PROphylaxis for venous ThromboEmbolism in Severe Traumatic brain injury (PROTEST): a Double-blind Randomized Controlled Trial

Renseignements sur le financement
Canadian Institutes of Health Research
  • Type de subvention: Subvention Projet
  • Années: 2018/19 à 2020/21
  • Financement total: $1,938,143
Mots clés
Chercheur(e) principal(e)

Aucune organisation partenaire n’a été touvée.

Sommaire du projet

Severe traumatic brain injury is common, potentially lethal, and can result in severe and irreversible disability. It is also often associated with potentially life-threatening complications during the early period following the injury, when patients are critically ill and receiving life support. One of these complications is the development of clots in the legs and the lungs because the patients are not moving. Injectable clot prevention medications (anticoagulants) can help prevent these clots from forming, but there is a risk that these may increase the risk of progression of brain bleeding early after the injury. Currently, there is debate about the best timing to start these medications: as soon as possible during the first week after the brain injury, or waiting until at least 7 days after the brain injury. This study will help doctors determine which of these two approaches is better: early use of the medications to reduce the risk of clot, versus withholding these medications until one week after the brain injury to reduce the risk of bleeding. Both of these options have competing risks and benefits. This study will involve 11 of the largest major Canadian Trauma hospitals, and will provide valuable information to help improve outcomes for these critically ill patients.

Recherche connexe

Nearly 350,000 Canadians have been diagnosed with COVID-19 infection. In Canada, the elderly have been particular vulnerable, with long-term care homes experiencing the greatest burdens of illness and mortality. Civil society and our usual social fab... Plus ...
Patients with severe burns need to recover in a hospital burn unit for a long time and are at high risk of developing infections and dying. Proper nutrition and certain nutrients may improve survival in these patients and shorten their stay in the bu... Plus ...