Anthony J. Hanley


Contact via University of Toronto


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Projets de recherche récents

Fundamental and Translational Studies of Diabetic Dyslipidemia in Insulin Resistant States

2016/17-2020/21 • $1,925,694 • PI,Other
I have been a senior scientist in both basic scientific and clinical research for over 25 years. Due to numerous achievements and publications, my laboratory is now recognized as a leader in both fields with major national and global impact. The main focus of my research program has been to...

Progression to Type 2 Diabetes in the 1st Decade after Glucose Intolerance in Pregnancy: Pathophysiology and Clinical Implications

2018/19-2020/21 • $565,199 • PI,CO
Gestational diabetes mellitus (GDM) is defined as high blood sugar that is first recognized during pregnancy. It is a common condition affecting up to 14% of pregnant women. Importantly, women who have had GDM are at increased risk of developing type 2 diabetes (T2DM), particularly within the...

Metabolic impact of intermittent fasting in early type 2 diabetes

2019/20-2020/21 • $207,761 • PI,CO
Background: Intermittent fasting (IF) interventions in which no food is consumed over a period of time have been recently studied in individuals with obesity and shown to be beneficial. One previous study demonstrated that IF can make the beta-cells of the pancreas, which make insulin for the...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Enhancement and Adaptation of Community-driven Innovations and Scale-up Toolkits

2016/17-2019/20 • $652,110 • PI,CO,Other
In Canada, there are significant disparities between the health status of Indigenous peoples and the general population with respect to diabetes. Community-driven innovations, activated by quality improvement processes, have the potential to reform local healthcare. The goal of the proposed...

The role of soluble CD163, a marker of adipose tissue macrophage activation, in the etiology of type 2 diabetes.

2018/19-2019/20 • $105,000 • Scholarship/Fellowship,Other
Overweight and obesity is the most well-established and impactful risk factor for the development of type 2diabetes mellitus (T2DM). Although a number of potential mechanisms have been suggested to explain the obesity-diabetes link, a great deal of research over the past 2 decades has focused on...

Expanding the Circle: Peer-based approaches to obesity and type 2 diabetes prevention for Indigenous children

2015/16-2018/19 • $675,000 • PI,CO,Other
Type 2 diabetes and obesity are 3-5 times more common among Indigenous children, compared to non-Indigenous children in Canada. The inequities in diabetes and obesity can be traced back to several forms of transgenerational stress and adversity that accompanies social determinants of health....

Understanding the effects of social, behavioural and metabolic factors on early childhood growth trajectories among Aboriginal Canadians

2012/13-2017/18 • $793,318 • PI,CO
Adult onset (type 2) diabetes is a major public health challenge for First Nations communities in Canada. This condition often leads to long term complications, reduced quality of life and early death. For almost 20 years, Sandy Lake First Nation and health researchers at the Universities of...

Postpartum Progression to Type 2 Diabetes in Women with Recent Glucose Intolerance in Pregnancy: Pathophysiology, Biomarkers, and Clinical Implications

2012/13-2017/18 • $754,017 • PI
Gestational diabetes mellitus (GDM) is defined as high blood sugar that is first recognized during pregnancy. It is a common condition affecting up to 14% of pregnant women. Importantly, women who have had GDM are at increased risk of developing type 2 diabetes (T2DM), particularly within the...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Community-driven Innovations and Strategic Scale-up Toolkits

2013/14-2016/17 • $2,500,000 • PI,CO,Other
In Canada, significant disparities between the health status of Indigenous peoples and the general population exist, particularly for chronic diseases such as diabetes. There is a pressing need to shift the present episodic care focus common to most First Nations communities, to one that...

The Epidemiology of Type 2 Diabetes

2011/12-2016/17 • $500,000 • PI
There is currently a global epidemic of adult-onset diabetes. Although fewpopulations have been spared increases in diabetes rates, several groups carry adisproportionate burden, including Aboriginal Canadians and people of Hispanic andAfrican origin. In addition, disorders including the...

Transformation of Indigenous Primary Healthcare Delivery (FORGE AHEAD): Enhancement and Adaptation of Community-driven Innovations and Scale-up Toolkits

2016/17 • $5,744 • PI,CO,Other
Given the dramatic rise and impact of chronic disease and gaps in care in Indigenous communities, a shift from the existing episodic healthcare model common in Indigenous communities to one that integrates prevention and chronic disease management is needed. To assist with this transition, the...

PROMOTE: Preschoolers at Risk - Obesity trajectories & cardioMetabolic factors: Towards Early identification

2011/12-2015/16 • $655,641 • PI,CO
The metabolic syndrome is a group of factors including obesity, and abnormalities in blood pressure, insulin, and cholesterol that has been shown to be associated with type 2 diabetes and heart disease in adults. There is emerging evidence that rapid growth in early childhood increases the risk...

Plasma non-esterified fatty acids and the progression of insulin resistance and pancreatic beta-cell dysfunction: a novel targeted omics approach.

2013/14-2015/16 • $249,498 • PI,CO
Elevations in total blood free fatty acids can be used to predict the risk of developing insulin resistance, which increases the risk of type 2 (adult-onset) diabetes mellitus. In the blood, fatty acids are found in specific compartments, commonly called pools. Furthermore, about 25 fatty acids...

