) or a burst artery in the brain (aSAH) often affects young people (40-60 years), nearly half of whom will die, and a third will have permanent disability. A particular challenge in managing these patients is that the recovering brain is very sensitive to low...

Audit & Feedback Module Targeting Low-Value Clinical Practices in Injury Care: an Economic Evaluation

2020/21 • $57,054 • PI,CO
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of injury deaths are estimated to be preventable and significant...

Canadian Traumatic brain injury Research Consortium (CTRC)

2015/16-2019/20 • $1,824,513 • PI,CO,Other
Traumatic brain injury (TBI) is the most common cause of death in the first half of life and the most frequent cause of long term handicaps for Canadians of all ages. TBI can be quite variable. Individuals who experience the mild form, called concussion, can appear normal on the outside but be...

The Canadian Critical Care Trials Group

2014/15-2019/20 • $1,500,000 • PI,CO,Other
The Canadian Critical Care Trials Group: We are a group of Canadian health care professionals from coast to coast who care for patients in the intensive care unit (ICU). Over the past 25 years, we have performed high quality research to enhance the care of critically ill patients and their...

Development and Evaluation of a Family-Partnered Care Pathway for Critically Ill Older Patients

2016/17-2019/20 • $1,388,754 • PI,CO,Other
ABSTRACT: As society ages, increasing numbers of older patients are being admitted to Intensive Care Units (ICU) for life-sustaining treatments. Historically, older critically ill patients have been systematically excluded from many clinical trials so there is very little evidence to inform what...

STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI)

2015/16-2019/20 • $1,177,472 • PI,CO
Acute kidney injury (AKI) represents a sudden decline in kidney function and is associated with a high risk of death. When AKI is severe, some patients require the initiation of kidney replacement therapy in the form of dialysis. Dialysis replaces the kidneys' usual functions by the removal of...

Heparin anticoagulation to improve outcomes in septic shock: The HALO International Phase II Trial

2017/18-2019/20 • $631,125 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The most common cause of death in patients admitted with life-threatening infections is multi-organ failure that is mediated...

Tranexamic acid during cystectomy trial (TACT)

2015/16-2018/19 • $394,050 • PI,CO
A cystectomy is the removal of the bladder and adjacent organs in patients with bladder cancer. This often results in significant blood loss, and about 60% of patients will require blood transfusion during surgery. Significant blood loss may result in cardiovascular morbidity, and the use of...

Tranexamic acid to reduce red blood cell transfusion in major non-cardiac surgery (TRACTION): A pragmatic, registry-based, pilot, randomized controlled trial

2018/19 • $100,000 • PI,CO,Other
Bleeding and the need for red blood cell transfusion is common in major surgical procedures. Transfusion associated with major surgery accounts for 50% of all transfused blood. Transfusion is expensive and blood is a scare resource. In preparation for large randomized control trial evaluating an...

Precision Fluid Biomarkers of Traumatic Brain Injury

2018/19 • $100,000 • PI,CO
Traumatic Brain Injury (TBI) is one of the most challenging brain disorders to study. TBI can happen to anyone at any time, at any level of severity. TBI spans a wide range of severity from mild (including concussions) to life-threatening injuries, and there is much uncertainty about how to...

Age of Blood in Children in Pediatric Intensive Care Units (ABC-PICU): a multicenter international pragmatic double blind randomized clinical trial on the efficacy of "short storage" red blood cell units to decrease the incidence of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children

2012/13-2017/18 • $1,163,162 • PI,CO
Presently, when red blood cell transfusion is required, blood banks transfuse the oldest unit available. In North America that means red cells stored up to 42 days may be transfused to critically ill children despite some concern that older blood may have negative effects. There is also a widely...

Cellular Immunotherapy for Septic Shock (CISS): A Phase II Trial

2017/18 • $100,000 • PI,CO
Severe infection with shock (septic shock) in the intensive care unit (ICU) is common accounting for approximately 20% of admissions, of which 30-40% will die. Septic shock is associated with an immensely uncontrolled inflammatory response from the body that is initiated by the infectious...

