Benoît R. Mâsse



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Chercheur(e)s associé(e)s
Organisations associées

Projets de recherche récents

Unité SUPPORT du Québec : Un soutien pour la recherche axée sur le patient

2014/15-2020/21 • $23,587,002 • PI,CO,Other
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Processus d'aide à la décision, gestion du RISque obstétrical et du Mode d'Accouchement après césarienne au Québec (PRISMA)

2015/16-2020/21 • $2,968,255 • PI,CO
Le taux de cesariennes ne cesse d'augmenter au Canada. Depuis les annees 2000, il est passe de 21,2 a plus de 26%. L'indication d'antecedent de cesarienne contribue a elle seule a plus de 30% des cesariennes totales. Chaque annee, environ 30 000 femmes au Canada avec un antecedent de cesarienne...

Vitamin D In the prevention of Viral-induced Asthma of preschoolers (DIVA): a multicentre randomized controlled trial

2017/18-2020/21 • $2,759,874 • PI,CO
Colds are the main cause of asthma attacks in preschoolers, an age group with the highest rate of visits to the emergency room because of asthma. The best strategy to prevent asthma attacks caused by colds is still unclear. Most children with asthma have low blood levels of vitamin D and this...

Sino-Canada HeLTI: A Multifaceted Community-Family-Mother-Child Intervention Study for the Prevention of Childhood Obesity

2016/17-2020/21 • $2,427,150 • PI,CO,Other
The epidemics of obesity and metabolic syndrome related disorders are a major public health concern. Increasing evidence points to the role of early life adverse factors in the developmental origins of the vulnerability to such metabolic disorders. Reducing the risk of overweight and obesity...

CRISM-Quebec-Maritimes: Research on interventions in drug misuse

2014/15-2020/21 • $2,374,845 • PI,CO,Other
Substance misuse remains a significant global public health problem which carries a heavy burden for abusers and their families alike. This disorder is indeed associated with suffering and severe health problems in patients, distress among family members, as well as tremendous costs to society....

Evaluating the differential impact of what we have done, as we prioritize what to do next: a multi-provincial intervention modeling study using population-based data

2020/21 • $1,293,631 • PI,CO
In Canada, as elsewhere, the COVID-19 epidemic has spread at varying speeds and amplitudes across people, places, and time. Early model predictions were dire across the board largely because of limited local data. So early models had to assume that we were all at equal risk, regardless of...

Coûts des maladies cardiovasculaires et des problèmes de santé mentale attribuables aux contraintes psychosociales au travail : Une étude longitudinale de 22 ans auprès de 9 000 cols blancs.

2016/17-2020/21 • $960,925 • PI,CO
Contexte: A l'echelle mondiale, les maladies cardiovasculaires (MCV) constituent la 1ere cause de mortalite et les problemes de sante mentale (PSM) constituent la 3ieme cause de morbidite. Il est maintenant reconnu que les contraintes psychosociales au travail contribuent au developpement des...

Effectiveness of Interventions in Early Daycare to Prevent Disruptive Behaviours in Children of Low-Income Neighbourhoods (I-CARE): A 2x2 Factorial Cluster Randomized Controlled Trial.

2018/19-2020/21 • $766,326 • PI,CO
Disruptive behaviour problems (DBPs) violate social norms and generate high costs to society. Adults with DBPs have problems ranging from mental health issues to substance abuse, spousal abuse, depression, and suicide. Disruptive behaviours begin in early childhood. Toddlers do not know how to...

Équipe de cliniciens-chercheur sur la Recherche en prématurité : vers un dépistage précoce et une prise en charge personnalisée.

2016/17-2020/21 • $765,645 • PI,CO
La naissance prematuree, c'est-a-dire qui survient avant 37 semaines de grossesse, touche environ 1 naissance sur 10. C'est une cause importante de deces des nouveau-nes. La prematurite a un impact important pour les couts de la societe et pour les familles. Il y a deux causes principales de...

