Mary Pat McAndrews


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Projets de recherche récents

Characterizing Adaptive Changes in Memory Networks for Medial Temporal Lobe Epilepsy Before and After Surgical Resection of the Epileptic Focus

2016/17-2020/21 • $596,170 • PI
Individuals with left-temporal lobe seizures who do not respond to medication can benefit from surgery that removes the epileptic focus. These regions are also very important for memory, and over 50 years of research shows considerable heterogeneity amongst patients in the degree to which memory...

Baseline brain and behavioural predictors of treatment response in pediatric MSK pain

2019/20-2020/21 • $210,430 • PI,CO
Chronic pain affects one in five Canadian children. In particular, musculoskeletal (MSK) pain is one of the leading causes of long-term disability. Pain, which normally exists to protect the body, sometimes transitions to chronic pain, a disease state. This transition is poorly understood....

Cognitive assays of hippocampal dysfunction in Parkinson's Disease

2019/20-2020/21 • $153,122 • PI,CO
In addition to physical symptoms, people with Parkinson's disease often experience cognitive decline with the progression of their illness and as a side-effect of therapies such as deep brain stimulation (DBS). There is marked heterogeneity in the rate and degree of cognitive decline across...

Pain sensitivities in patients with mesial temporal lobe epilepsy

2019/20-2020/21 • $105,000 • Scholarship/Fellowship,Other
Patient H.M. revolutionized our understanding of how memory is processed in the brain, but could he also be the key to our future understanding of pain? In 1957, both of his medial temporal lobes (MTL) were removed to cure his epilepsy. Following his surgery, Patient H.M. developed dementia, and...

Cognitive assays of hippocampal dysfunction in Parkinson's disease

2018/19 • $100,000 • PI,CO
In addition to physical symptoms, people with Parkinson's disease often experience cognitive decline with the progression of their illness and as a side-effect of therapies such as deep brain stimulation (DBS). There is marked heterogeneity in the rate and degree of cognitive decline across...

Human studies on the neuropsychology and cognitive/behavioural neuroscience of memory and its disorders.

2012/13-2017/18 • $924,841 • PI,CO
How do memories change with time and what are the neural mechanisms that are associated with these changes? It is well known that as time passes, memories of some experiences retain the same vivid qualities that they had shortly after the experience occurred. Other memories, however, fade with...

A qualitative study of caregiver and patient perspectives on ethical and social issues in deep brain stimulation for Parkinson's disease and neuropsychiatric disorders

2010/11-2012/13 • $241,800 • PI,CO
Deep-brain stimulation (DBS) is a viable treatment for Parkinson's disease (PD) and Essential Tremor (ET) that offers advantages over drug therapy, especially for later disease stages. Since the approval of this latter technology by the FDA in 1997, over 35 000 patients in numerous countries...

Spatial and temporal characterization of hippocampal memory processes: studies in the normal brain and individuals with medial temporal-lobe epilepsy and excisions

2010/11-2011/12 • $197,803 • PI,CO
Regions of the brain, especially those located in the temporal lobes, are crucial to storing and recalling memories that are rich in associations, including events from one's personal past. Although there are many conditions that can affect such memory, little is known about how different areas...

Neuroimaging studies of hippocampal formation in children with pre-and postnatal thyroid hormone insufficiencies

2010/11 • $145,728 • PI,CO
Thyroid hormone (TH) is essential for early brain development, particularly the hippocampus, a structure critical for episodic memory. Although research on children with pre- or neonatal TH deficiencies reveals memory difficulties suggesting abnormal hippocampal development, the...

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