Fonds de recherche du Québec - Santé

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Projets de recherche récents

Canadian Donation and Transplantation Research Program (CDTRP): Maximizing benefits through national infrastructure and sustainability planning

2018/19-2020/21 • $2,366,774
Transplantation is used much more broadly to treat diseases than most Canadians realize. No longer is it restricted to people with organ failure. Instead, it is poised to become the preferred treatment for many chronic diseases and blood cancers. Nonetheless, challenges remain, such as the 50%...

Case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs: implementation and realist evaluations

2017/18-2020/21 • $838,575
A common reason for frequent use of health care services is the complex health care needs of individuals suffering from multiple chronic conditions, often together with mental health comorbidities and/or social vulnerability. Individuals with such complex health care needs require a variety of...

SPIDER-NET, A Structured Process Informed by Data, Evidence and Research-Network: An approach to support primary care practices in optimizing the management of patients with complex needs

2017/18-2020/21 • $838,561
Health care costs are increasing quickly. About half is spent on a small number of people with complex health problems. We need to address this. Built on a successful model for improving care by working together, the Structured Process Informed by Data, Evidence and Research (SPIDER) contains 3...

ACHRU Community Partnership Program for Diabetes Self-Management for Older Adults - Canada

2017/18-2020/21 • $812,497
Living with diabetes and other chronic (ongoing) conditions is common in older adults. These individuals have poorer health and higher use of health services compared to older adults with diabetes alone. Programs that help older adults self-manage their diabetes and other health conditions...

Implementing Mental Health Recovery Guidelines Into Services: A Pan Canadian Study

2017/18-2020/21 • $413,906
Implementing Mental Health Recovery Guidelines Into Services: A Pan-Canadian Study (Piat, Briand, Mantler Albert, Doiron, Maillet, et al)Issue to be addressed: The aim of this project is to facilitate system transformation to a mental health recovery perspective by implementing and evaluating...

Mentoring new patient-oriented researchers in innovative HIV e-care

2016/17-2020/21 • $381,898
HIV medications are getting better but for many HIV-infected Canadians taking their lifelong medication is a serious challenge. Current HIV care insufficiently addresses this. Better consideration of the patient's perspective during medical visits could help. Dr. Lebouche's research program...

euCanSHare: An EU-Canada joint infrastructure for next-generation multi-Study Heart research

2018/19-2020/21 • $358,091
Personalised medicine approaches are highly needed in the domain of cardiology, as cardiovascular diseases (CVDs) are the major contributors to mortality and morbidity worldwide. To date, cardiovascular research has been conducted by interrogating biomedical data in single cohorts, but these are...

EUCAN-Connect: A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

2018/19-2020/21 • $358,091
Rapid progress in information and biotechnologies offers the promise of better, personalized health strategies using rich phenotypic, environmental and molecular (omics) profiles of every individual. To capitalize on this great promise, the key challenge is to relate these profiles to health and...

Endoplasmic Reticulum Proteostasis to rescue Alpha1 AntiTrypsin Deficiency (acronym ERAAT) This is a proposal to the -Rare Joint Transnational Call for Proposals 2017 "Transnational Research Projects for Innovative Therapeutic Approaches for Rare Diseases"

2017/18-2020/21 • $232,178
Alpha1-antitrypsin deficiency (ATD) is a rare disease caused by mutations in the alpha1-antitrypsin (A1AT) genes leading to improperly folded protein products unable to be secreted, and that in some instances aggregate in hepatocyte endoplasmic reticulum (ER). The normal function of A1AT is to...

Addiction in the brain: Ethically Sound Implementation in Governance

2017/18-2020/21 • $216,868
This application responds to the call for European Research Projects on Ethical, Legal, and Social Aspects (ELSA) of Neuroscience by proposing a multi-site investigation to investigate and elaborate ethical considerations in the application of neuroscience-based methods for addiction diagnosis...

Personalization of Long term Treatment in Bipolar Disorder

2018/19-2020/21 • $202,161
We propose a set of studies to improve the selection of long term treatment for bipolar disorder. Bipolar disorder is a severe psychiatric condition characterized by periods of mania and depression as well as by changes in brain structure and function. People with bipolar disorder have high...