Vers une optimisation de la thérapie cognitivo-comportementale axée sur le trauma pour le traitement l'état de stress post-traumatique et les problèmes connexes

2016/17-2020/21 • $759,721 • PI,CO
Le trouble de stress post-traumatique (TSPT) est un trouble psychiatrique repandu au sein de la population canadienne. La presente etude vise a evaluer l'efficacite et les retombees de deux nouvelles therapies psychologiques, basees sur les criteres diagnostiques du DSM-5, aupres d'une...

Development and Validation of a clinical prediction rule to guide and improve the treatment of female stress urinary incontinence

2016/17-2020/21 • $639,314 • PI,CO
Urinary incontinence (UI) afflicts 1 in 3 women 18 years and over. The most common type is stress UI which is accidental urine leakage during coughing, sneezing and physical activity. UI can lead to significant social problems, embarrassment, and negative self-perception; reduces social...

The Fit-for-Fertility Multicenter Randomized-Controlled Trial: Improving Reproductive, Maternal and Neonatal Outcomes in Women with Obesity and Infertility

2018/19-2020/21 • $590,729 • PI,CO
Obesity in infertile women increases the costs of fertility treatments, reduces their effectiveness and increases significantly the risks of many complications of pregnancy for the mother and the newborn. In Canada, 44% of women of reproductive age (20 to 44 years) were reported as being...

From Birth to Adulthood: The Risk and Protective Factors Leading to Mental Health Problems (MHPs) in a Representative Population Sample.

2016/17-2020/21 • $475,022 • PI,CO
While physical illnesses account for most of the social and economical burden among adults, Mental Health Problems (MHPs) are the first cause of disability among youths (18-25 years). Youth with MHPs such as substance abuse, antisocial behaviour, and depression are at high risk for school...

Pilot study of a community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast cancer survivors

2019/20-2020/21 • $191,250 • PI,CO
Context: Adjuvant endocrine therapy (AET) is an oral medication prescribed to women with hormone-sensitive breast cancer (75% of cases) to reduce recurrence and mortality risks. Suboptimal AET adherence is common: 31% to 47% of women do not persist with AET for the 5 years minimally recommended....

A 15 months, double-Blind, randomized controlled trial comparing 18 weeks of two doses of Omalizumab to placebo to accelerate a symptom-driven Oral immunotherapy schedule in subjects aged 6 to 25 years with Multiple food allergies (BOOM).

2019/20-2020/21 • $146,901 • PI,CO
Oral immunotherapy (OIT) is a new treatment for food allergy, where allergists administer patients precisely measured amounts of their allergen to progressively deplete antibodies on allergy cells and build their tolerance over time up to a full portion of the food. While creating hopes for tens...

Reducing chronic stress in toddlers and preschoolers: A randomized controlled trial of interventions to improve social behaviors in daycare and parenting practices at home

2020/21 • $117,214 • PI,CO
Preschoolers are exposed to many stressful situations at home and daycare. This is especially true for children who manifest disruptive behaviours or live in low-income neighbourhoods. Sources of stress include fights for a toy with a sibling or peers, exclusion from games at daycare, and harsh...

COVID-19 Variant Network - Evaluating the differential impact of what we have done, as we prioritize what to do next: a multi-provincial intervention modeling study using population-based data

2020/21 • $100,000 • PI,CO
In Canada, as elsewhere, the COVID-19 epidemic has spread at varying speeds and amplitudes across people, places, and time. Early model predictions were dire across the board largely because of limited local data. So early models had to assume that we were all at equal risk, regardless of...

HPV vaccination effectiveness in a Canadian setting, 12 years after implementation: are we on the road to eliminate cervical cancer?

2020/21 • $78,412 • PI,CO
In Canada, screening has helped to reduce the number of cervical cancer cases. However, there were still 1350 women diagnosed with cancer and 410 deaths in 2019. Persistent infections of high-risk HPV types can lead to the development of precancerous lesions that may slowly transform into...

