Federal Ministry of Education and Research

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Projets de recherche récents

Media Coverage of Psychiatric Neurosurgery: Cross-national Investigations of Public Reactions and Attitudes

2015/16-2018/19 • $225,000
Mass media circulates arguments and images that widely shape perceptions and attitudes of the public and policy-makers about biotechnology and new medical procedures. While media reports can fuel unguarded optimism for the applications to human health and well-being of neuroscience research,...

Key Determinants of Synaptic Excitation/Inhibition Imbalance in Autism Spectrum Disorders

2015/16-2018/19 • $225,000
Information processing in the brain critically depends on a balance between excitatory and inhibitory synaptic transmission (E/I balance), and E/I imbalances are observed in multiple neurodevelopmental disorders, including autism spectrum disorders (ASDs) and schizophrenia. While the molecular...

Intelligent Neuro-TEchnologies Restoring Functions of Action and Communication: an Evaluation Study

2015/16-2018/19 • $112,500
INTERFACES is an international research project on ethical, legal and social aspects (ELSA) of brain-computer interfaces (BCI). This neurotechnology has recently made ground-breaking progress and is about to enter real-world application in motor & communication assistance, neuropsychiatric...

Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis.

2014/15-2017/18 • $499,998
Increasing evidence suggests that mitochondria, a part of the cell which generates energy, are damaged in neurodegenerative diseases including PD and AD. How this dysfunction contributes to brain cell loss is unclear. Our current proposal will determine common mechanisms by which mitochondrial...

The PrPC / PDK1 / TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases

2014/15-2017/18 • $499,997
The aims of the consortium are to decipher the molecular and cellular mechanisms of neurodegeneration induced by diverse aggregate-prone proteins found in AD, prion diseases, PD, ALS, FTD and SCA-1 in order to identify susceptibility factors and therapeutic targets.

Identification of genes that modulate the severity of neurodegenerative diseases

2014/15-2017/18 • $475,000
Most forms of neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease cannot be linked to single gene mutations, i.e., they are polygentic in nature. Here we try to identify genes that when mutated commonly increase the risk to get any neurodegenerative disease.

Mechanisms of Lymphocytes Transmigration Across the Blood Brain Barrier

2014/15-2017/18 • $112,500
Many diseases of the central nervous system (CNS) show strong involvement of cells of the immune system, and are therefore considered inflammatory diseases of the CNS. Among these diseases are included multiple sclerosis (MS), Alzheimer's disease (AD) and even stroke, where immune cells invade...

Transition from acute to chronic neuroinflammation

2014/15-2017/18 • $104,235
Neuroinflammation is how the immune system of the brain fights against diseases. As a natural defense mechanism, this reaction may harbor beneficial effects, but under circumstances not yet well understood, it may also have detrimental consequences for the brain and even contribute to the...

The role of TAO2 in brain connectivity and Autism Spectrum Disorders

2013/14-2016/17 • $225,000
Autism spectrum disorders (ASDs) are neurodevelopmental disorders in which individuals have disrupted social communication and repetitive stereotyped behaviors, which lead to life-long difficulties. Approximately 1 percent of individuals in Asia, North America and in Europe have an ASD, which...

Role of genetic polymorphisms in drug metabolizing cytochrome P450 enzymes expressed in the brain for affective disorders

2013/14-2016/17 • $224,880
Cytochrome P450 (CYP) enzymes are an important class of drug metabolising enzymes, proteins that help eliminating external substances such as drugs or toxins that have been ingested or absorbed by the organism as well substances that are produced by the organism itself (endo¬genous substrates)....

VGLUT3 and vulnerability to addiction

2013/14-2016/17 • $202,958
Addiction leads to substantial human suffering as well as to tremendous economical costs for our society. A secret to the understanding of this pathology lies in unraveling the function of a specific brain region named nucleus accumbens (NAc). The NAc regulates several behavioral outputs that...

Biomaterials scaffolding for brain reconstruction in stroke

2011/12-2014/15 • $225,000
This project aims to develop innovative technologies using biomaterials applied to brain repair and regeneration for recovery of functions after stroke in animal models. The specific objectives are: 1. To build bio hybrids made of biocompatible materials, cell and chemical factors able to work...

Spreading Depolarization in Small Vessel Disease

2011/12-2014/15 • $225,000
There are presently no neuroprotective drugs with efficacy to improve outcomes after lacunar stroke. Fundamental challenges to advancing treatment of lacunar stroke are its heterogeneity in terms of cause, pathology, and the lack of mechanistic endpoints in clinical studies. Mechanistic...

Translational neuroimaging in alcoholism: identification of altered brain connectivity and treatment efficacy predictors

2010/11-2013/14 • $201,916
Alcoholism is a common pschiatric disorder with largely unmet treatment needs. Excellent animal models for this disorder have put forward a number of promising molecular targets for medication development. Yet, clinical trials aimed at exploiting this potential often fall short of expectations....

Describing pathophysiology to promote focal therapy in treatment of schizophrenia - an animal experimental study

2010/11-2013/14 • $143,289
Schizophrenia is characterized by profound disruptions in cognition and emotion. Despite pharmaco-therapeutic progresses, a considerable percentage of patients has no or only partial response to treatment. Development of more efficacious treatments is indispensible but crucially depends on an...

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