Early Determination of long-term Prognosis in critically ill patients with Severe Traumatic Brain Injury (TBI-Prognosis multicenter prospective study)

2012/13-2016/17 • $1,015,166 • PI,CO
Traumatic brain injury is the leading cause of death and severe disabilities among adults under 45 years of age. Most deaths following severe traumatic brain injury are related with the decision made by families and medical teams to withdraw life-sustaining therapies. Because severe traumatic...

Clinical outcomes and predictors of PITuitary disorders in patients with moderate and severe Traumatic Brain Injury: the PIT-TBI prospective multicenter pilot cohort study.

2014/15-2016/17 • $278,469 • PI,CO
Damage to the pituitary gland, located at the base of the brain, is a frequently overlooked but potentially important complication of traumatic brain injury (TBI). Disorders of the pituitary gland can cause dysfunction of the thyroid, adrenals, ovaries and testes. These disorders may occur...

Prognostic evaluation and level of care decisions in critically ill patients with traumatic brain injury

2015/16-2016/17 • $80,000 • PI
Traumatic brain injury is the leading cause of death and severe disabilities among adults under 45 years of age. Most deaths following severe traumatic brain injury are related with the decision made by families and medical teams to withdraw life-sustaining therapies. Because severe traumatic...

Evaluation of the association between hospital resource use intensity and quality of care in a trauma system

2016/17 • $10,318 • PI,CO
Unnecessary medical care costs Canadians $56 billion per year and increases patient mortality and morbidity. Trauma represents one of the most resource-intensive medical specialties with enormous potential for improvements in efficiency. However, only one study has evaluated costs for injury...

Canadian Critical Care Knowledge Translation Nework

2012/13-2015/16 • $599,611 • PI,CO,Other
The care of critically ill patients is a core function of hospitals. Critically ill patients are typically treated in Intensive Care Units (ICUs) and have high rates of mortality and prolonged disability. In addition, ICU care is a limited and expensive resource. The implementation of research...

Transfusion of Plasma Prior to Invasive Procedures Pilot Trial

2014/15-2015/16 • $232,244 • PI,CO
Frozen plasma is commonly transfused to patients with abnormal coagulation results prior to medical procedures associated with a risk of bleeding (e.g. involving a needle or incision). The most frequent group that requires frozen plasma transfusions are patients admitted to an intensive care...

Evaluation of blood transfusion strategies in neurocritically ill patients

2013/14-2015/16 • $105,000 • Scholarship/Fellowship,Other
Blood transfusions to correct anemia (low level of red blood cells) in critically ill patients have been of major importance in critical care over the last decades. Restrictive transfusion strategies (low red blood cells levels) have shown potential benefits over more liberal strategies (high...

Diagnostic Test Accuracy Review : Genomics-based non-invasive prenatal testing for detection of fetal chromosomal aneuploidy in pregnant women.

2015/16 • $100,000 • PI,Other
Each year over 450,000 Canadian women become pregnant and face difficult decisions about prenatal screening for Down syndrome. The current biochemical+ultrasound screening tests reach a sensitivity of 85% with a false positive rate of 4%. The large number of amniocenteses needed to be performed...

A National Strategy on Quality of Care Research and Evaluation - With the Patient for the Patient

2015/16 • $25,000 • PI,CO
Intensive care requires multidisciplinary teams that diagnose and provide care of patients with life-threatening conditions requiring sophisticated organ support and monitoring such as ventilator support, blood transfusions or dialysis when kidneys fail. Patients needing critical care range from...

Optimal VAsopressor TItratiON (OVATION) Pilot Randomized controlled Trial

2012/13-2014/15 • $379,077 • PI,CO
Patients who are admitted to intensive care units commonly suffer from illnesses that cause life-threatening low blood pressure. In this context, intensivists (physicians who care for patients in intensive care units) administer potent medications that increase blood pressure. Unfortunately,...