COVID-19 Variant Supplement - Evaluating the differential impact of what we have done, as we prioritize what to do next: a multi-provincial intervention modeling study using population-based data

2020/21 • $50,000 • PI,CO
In Canada, as elsewhere, the COVID-19 epidemic has spread at varying speeds and amplitudes across people, places, and time. Early model predictions were dire across the board largely because of limited local data. So early models had to assume that we were all at equal risk, regardless of...

Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized Controlled Trial (MOBYDIck Trial)

2014/15-2019/20 • $2,626,763 • PI,CO
Every year in Canada, 1500 babies who are born early (prematurely) develop a serious lung disease called bronchopulmonary dysplasia (BPD). BPD causes major health problems in these infants, especially in their early childhood. In most situations, breast-milk is the ideal source of nutrition for...

Exposition cumulée aux stresseurs psychosociaux, marqueurs inflammatoires, télomères et fonction cognitive : Une étude prospective de 20 ans

2014/15-2019/20 • $781,921 • PI,CO
Des etudes rapportent que l'exposition au stress chronique au travail (contraintes psychosociales) contribue au developpement de problemes de la memoire (fonction cognitive) avec l'age. L'inflammation et l'oxydation sont deux mecanismes d'action impliques dans le vieillissement. Des marqueurs...

Pilot Optimizing Transfusion Thresholds in Critically-ill Children with Anaemia (P-OpTTICCA): a pilot trial for a large pragmatic international parallel open-label non-inferiority randomised controlled trial.

2019/20 • $198,900 • PI,CO
Une transfusion peut s'averer benefique chez les enfants les plus malades, comme ceux traites en soins intensifs, mais les complications sont aussi plus frequentes dans cette population. On sait deja avec certitude qu'il faut transfuser un enfant anemique hospitalise si sa concentration sanguine...

First-trimester prediction of preeclampsia and other placenta-mediated pregnancy complications

2014/15-2018/19 • $979,594 • PI,CO
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death. Several measures are used of under investigation (low-dose aspirin, low-molecular weight heparin, calcium, folic acid, among others) for the...

Étude pilote sur l'association du pessaire et de la progestérone afin de prévenir la prématurité spontanée.

2016/17-2018/19 • $374,606 • PI,CO
La prematurite est une des principales causes de mortalite et de morbidite perinatale. Les consequences economiques de la prematurite sont considerables dans l'ensemble des pays developpes. La prevention est tres importante car elle seule peut reellement etre efficace. Actuellement le meilleur...

A cluster randomised trial investigating the effects of delaying onset of substance use on adolescent cognitive development.

2011/12-2017/18 • $1,201,878 • PI,CO
Empirical studies indicate that early onset substance misuse is associated with long-term negative outcomes, including greater risk for addiction, school drop-out, mental illness and poor physical health. However, it is unclear how early onset substance use translates to future risk. This...

Inégalités sociales de santé mentale, contraintes psychosociales au travail, vie active et retraite: une étude prospective de 20 ans

2014/15-2017/18 • $741,833 • PI,CO
Les problemes de sante mentale (PSM) constituent la 3e cause de morbidite dans le monde. De plus, ces problemes constituent une des principales causes d'incapacite et d'absences du travail de longue duree dans les pays developpes. Les groupes ayant un faible statut socio-economique sont plus...

The impact of beta-amyloid burden on cognition in normal aging

2012/13-2017/18 • $710,453 • PI,CO
Alzheimer's disease (AD) is the leading cause of dementia in Canada. Because the Canadian population is growing older and because age represents the greatest risk factor of developing the disease, it is important to better understand the differences between normal aging and the earliest signs of...

Risk of Chronic Diseases in Young Adults Born Preterm: Relationship with Inflammation and Oxidative Stress Biomarkers

2014/15-2017/18 • $471,215 • PI,CO
In Canada, 8% of births are preterm (< 37 weeks) and 1% occur < 29 weeks. Technological advances have improved survival of preterm infants, thus continuously increasing the absolute number of young adults born preterm. Neurodevelopmental outcomes of prematurity have been extensively studied but...