The Aboriginal Youth Mentorship Program - Exploring the Potential for Dissemination Across Multiple Settings

2014/15 • $11,800 • PI,CO,Other
Obesity and type 2 diabetes (T2D) are two of the most common chronic diseases in youth and disproportionately affect indigenous youth from all continents. Unfortunately, few interventions grounded in Indigenous teachings exist to reduce these statistics. We have developed a peer-led afterschool...

Insulin resistance and beta cell dysfunction in early childhood: the role of maternal and infant metabolic risk factors

2010/11-2013/14 • $322,072 • PI,CO
Infants born to women with diabetes diagnosed during pregnancy are at an increased long-term risk of developing obesity and diabetes which results, in part, from the effects of exposure to high blood sugars before birth. High blood sugars during pregnancy may result in reprogramming of important...

Strategic Planning to Support First Nations Communities Participating in the FORGE AHEAD Program

2013/14 • $24,997 • PI,CO,Other
The proposed planning activities, including a face-to-face meeting, will enhance existing partnerships as well as foster the development of new partnerships by bringing together members of a national steering committee that includes First Nations (FN) community representatives, academic...

CIHR Team in Childhood Obesity Research

2010/11-2012/13 • $1,420,739 • PI,CO
Childhood overweight and obesity has reached epidemic levels in Canada, and the problem continues to worsen. There are important health consequences for overweight children, including high blood pressure, high cholesterol, diabetes and bone and joint problems, as well as psychologic problems...

Longitudinal associations of adipocytokines and markers of sub-clinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational Diabetes Mellitus

2010/11-2012/13 • $320,612 • PI
Gestational diabetes mellitus (GDM) is defined as high blood sugar that is first recognized during pregnancy. It is a common condition affecting up to 14% of pregnant women. Those who have had GDM are at increased risk of getting adult-onset (type 2) diabetes (DM). In fact, many women who have...

Preventing childhood obesity: early intervention during pregnancy and first year postpartum for overweight and obese women using a two-pronged family-based Nutrition & Exercise Lifestyle Intervention Program (NELIP)

2010/11-2011/12 • $198,592 • PI,CO
Our longitudinal aim is to reduce childhood obesity using our two-pronged intervention program, which includes healthy food choices and increased physical activity initiated during pregnancy and re-instated in the early period after delivery for overweight and obese women. We will accomplish...

Canada Research Chair in the Epidemiology of Type 2 Diabetes

2010/11-2011/12 • $150,000 • PI
There is currently a global epidemic of adult-onset diabetes. Although few populations have been spared increases in diabetes rates, several groups carry a disproportionate burden, including Aboriginal Canadians and people of Hispanic and African origin. In addition, disorders including the...

Understanding the Importance of Newly Identified Diabetes Risk Factors among Aboriginal Canadians: The Sandy Lake Health and Diabetes Project

2011/12 • $100,000 • PI,CO
Adult onset (type 2) diabetes is a major public health challenge for First Nations communities in Canada. This condition often leads to long term complications, reduced quality of life and early death. For almost 20 years, Sandy Lake First Nation and health researchers at the Universities of...

Vitamin D and the Early Pathophysiology of Type 2 Diabetes in Women with a History of Gestational Diabetes

2011/12 • $98,483 • PI,CO
Young women of childbearing age represent the segment of the Ontario population that has experienced the greatest increase in the prevalence of type 2 diabetes in the past 15 years. One group of young women who are at particularly high risk of getting type 2 diabetes consists of those women that...

The Role of Vitamin D in the Underlying Disorders of Type 2 Diabetes

2010/11-2011/12 • $70,000 • Scholarship/Fellowship,Other
Type 2 diabetes mellitus (DM) is a serious public health problem, and places a major burden on the health care system. The two primary disorders underlying type 2 DM are insulin resistance (IR) and beta-cell dysfunction. Although some of the causes of IR and beta-cell dysfunction have been...

The impact of gestational diabetes mellitus on breast milk and infant metabolic development

2010/11-2011/12 • $70,000 • Scholarship/Fellowship,Other
Childhood obesity has grown into an epidemic which is reflected in the soaring rate of diabetes. This phenomenon has left public and health providers to ponder whether heart disease is initiated as early as in infancy. The most preferred food during infancy is human breast milk which contains...

First Nations Community-Based Chronic Disease System Improvment Strategy - Planning Grant

2011/12 • $24,999 • PI,CO
The purpose of this application is to request funding for a series of planning meetings that will be used to form a national, interdisciplinary research team with expertise in First Nations health and to develop a submission for the Team Grant in Community-Based Primary Healthcare. The...

CIHR Team in a community-based intervention to reduce obesity through increasing fruits, vegetables, whole grains and reducing sweetened soft drinks.

2010/11 • $457,915 • PI,CO
Our objective is to focus advice to consume more fruit, vegetables and whole grains to achieve the desired goals of effectiveness in reducing risk factors for chronic disease including blood lipids, blood pressure, body weight, waist circumference, and insulin resistance. The increased focus...

The sandy lake health and Diabetes project: Understanding and addressing metabolic syndrome, Diabetes and associated complications in aboriginal Canadians

2010/11 • $205,156 • PI,CO
Adult onset (type 2) diabetes is a major public health challenge for First Nations communities in Canada. This condition often leads to long term complications, the most important of which is heart disease. However, diabetes can also cause problems with the feet, kidneys and eyes. For over 14...

Examining Diabetes in Children and the lifestyle and metabolic determinants.

2010/11 • $17,500 • Scholarship/Fellowship,Other
Not application.

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