The application of multifunctional nanomaterials in Alzheimer’s disease: A potential theranostics strategy

Biomedicine & Pharmacotherapy, Vol. 137 (2021)

Mots clés
Auteurs
  • Yilan Xu
  • Neurodegeneration and Neuroregeneration Laboratory, Department of Basic Medicine, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang, China
  • Manna Zhao
  • Neurodegeneration and Neuroregeneration Laboratory, Department of Basic Medicine, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang, China
  • Dongming Zhou
  • Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China
  • Tingting Zheng
  • Department of Neurology, The First Affiliated Hospital of ZheJiang Chinese Medical University, Zhejiang Provincial Hospital of TCM, Hangzhou 310058, Zhejiang, China
  • Heng Zhang
  • Neurodegeneration and Neuroregeneration Laboratory, Department of Basic Medicine, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang, China; Corresponding author.

Résumé

By virtue of their small size, nanomaterials can cross the blood-brain barrier and, when modified to target specific cells or regions, can achieve high bioavailability at the intended site of action. Modified nanomaterials are therefore promising agents for the diagnosis and treatment of neurodegenerative diseases such as Alzheimer’s disease (AD). Here we review the roles and mechanisms of action of nanomaterials in AD. First, we discuss the general characteristics of nanomaterials and their application to nanomedicine. Then, we summarize recent studies on the diagnosis and treatment of AD using modified nanomaterials. These studies indicate that using nanomaterials is a potential strategy for AD treatment by slowing the progression of AD through enhanced therapeutic effects.

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