Genomic determinants of common long-term treatment effects in childhood acute lymphoblastic leukemia survivors

2011/12-2016/17 • $2,895,054 • PI,CO
Acute lymphoblastic leukemia (ALL) is the most frequent cancer in children, accounting for approximately 25% of all pediatric tumors. Advances in our understanding of the pathobiology of this cancer and of its treatment have led to increased survival rates with ~80% of cases being cured with...

From Birth to Adolescence: The Developmental Trajectories Leading to Mental Health Problems in a Representative Population Sample.

2011/12-2016/17 • $917,000 • PI,CO
While physical illnesses account for most of the social and economical burden among adults, mental health problems are the first cause of disability among youths. The prevalence of mental health problems in children and adolescents is higher than previously thought. Point estimates in the past...

Water Schools (WS): a knowledge-to-action framework that promotes tap water consumption and discourages sugar-containing beverages among school-age children

2016/17 • $100,000 • PI,CO
Children have access to tap water in schools, but its not always their first drink choice because of competition from sugary drinks and bottled water-an unsustainable environmental practice. Knowing that: - Many children are overweight or obese by adolescent; - Unhealthy drinking habits develop...

Sino-Canada HeLTI: A Multifaceted Community-Family-Mother-Child Intervention Study for the Prevention of Childhood Obesity

2016/17 • $35,000 • PI,CO,Other
The epidemics of obesity and metabolic syndrome related disorders are a major public health concern. Increasing evidence points to the role of early life adverse factors in the developmental origins of the vulnerability to such metabolic disorders. Reducing the risk of overweight and obesity...

Inégalités sociales, environnement psychosocial au travail, vie active, retraite et santé cardiovasculaire: une étude prospective de 20 ans chez 9000 femmes et hommes

2011/12-2015/16 • $617,448 • PI,CO
A l'echelle mondiale et au Canada, les maladies cardiovasculaires (MCV) comptent pour le tiers des deces des femmes et des hommes. Le risque de developper une MCV et le risque d'avoir une pression arterielle elevee augmentent a mesure que le statut socio-economique (c'est-a-dire la scolarite,...

A randomized clinical trial of Oral analgesics Utilization for CHildhood musculoskeletal injuries (The OUCH Trial)

2012/13-2015/16 • $584,860 • PI,CO
Pain management of children presenting to the Emergency Department (ED) with a trauma to a limb is poorly treated even though musculoskeletal traumas (e.g. fractures, severe sprains) are considered to generate moderate to severe pain intensity. In spite of the fact that pain is considered one of...

QUAlité des soins, gestion du RISque obstétrical et du Mode d'Accouchement au Québec (QUARISMA) : Des connaissances à la pratique

2014/15-2015/16 • $199,944 • PI,CO,Other
La diminution du recours aux interventions obstetricales non medicalement requises est un objectif cible par la Politique de perinatalite 2008-2018 du Ministere de la Sante et des Services Sociaux du Quebec et constitue une priorite pour les annees 2009-2013. La Politique precise la necessite...

Vitamin D In the prevention of Viral-induced Asthma of preschoolers: a RCT (DIVA)

2015/16 • $100,000 • PI,CO
Colds are the main cause of asthma attacks in preschoolers, an age group with the highest rate of visits to the emergency room because of asthma. The best strategy to prevent asthma attacks caused by colds is still unclear. Most children with asthma have low blood levels of vitamin D, and this...

Targeting impulsivity in early childhood in the prevention of externalizing psychopathology: Using RCT to test developmental models of individual (biology/dispositional) factors by environment interaction

2015/16 • $100,000 • PI,CO
Childhood externalizing disorders (EDs), such as ADHD and conduct disorder, are widespread, persistent, and costly to society. EDs in childhood are major risk factors for adult mental health and substance use disorders, school-drop out, crime and violence. EDs often co-occur, and share common...

