Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

International Journal of Molecular Sciences, Vol. 22 (2021)

Mots clés
Auteurs
  • Fani Ziouti
  • Department of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany
  • Maximilian Rummler
  • Research Centre, Shriners Hospital for Children-Canada, Montreal, H4A 0A9 QC, Canada
  • Beatrice Steyn
  • Research Centre, Shriners Hospital for Children-Canada, Montreal, H4A 0A9 QC, Canada
  • Tobias Thiele
  • Julius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
  • Anne Seliger
  • Julius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
  • Georg N. Duda
  • Julius Wolff Institute and Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany
  • Bjarne Bogen
  • Institute of Clinical Medicine, University of Oslo and Department of Immunology, Oslo University Hospital, 0424 Oslo, Norway
  • Bettina M. Willie
  • Research Centre, Shriners Hospital for Children-Canada, Montreal, H4A 0A9 QC, Canada
  • Franziska Jundt
  • Department of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany

Résumé

Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton’s tyrosine kinase inhibitor CC-292 (Spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microCT and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.

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