Identifying Markers of AntiDepressant response: Advancing Precision Treatment of depression

2018/19-2020/21 • $202,109
We propose to study major depressive disorder (MDD), a highly prevalent disease that is associated with major socioeconomic burden. Although it is clear that MDD results from dysfunction of the brain, and over the last decades we have obtained important leads about potential brain structures and...

Patient stratification based on DNA repair functionality for cancer precision medicine

2019/20-2020/21 • $191,110
Resistance to targeted therapies in an already enriched population is common. Consequently, a proportion of patients receive personalised cancer-treatments that are not effective and the disease progresses to a more advanced stage. Our main goal is to improve the selection of patients who are...

INTEGRative multi-OMICs approaches on iPSC-derived 2D and 3D models to elucidate the role of immune and energy metabolism related genes/pathways in Amyotrophic Lateral Sclerosis

2018/19-2020/21 • $166,605
ALS is the most common motor neuron disease. It is characterized by the death of motor neurons (MNs) in the brain and spinal cord. The disease starts in adult life and causes a progressive paralysis that is typically fatal within a few years, usually due to respiratory failure. The number of ALS...

Multilevel analyses of retinoic acid signaling to understand and treat a rare form of progressive motor impairment. (RAinRARE project)

2018/19-2020/21 • $136,465
The main aim of this project is to gain a better understanding of the mechanisms underlying a rare form of progressive motor impairment, called dystonia, associated with mutations in the RARb gene. This gene codes for a regulator of gene expression that is activated upon binding to retinoic...

Scaling-up eConsult in Primary Health Care: a policy analysis in four Canadian provinces

2018/19-2020/21 • $131,439
One of the most promising innovations that have been piloted to improve access to care is eConsult. eConsult is a model of asynchronous communication that allows family physicians (or nurse practitioners) to electronically consult specialists regarding their patients' medical issues. This model...

Promoting Indigenous health equity and culturally safe health care through decolonizing nursing education and practice

2019/20-2020/21 • $102,700
Health inequities still persist for Indigenous Peoples in Canada. One of the root causes of these inequities is systemic racism, resulting from ongoing effects of Canada's long history of colonialism. Ongoing colonial beliefs about and attitudes towards Indigenous people influence the ways in...

For Improving diagnostics and grasping the disease mechanisms of rare hypomagnesemia in patients with CNNM2 mutations

2019/20-2020/21 • $101,572
Low blood magnesium (hypomagnesemia) is a common electrolyte disorder that causes fatigue, muscle cramps, and arrhythmias. The CNNM2 gene encodes a protein that is responsible for the transport of magnesium in the kidney, the primary organ responsible for maintaining magnesium balance through...

PROSPAX: an integrated multimodal progression chart in spastic ataxias

2019/20-2020/21 • $100,081
Spastic ataxias (SPAX) present an expanding group of >100 rare degenerative diseases with joined damage of cerebellum and corticospinal tract (CST). While rapid genetic stratification facilitates current development of molecular therapies, effective trial-planning for SPAX is hampered by a lack...

Develop a multi-disciplinary approach for the personalized prenatal diagnostic and antepartum feto-maternal risk evaluation for twin pregnancies.

2019/20-2020/21 • $92,738
The frequency of twin pregnancies has risen globally due to increased use of assisted conception and increasing maternal age. Twin pregnancies have 5-9 times higher frequencies of fetal chromosomal and structural abnormalities, often deliver preterm, and have high prevalence of gestational...

A novel paradigm for effective and safer treatment of schizophrenia: biased (ant)agonists with a characterized polypharmacological profile

2018/19-2020/21 • $82,643
Schizophrenia (SZ) is a severe disease affecting 1-2% of the population. Current treatment is associated to side effects such as motor coordination problems, a feeling of the mind slowing down, abnormal electrical activity in the brain, altered heart rhythm, among many others. In addition, a...

Multi-scale exploration of autoantibodies against synaptic receptors

2018/19-2020/21 • $82,643
Psychotic disorders (PDs) encompassing schizophrenia and bipolar disorders, are major health problems worldwide. Growing evidence suggest that these major psychoses have a neurodevelopmental component involving in particular synaptic imbalance mostly between glutamatergic and dopaminergic...