Multicenter pilot study on assessment and prevention of platinum-induced ototoxicity

2012/13-2014/15 • $239,476 • PI,CO
Recent advances in cancer treatment are leading to rapidly increasing survival rates. The current five-year survival rate for children with cancer is 80%. Cisplatin and carboplatin are two of the most successful and widely-used anticancer drugs; however, they lead to ototoxicity in the majority...

Processus d'aide à la décision, gestion du RISque obstétrical et du Mode d'Accouchement après césarienne au Québec (PRISMA)

2014/15 • $100,000 • PI,CO
Le taux de cesariennes ne cesse d'augmenter au Canada. Depuis les annees 2000, il est passe de 21,2 a plus de 26%. L'indication d'antecedent de cesarienne contribue a elle seule a plus de 30% des cesariennes totales. Chaque annee, environ 30 000 femmes au Canada avec un antecedent de cesarienne...

Vitamin D In the prevention of Viral-induced Asthma of preschoolers: a RCT (DIVA)

2014/15 • $100,000 • PI,CO
Colds are the main cause of asthma attacks in preschoolers, an age group with the highest rate of visits to the emergency room because of asthma. The best strategy to prevent asthma attacks caused by colds is still unclear. Most children with asthma have low blood levels of vitamin D, and this...

Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized Controlled Trial (MOBYDIck Trial)

2014/15 • $100,000 • PI,CO
Every year in Canada, 1500 babies who are born early (prematurely) develop a serious lung disease called bronchopulmonary dysplasia (BPD). BPD causes major health problems in these infants, especially in their early childhood. In most situations, breast-milk is the ideal source of nutrition for...

CRISM-QUÉBEC: Réseau Québécois -Recherche sur les interventions en abus de substances/Research on Interventions for substance misuse

2013/14 • $49,832 • PI,CO,Other
Substance misuse remains a significant global public health problem which carries a heavy burden for abusers and their families alike. This disorder is associated with suffering and severe health problems in patients, distress among family members, as well as tremendous costs to society....

YouthCan 2020: A new vision for youth mental health in Canada

2013/14 • $25,000 • PI,Other
The majority of serious mental illnesses and addictions begin during adolescence. It is clear that the effectiveness of early intervention is limited by the barriers that youth face in accessing mental health/addiction services and by the often ineffective delivery of services. This has led to a...

Mobiliser les savoirs et les communautés pour une approche intégrée de la prévention du VIH et de la promotion de la santé sexuelle des hommes gais ou ayant des relations sexuelles avec d'autres hommes.

2013/14 • $10,000 • PI,CO,Other
Les hommes gais ou HRSH, comparativement aux hommes heterosexuels, presentent plus de problemes de sante mentale, de violence conjugale, d'habitudes de vie nefastes, de troubles alimentaires ou de probleme d'image corporelle et d'infection par le VIH et autres ITSS. Or, chacun de ces problemes...

Recherche interventionnelle pour la prévention des maladies chroniques en milieu de travail

2010/11-2011/12 • $147,996 • PI,CO
Cette recherche a pour objectif d'evaluer une intervention preventive visant la reduction des stresseurs psychosociaux et de leur impact sur des maladies frequentes dans la population canadienne : l'hypertension, les troubles musculosquelettiques et les problemes de sante mentale. L'intervention...

Estimation de la macrosomie fœtale chez les populations Cris de l'Est de la Baie James

2010/11-2011/12 • $81,437 • PI,CO
Le taux de macrosomie fœtale se situe entre 16 et 36% parmi les populations autochtones, compare a 11% dans la population nord americaine. La macrosomie fœtale represente un important facteur de risque de complications maternelles et perinatales, comme la dystocie des epaules et la lesion du...

From Birth to Adolescence: The Developmental Trajectories Leading to Mental Health Problems in a Representative Population Sample.

2010/11 • $100,000 • PI,CO
While physical illnesses account for most of the social and economical burden among adults, mental health problems are the first cause of disabilities among youths. The prevalence of mental health problems in children and adolescents is even higher than previously thought, with rates as high as...

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