Heparin AnticoaguLation to improve Outcomes in septic shock: The HALO pilot

2012/13-2014/15 • $288,152 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The most common cause of death in patients admitted with life-threatening infections is multi-organ failure that is mediated...

A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury: (The RE-ENERGIZE Study)

2014/15 • $100,000 • PI,CO
Patients with severe burns need to recover in a hospital burn unit for a long time and are at high risk of developing infections and dying. Proper nutrition and certain nutrients may improve survival in these patients and shorten their stay in the burn unit. Glutamine is a building block of...

Structuring Patient-Oriented Research: Developing a National Agenda in Patient Care Research and Evaluation.

2014/15 • $25,000 • PI,CO
Critical care is essential to the Canadian healthcare system but it is very resource intensive. Its enormous human and financial cost underscores the pressing need for high quality evidence on effectiveness, an important aspect of quality care encompassing efficacy and cost. In Canada, up to 25...

Ancillary testing for diagnosis of brain death: a systematic review and meta-analysis

2013/14 • $98,447 • PI,CO,Other
Organ transplantation is for many patients with terminal heart, lung, liver and kidney disease the only hope for survival. In 2011, 4660 patients were on the waiting list for transplantation in Canada and 285 died waiting for an organ. For the purpose of organ donation, organs can be obtained...

Development and planning of a theory-based implementation of a national wiki-based reminder system promoting best practices in trauma care

2013/14 • $24,956 • PI,CO,Other
Computer-based reminder systems have been proven to be effective mechanisms for improving clinical practice in a variety of areas, including trauma care. They remind health professionals of the best practices to follow for many clinical conditions. Finding new ways to make sure that the people...

Developing trauma center performance indicators for nonfatal outcomes

2010/11-2012/13 • $193,816 • PI,CO
Injury is the leading cause of death in Canadians under 45 years of age, the leading cause of loss of active life years in Canadians under 70 years of age, and costs approximately $20 billion per year in Canada. The introduction of trauma systems, comprising a network of designated trauma...

A pilot randomized controlled trial to evaluate the efficacy of unfractionated Heparin in septic shock

2011/12-2012/13 • $50,000 • PI,CO
Life-threatening infections account for 10% of all intensive care unit admissions and constitute the second more frequent cause of death in the ICU after heart diseases. The cause of death in patients with life-threatening infections is often multi-organ failure that is mediated by severe...

Age of blood evaluation (ABLE) trial in the resuscitation of critically ill patients

2010/11-2011/12 • $2,091,670 • PI,CO
Background: No published clinical data demonstrate that older, stored red cells remain effective oxygen carriers or that prolonged red cell storage does not result in harm to vulnerable patients. Hypothesis: We hypothesize that the transfusion of fresh red blood cells will lead to a greater...

Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care for Octogenarians: The REALISTIC 80

2010/11-2011/12 • $497,339 • PI,CO
Every day in hospitals across Canada, frail elderly patients at or near the end of life are faced with decisions related to the use of life support machines. In a recent survey carried out at several large teaching hospitals across the country, seriously ill patients rated "not being prolonged...

Assessing Care of Patients with Major Traumatic Injuries

2010/11-2011/12 • $69,974 • PI,CO,Other
Each year, injuries affect 700 million people around the world including 30 million North Americans and 2 million Canadians. In Canada, injuries are the leading cause of death among those under the age of 45 years and account for more premature deaths than heart disease, lung disease or HIV...

EPITEC - Epidemiology of ThromboEmbolism in Critical care

2010/11-2011/12 • $60,000 • PI,CO
Blood clots that develop in veins of the legs or arms because of serious illness and inactivity may break off and travel to arteries in the lungs. Lung clots are extremely dangerous and are a leading cause of hospital death worldwide. The most seriously ill hospitalized patients on life support...

Wikis and collaborative writing applications in health care: a scoping review

2011/12 • $49,991 • PI,CO,Other
In developed and developing countries alike, vast numbers of healthcare decision-makers - providers, patients and policy-makers - are failing to use research evidence to inform their decisions. By involving knowledge users in knowledge dissemination, social media - highly accessible, interactive...

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