ADORe: TARGETING ADOLESCENT NEUROCOGNITIVE PROCESSES IN DEPRESSION TO PROMOTE INTERVENTION RESPONSE

2018/19-2020/21 • $82,643
The World Health Organization "Health for the world's adolescents" report revealed that depression is the predominant cause of illness and disability and among the top three causes of mortality for adolescent boys and girls. Recent studies point to lasting effects of adolescent onset depression,...

Understanding the pathophysiology of Keutel Syndrome: A path towards cure

2019/20-2020/21 • $64,172
Genetic defects may cause congenital disfigurements of the face which may have profound effects on the appearance of the person leading to psychological complications. More importantly, these anomalies have serious effects on vital body functions, such as feeding and breathing. Our group has...

DECODE! Decrypting Cadherin-13 function in cortico-cerebellar circuitry underlying neurodevelopmental disorders!

2018/19-2020/21 • $56,774
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficits in social skills and communication, stereotyped and repetitive behavior, and a range of alterations in cognitive function. ASD shows high heritability and comorbidity with other disorders such...

Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention

2018/19-2020/21 • $54,167
Each year 38.2% of the EU population suffers from a mental disorder. Extensive research on the biology of stress now shows that healthy development can be derailed by excessive or prolonged activation of stress response systems in the body and brain during fetal life. Such toxic stress can have...

Développement d'un processus optimisé d'évaluation des technologies innovantes en vue de leur introduction dans le système de santé et de services sociaux

2018/19-2020/21 • $48,500
Les technologies innovantes apportent avec elles de nombreux defis pour les systemes de sante et de services sociaux (SSSS) (ex : therapie genique, dispositifs medicaux connectes). Leur nouveaute et l'insuffisance -ou la qualite faible- des donnees existantes a leur sujet se traduisent par de...

Biomarkers of ANTidepressant RESponse : early indicators and novel targets

2019/20-2020/21 • $47,648
Antidepressants (AD) are for now, the best treatment we have for major depression (MDD) a severe mental disorder. AD are one of the most commonly prescribed drugs in the western hemisphere, however their trial-and error nature combined with unwanted side-effects, leave a lot to be desired. More...

Mieux comprendre les trajectoires d'utilisation des soins et services de santé afin d'en optimiser les retombées sur les parcours de santé des patients atteints de maladies neurodégénératives en fin de vie.

2019/20-2020/21 • $38,083
L'objectif de ce projet est de mener une reflexion sur les soins et services offerts aux patients atteints de maladies neurodegeneratives, comme l'Alzheimer, la maladie de Parkinson et la sclerose en plaques, au cours de leur derniere annee de vie. Pour ce faire, nous ferons un portrait de la...

Preparing the Canadian health care system to meet the needs of older adults with combined vision and hearing impairments and their caregivers

2019/20-2020/21 • $38,083
Dual Sensory Impairment (DSI), also referred to as age-related deafblindness, is the combined loss of vision and hearing that results in a condition that is more complex and disabling than hearing or vision loss alone. Older adults with DSI often present with severe communication challenges and...

Development and preclinical testing in human cell models and transgenic mice of a novel treatment for Schinzel-Giedion Syndrome

2020/21 • $18,750
Schinzel-Giedion Syndrome (SGS) is a rare disease usually leading to death in the first decade of life. SGS is caused by mutations in a gene called SETBP1, which increases the stability of the SETBP1 protein allowing it to continue carrying out its function when it might otherwise be degraded....

Designing a toolbox of paradigmatic treatments for a targeted molecular medicine approach to autosomal-recessive ataxias

2020/21 • $18,750
Autosomal-recessive cerebellar ataxia (ARCA) is a heterogeneous group of rare neurodegenerative genetic diseases that share the common hallmark of progressive damage to parts of the nervous system that coordinate movement, such as the cerebellum. Despite its devastating consequences in daily...

Analyse des pratiques infirmières en gestion des besoins complexes en contexte de soins de première ligne

2019/20-2020/21 • $17,500
Un aspect important des soins de premiere ligne concerne la gestion des populations qui presentent des besoins complexes, notamment celles qui presentent plusieurs maladies chroniques et une prise concomitante de medicaments. Des strategies d'amelioration des pratiques fondees sur une demarche...

