High throughput culturing system for evolutionary engineering

Natural Sciences and Engineering Research Council of Canada

• Type de subvention: Outils et instruments de recherche - catégorie 1 (<150 000$)
• Année: 2010/11
• Financement total: $126,760

• Génie biochimique
• Génie chimique
• Ressources minérales (prospection, exploration, mines, extraction et préparation)
• Ressources naturelles (aspects économiques)

• Mahadevan, Radhakrishnan
  Université de Toronto

• Papangelakis, Vladimiros
  Université de Toronto
• Savchenko, Alexei
  Université de Toronto
• Yakunin, Alexander
  Université de Toronto

Aucune organisation partenaire n’a été touvée.

The genomics revolution has provided an unprecedented opportunity to apply biotechnology for the solution of a range of practical problems including 1) efficient extraction of metals from sulfide minerals with minimal environmental impact, 2) identification and characterization of novel enzymes that are relevant to biorefineries, 3) design of biocatalyst for the production of chemicals and 4) recombinant protein production and characterization. All of these activities require the parallel cultivation of bacteria under controlled conditions. In this proposal, we request funds to buy a high-throughput bioreactor system that will allow the evaluation of microbial metabolism under controlled conditions in multiple environments and will significantly accelerate the application of biotechnology for engineering novel bioprocesses for bioleaching (extraction of metals), biochemicals and protein production.