Maturational trajectories of pericortical contrast in typical brain development

NeuroImage, Vol. 235 (2021)

Mots clés
Auteurs
  • Stefan Drakulich
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada
  • Anne-Charlotte Thiffault
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada
  • Emily Olafson
  • Douglas Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada
  • Olivier Parent
  • Douglas Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada
  • Aurelie Labbe
  • HEC Montréal, 3000, chemin de la Côte-Sainte-Catherine, Montreal, QC H3T 2A7, Canada
  • Matthew D. Albaugh
  • Department of Psychiatry, Larnier College of Medicine, University of Vermont, United States
  • Budhachandra Khundrakpam
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada
  • Simon Ducharme
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada
  • Alan Evans
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada
  • Mallar M. Chakravarty
  • Douglas Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada; Corresponding author.
  • Sherif Karama
  • Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada; Douglas Institute, McGill University, 6875 Boulevard LaSalle, Verdun, QC H4H 1R3, Canada; Corresponding author at: Montreal Neurological Institute, McGill University, 3801 Rue University, Montréal, QC H3A 2B4, Canada

Résumé

In the last few years, a significant amount of work has aimed to characterize maturational trajectories of cortical development. The role of pericortical microstructure putatively characterized as the gray-white matter contrast (GWC) at the pericortical gray-white matter boundary and its relationship to more traditional morphological measures of cortical morphometry has emerged as a means to examine finer grained neuroanatomical underpinnings of cortical changes. In this work, we characterize the GWC developmental trajectories in a representative sample (n = 394) of children and adolescents (~4 to ~22 years of age), with repeated scans (1–3 scans per subject, total scans n = 819). We tested whether linear, quadratic, or cubic trajectories of contrast development best described changes in GWC. A best-fit model was identified vertex-wise across the whole cortex via the Akaike Information Criterion (AIC). GWC across nearly the whole brain was found to significantly change with age. Cubic trajectories were likeliest for 63% of vertices, quadratic trajectories were likeliest for 20% of vertices, and linear trajectories were likeliest for 16% of vertices. A main effect of sex was observed in some regions, where males had a higher GWC than females. However, no sex by age interactions were found on GWC. In summary, our results suggest a progressive decrease in GWC at the pericortical boundary throughout childhood and adolescence. This work contributes to efforts seeking to characterize typical, healthy brain development and, by extension, can help elucidate aberrant developmental trajectories.

Read more: fulltext