Optimizing the Ageing Brain? Situating Ethical Aspects of Dementia Prevention (BEAD)

2020/21 • $5,790
Background: Dementia (the most common form is Alzheimer's disease) has for a long time been conceived of as an unpreventable process of mental deterioration. Now, however, researchers claim that one out of three dementia cases can be prevented if at least nine risk factors are man-aged. These...

Determinants of metabolic recovery following bariatric surgery in individuals with type 2 diabetes mellitus

2014/15-2019/20 • $1,235,052
For most severely obese patients, bariatric surgery is more effective than medical treatment or lifestyle modification to induce long-term weight loss with durable remission of metabolic diseases. Various types of surgical operations are available. These surgeries promote weight loss through two...

The Family Navigator: A global partnership to expand access to care for autism and related conditions

2016/17-2019/20 • $400,000
Advances in brain science point to multiple risk factors for many childhood developmental disorders. These disorders have major impact both on children affected and on family well-being. Caregivers experience considerable stress and reduced self-efficacy through their child’s condition. They...

Long Term Worries: Testing New Policy Options for Financing Long Term Care

2016/17-2019/20 • $400,000
Canada’s aging population is putting pressure on our out-dated health care system. The realities of population aging mean our system must evolve to be a long-term care (LTC) system. It needs to shift its focus from hospitals and physicians towards a far greater reliance on community care, home...

La fonction de psychiatre-répondant et les soins partagés: implantation, pratiques et impacts

2016/17-2019/20 • $400,000
Question. La detection et le traitement des troubles mentaux par les omnipraticiens ne sont pas optimaux, justifiant le deploiement de soins partages pour consolider l’expertise en sante mentale (SM) de 1e ligne. La fonction de psychiatre-repondant (F-PR), impliquant un soutien des PR aux...

Impacts des cours prénataux de groupe et en ligne : vers une optimisation des services

2016/17-2019/20 • $400,000
L’education prenatale est au c(latin small ligature oe)ur de l’offre des soins et services perinataux dispenses par les etablissements integres de sante et de services sociaux regionaux et leurs partenaires des milieux communautaires. La prestation de cours prenataux de groupe (CPG) en...

REALS: Testing the safety of repurposed Enoxacin for the treatment of Amyotrophic Lateral Sclerosis

2016/17-2019/20 • $256,250
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a rare progressive and ultimately fatal degenerative disease, affecting both upper and lower motor neurons in the brain and spinal cord. ALS is characterized by a progressive loss of voluntary motor activity, including...

Seeing-Moving-Playing: Early Rehabilitation utilizing visual and vestibular technology following traumatic brain injury (SiMPly Rehab Study)

2016/17-2019/20 • $112,500
Traumatic brain injuries (TBI) are among the most commonly occurring injuries internationally. Dizziness and difficulty with balance and vision may occur following a TBI. Many people recovery in the initial weeks following injury but in some cases symptoms and difficulty functioning continues...

Repurposing acute therapies for enhanced recovery after spinal cord injury

2016/17-2019/20 • $112,500
Profound sensorimotor deficits are the hallmark of damage in the central nervous system (CNS). Among the more difficult to manage are muscle paralysis and neuropathic pain. The combination of these deficits is particularly cruel: burning or dysthesia in areas of the body that are otherwise numb...

Implementing and evaluating the scalability of COMPAS-SM: a patient-oriented quality improvement intervention targeting mental health care in primary care

2017/18-2019/20 • $48,500
I will be conducting my fellowship within the Institut national d'excellence en sante et en services sociaux (INESSS), which that promotes clinical excellence and efficient use of resources in health and social services in Quebec and supports evidence-informed policy within the Ministry of...

Performance et équité dans le continuum de santé, soins et services périnataux

2017/18-2019/20 • $48,500
Dans le contexte quebecois de la reorganisation du reseau de la sante et des services sociaux, le Centre integre de sante et de services sociaux de Chaudiere-Appalaches (CISSS-CA) fait face a des defis cruciaux en ce qui a trait aux services perinataux sur son territoire. Afin de repondre aux...

