Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).

Renseignements sur le financement
Natural Sciences and Engineering Research Council of Canada
  • Type de subvention: Projets de recherche concertée sur la santé
  • Années: 2013/14 à 2014/15
  • Financement total: $169,101
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Sommaire du projet

Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a seriesof aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, ontarget, on-mechanism lead suitable for development into a therapeutic agent.