Overcoming antibiotic resistance through the inhibition of aminoglycoside phosphotransferases (APH).
Renseignements sur le financement
Natural Sciences and Engineering Research Council of Canada
- Type de subvention: Projets de recherche concertée sur la santé
- Années: 2013/14 à 2014/15
- Financement total: $169,101
Aucun domaine de recherche n’a été trouvé.
Multidrug resistant microbes have become one of the top global health challenges and place a massive burden on theCanadian health care system. One approach to overcome this problem involves inhibiting the enzymes responsible forconferring resistance to the antibiotic. We have recently discovered a family of compounds that blocks the action of a seriesof aminoglycoside phosphotransferases (APH) and wish to develop the compounds to ultimately provide an optimized, ontarget, on-mechanism lead suitable for development into a therapeutic agent.