Innovative Models Promoting Access and Coverage Team (IMPACT): Supporting the Implementation of Organisational Innovations in Community-Based Primary Health Care to Improve Population Coverage and Access for Vulnerable Groups

2013/14-2018/19 • $2,188,602
Canada and Australia are two countries trying to improve their systems for delivering primary healthcare (PHC). However many consumers are still unable to access quality care - especially for the sick, the poor, or those who are otherwise disadvantaged. Poor PHC access leads to overloaded...

Integrative Epigenomics of Obesity and Metabolic Complications - The Obesity Epigenomics Trilateral Project

2016/17-2018/19 • $429,000
Obesity is a leading cause of death worldwide affecting over 500 million individuals' worldwide, figures that have nearly doubled since 1980. While the disease is an important risk factor for the development of type 2 diabetes (T2D) we still do not know why not all obese patients develop T2D....

REsolving Systems Epigenomes of T-cells in Autoimmune and Inflammatory Diseases

2016/17-2018/19 • $388,170
The recent surge in asthma (A) and Type 1 diabetes (T1D) incidence is often attributed to changes in environmental exposures, notably early infections. GWAS has revealed tens of loci where associated variants lie in non-coding, regulatory DNA regions active in CD4+ T-cells. The importance of...

Comprehensive Study of Small Noncoding RNA in Depression

2016/17-2018/19 • $386,399
We propose to study major depressive disorder (MDD), a highly prevalent disease that is associated with major socio-economic burden. Although it is clear that MDD results from dysfunction of the brain, and over the last decades we have obtained important leads about potential brain structures...

Improving care for cohesinopathies: from heart phenotypes to novel therapies

2016/17-2018/19 • $325,002
When cells in the body grow and take decisions such as how fast they divide or which fate they choose for their development, they need to read and interpret the genetic code. This process is facilitated by proteins that are called the cohesin complex. When these proteins are mutated, several...

Translating Peroxisome Biogenesis Disorders: Identifying Pharmacological Therapies and Clinical Trial Endpoints (PERescue)

2016/17-2018/19 • $324,810
Peroxisome biogenesis disorders (PBD) are rare autosomal recessive disorders caused by defects in any one of 14 PEX genes, whose protein products are required for peroxisome assembly. Defective peroxisome assembly results in multiple peroxisomal enzyme deficiencies and multi-organ failure over...

Induced pluripotent stem cells for identification of novel drug combinations targeting cystic fibrosis lung and liver disease

2016/17-2018/19 • $219,999
Although the lifespan of people with cystic fibrosis has been extended considerably over the past few years, the improvements have largely come from better treatment of the symptoms and not the underlying cause of the disease. Effective drugs for treating CF based on actually targeting the...

Intelligent Neuro-TEchnologies Restoring Functions of Action and Communication: an Evaluation Study

2015/16-2018/19 • $112,500
INTERFACES is an international research project on ethical, legal and social aspects (ELSA) of brain-computer interfaces (BCI). This neurotechnology has recently made ground-breaking progress and is about to enter real-world application in motor & communication assistance, neuropsychiatric...

Pratiques réflexives pour une meilleure utilisation des opioïdes dans le traitement des lombalgies

2017/18-2018/19 • $25,292
Les lombalgies sont la principale cause d'annees vecues avec incapacite a travers le monde et constituent l'une des raisons les plus courantes pour la recherche de soins de sante. Cette problematique represente le diagnostic le plus courant pour lequel les medecins prescrivent des opioides....

The Canadian National Transplant Research Program: Increasing Donation and Improving Transplantation Outcomes

2013/14-2017/18 • $11,250,000
Organ and bone marrow transplants are well-established treatments for patients with incurable medical conditions. However, major gaps and obstacles prevent transplantation from being fully effective. We need to develop new knowledge, policies and health care practices to overcome these barriers....

Full Resolution Metabolic Disease Epigenomics in Human Populations

2013/14-2017/18 • $1,249,500
Obesity and diabetes are diseases of increasing importance in Western societies and beyond. The increase in their occurrence in Canada and elsewhere along with clustering of these diseases in families suggests that both environment and genes play a role. In past years the genes have been...

Role of epigenetic modulation in breast cancer etiology and drug resistance

2013/14-2017/18 • $770,000
The major objective of this proposal is to evaluate the contribution of a gene known as EZH2 in breast cancer progression. Using a number of well-defined mouse models we will assess whether elevated expression of EZH2 in breast cancer cells confers resistance to many of the drugs currently used...

Generating innovation through the use of common data: Improving the diagnosis and treatment of pediatric and adolescent mild traumatic brain injury in Canada.

2012/13-2017/18 • $766,895
The incidence of pediatric traumatic brain injury (TBI) in North America is alarmingly high; studies suggest that mild TBI (mTBI) make up 70-80% of all cases reported. Of particular concern is that not only do many post-concussive symptoms, which manifest as cognitive, physical and behavioural...

The Evaluating Health Adaptation to Climate Change (EvHACC) research program

2014/15-2017/18 • $460,254
Climate change has been described as the greatest threat to public health this century, with Indigenous populations identified as 'highly vulnerable'. The global response to the risks posed has been to focus on reducing greenhouse gas emissions. This is imperative yet the science shows that we...

V1sages 2 - Partenaires pour une organisation optimale du continuum de soins des grands utilisateurs de services de santé et de services sociaux

2014/15-2017/18 • $400,000
Il s'agit d'un projet issu d'un partenariat entre une equipe de chercheurs et de decideurs (Ministere de la sante et des services sociaux du Quebec, Agence de la sante du Saguenay-Lac-St-Jean et centres de sante et de services sociaux de Chicoutimi, Jonquiere, Alma et La Baie) et un partenaire...

A Prospective, Longitudinal Study of Medical Service Usage comparing Boys and Girls with and without Conduct Problems

2014/15-2017/18 • $399,126
While the link between childhood conduct problems and increased medical service usage in adulthood has been established in the literature, there is little knowledge on the mechanisms that could explain this association. It is unclear whether differences in medical service usage between adults...

Évaluation des effets de la pratique de l'évaluation d'impact sur la santé (EIS) en Montérégie.

2014/15-2017/18 • $198,947
La pratique EIS, au niveau provincial, est une priorite du MSSS du Quebec. Elle represente un moyen privilegie pour appliquer concretement l'article 54 de la Loi sur la sante publique puisqu'elle permet de responsabiliser et d'impliquer differents secteurs d'activite a travailler ensemble pour...

Mechanisms of Lymphocytes Transmigration Across the Blood Brain Barrier

2014/15-2017/18 • $112,500
Many diseases of the central nervous system (CNS) show strong involvement of cells of the immune system, and are therefore considered inflammatory diseases of the CNS. Among these diseases are included multiple sclerosis (MS), Alzheimer's disease (AD) and even stroke, where immune cells invade...

Transition from acute to chronic neuroinflammation

2014/15-2017/18 • $104,235
Neuroinflammation is how the immune system of the brain fights against diseases. As a natural defense mechanism, this reaction may harbor beneficial effects, but under circumstances not yet well understood, it may also have detrimental consequences for the brain and even contribute to the...

CLC chloride channels and Megalencephalic leukoencephalopathy: molecular mechanisms and therapeutics

2013/14-2016/17 • $325,000
Glial cells play a central role in brain water and ion homeostasis and the maintenance of low extracellular potassium during neuron cell activity. These functions are impaired in a rare type of leukodystrophy called MLC (megalencephalic leukoencephalopathy with subcortical cysts). Mutations in...

Idiopathic Infantile Hypercalcemia: European-Canadian Consortium

2013/14-2016/17 • $271,064
Idiopathic infantile hypercalcemia (IIH) is a rare genetic condition characterized by hypercalcemia and nephrocalcinosis with unknown long-term implications and limited therapies. The cause was unknown until recently when a team including Jones/Schlingmann on this grant proposal showed that the...

Retinitis Pigmentosa diagnosis and therapy: retinal remodeling and optogenetic reactivation of degenerated retina

2013/14-2016/17 • $259,441
Retinitis pigmentosa (RP) is a hereditary rare disease of the retina leading to incurable blindness. When most photoreceptors degenerate and lose their ability to respond to light, a substantial quantity of dormant cone photoreceptors can persist. The RP retinal tissue therefore contains these...

Novel Therapies for Cystinosis

2015/16-2016/17 • $224,998
Cystinosis is a rare genetic disease causing kidney failure in childhood and progressive deterioration of other organs later in early adulthood. Current therapies are inadequate; although disease progression is slowed, all cystinosis patients require kidney transplantation and survival past the...

OPTIMIZING CARE FOR ADULTS WITH CONGENITAL HEART DISEASE- TARGETING PATIENTS AT HIGH RISK FOR HEART FAILURE HOSPITALIZATION

2015/16-2016/17 • $144,444
We showed that advances in medical and surgical therapy have led to a 57% increase in the adult congenital heart disease (ACHD) population over the last decade. By 2010, an estimated 250,000 Canadians had congenital heart disease (CHD) of which ~70% were adults. We have also shown that ACHD...

Dysregulation of RNA in the pathogenesis of ALS

2013/14-2016/17 • $100,000
Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disease) is a fatal neurodegenerative disorder characterized by the loss of certain neurons that relay messages from the brain to skeletal muscles. The result is gradual loss of the ability to move, to swallow, to speak and eventually to breathe....

Hearing, Remembering, and Living Well: Paying Attention to Challenges that Older Adults Face in Noisy Environments

2012/13-2015/16 • $222,893
It has become increasingly clear that the difficulties that older adults have in understanding what people are saying limit their access to public spaces and interfere with their ability to socialize. Clearly, the inability of older adults to understand what is being said in the noisy situations...

Continence across continents to upend stigma and dependency

2012/13-2015/16 • $219,607
details in main application

Understanding the Role of Contrasting Urban Contexts in Healthy Aging: An International Study of Daily Mobility and Active Living Using Wearable Sensor Devices across Cohorts

2012/13-2015/16 • $115,733
!see proposal for entire abstract! Background: Research has shown that key factors of healthy aging such as level of physical activity, social participation or mobility can vary depending on where older adults live. Yet we still fail to understand how environments influence healthy aging. In a...

Subvention de formation des IRSC-FRSQ en médecine génétique appliquée

2010/11-2014/15 • $1,192,623
Dans le contexte des Initiatives strategiques pour la formation en recherche dans le domaine de la sante, le Reseau de medecine genetique appliquee (RMGA) du Fonds de la recherche en sante du Quebec (FRSQ) souhaite elargir le panel des activites offertes dans le cadre de son programme de...

CIHR - Quebec Training Network in Perinatal Research

2010/11-2014/15 • $832,500
The exponential expansion of knowledge in the basic and clinical sciences in perinatology requires that health professionals and researchers develop new expertise to integrate the biological, social, cultural and ethical issues of new reproductive technologies in their research. Moreover,...

The CIHR/FRSQ Training Program in Cancer Research at McGill

2010/11-2014/15 • $827,885
The McGill Integrated Cancer Research Training Program (MICRTP) seeks to support the development of future scientific leaders with the mission of developing and maintaining a diverse educational program that stimulates and supports basic and clinical research training thus encouraging the...

Vers l'amélioration des services et des soins palliatifs de fin de vie : Adapter et implanter des programmes de soutien en milieu de travail et évaluer leur effet sur la SATisfaction, le sens au travail et le bien-être des INfirmières -SATIN II

2012/13-2014/15 • $348,297
Avec le vieillissement de la population, les Canadiens reclament un meilleur acces a des soins palliatifs (SP) de qualite et les services dans ce secteur de soins demeurent a organiser. L'organisation de tels services necessite la formation et le soutien aux soignants. Les soins de fin de vie...

Les laboratoires de promotion de la santé comme outil de développement professionnel et organisationnel en santé publique : étude de cas

2012/13-2014/15 • $345,813
De nouveaux modes d'organisation des services de sante et les developpements contemporains en terme de concepts et methodes en sante publique amenent le besoin de renouveler les pratiques des professionnels evoluant dans ce secteur. De nombreux efforts sont en cours afin d'ajuster l'offre de...

Partnership for applied research in fracture prevention programs for the elderly

2012/13-2014/15 • $340,499
During their lifetime, approximately 50% of Canadian women and 30% of Canadian men will experience at least one fracture due to bone fragility (FF). Evidence is growing regarding prevention programs' effectiveness to prevent falls, but prevention of fractures through fall prevention programs has...

Étude Québécoise d'Intervention pour les Parents d'Enfants d'âge préscolaire avec des problèmes de comportements (ÉQUIPE)

2012/13-2014/15 • $294,473
Les problemes de comportements (ex: agressivite, hyperactivite) chez les jeunes enfants, sont le principal motif de consultation en sante mentale. Ces problemes sont frequents et perturbent le developpement de l'enfant et sa famille. Sans traitement, les problemes persistent a l'adolescence et...

Vers un continuum de services pour l'AVC, Evaluation des structures, processus et indicateurs de rendement des services de réadaptation

2012/13-2014/15 • $245,777
L'accident vasculaire cerebral (AVC) cause des incapacites dans differents domaines d'activites et souvent une diminution de la qualite de vie. Au Quebec, plus de 12,000 personnes subissent un AVC chaque annee. Ce nombre s'eleve a 50,000 individus au Canada ce qui entraine d'importants couts de...

Equity in Care: Measuring the Impact of Quebec's Childcare Policies on Health and Health Equity

2014/15 • $100,000
Quebec's approach to child support policies has been unique among Canadian provinces and territories in providing universal public daycare and in instituting a parental insurance plan more flexible and generous than those to be found in other Canadian jurisdictions. However, there has been very...

Évaluation d'impact sur la santé de modifications du programme d'aide sociale du Québec

2014/15 • $81,124
Depuis les annees 1980, les etudes des liens entre pauvrete et mauvaise sante se multiplient et degagent un portrait clair au point ou, en 2008, la directrice de l'Organisation mondiale de la sante affirmait que « les inegalites sociales tuent a grande echelle ». Si les effets sont indeniables,...

The integrated Research Network on Perinatology

2010/11-2013/14 • $5,998,025
There are important knowledge gaps concerning the long-term impact of various adverse prenatal risk factors (social, behavioral, environmental and genetic) on the health of future generations. This is in part due to the lack of prospective clinical research on large cohorts, transcending...

Les composants non-amyloïdes dans la maladie d'Alzheimer: le cholestérol.

2010/11-2013/14 • $502,800
The amyloid cascade hypothesis in AD has fulfilled its aim in fostering research but appears to be now insufficient to explain the mechanisms of the disease. The role of molecules interacting with Abeta peptide appears essential. Associated proteins have been thoroughly investigated. However,...

Relations moléculaires entre la maladie d'Alzheimer et les maladies à prions : une nouvelle voie dans la lutte contre les démences.

2010/11-2013/14 • $410,000
This research project is to generate critical knowledge on the molecular mechanisms underlying Alzheimer's disease and prion diseases with potential developments of new avenues in therapeutical approaches. The improvement of amplification methods for AB and the expected new specific antibodies...

Soutenir l'amélioration de la qualité des soins de première ligne pour les troubles anxieux et dépressifs: Cible Qualité II

2011/12-2013/14 • $350,000
Une personne sur cinq souffre d'anxiete ou de depression au cours d'une annee. Alors qu'il existe des psychotherapies et medications efficaces, moins de la moitie des personnes qui en souffrent obtiennent un traitement qui correspond aux meilleures pratiques. Au Quebec, les services de sante...

La transmission glutamatergique dans la maladie d'Alzheimer

2010/11-2013/14 • $341,501
Aucun sommaire

The Quebec Knowledge-1 Network: A learning community for primary and integrated care

2013/14 • $75,000
An existing Quebec primary care knowledge network will create and coordinate a new cluster dedicated to integrated care, to be overseen by an advisory committee comprised of leads from policy, clinical and research backgrounds, as well as a patient partner Lead. By involving end-users and other...

MicroARNS comme modulateurs de la pathologie Tau

2010/11-2013/14 • $60,000
Thirty five millon people worldwide are estimated to be living with Alzheimer's disease and related dementia. This number is expected to double every 20 years. Alzheimer's disease represents 70% of demented disorders. Others include Lewy body dementia, vascular dementia and tauopathies such as...

Optimisation de la qualité de vie au travail, la performance organisationnelle et le développement de milieux de travail sains par l'implantation de stratégies de promotion de la santé

2010/11-2012/13 • $350,000
Le systeme de sante au Quebec et au Canada fait face a des defis majeurs de penurie de main d'oeuvre. Au niveau Canadien, plusieurs regroupements de decideurs et travailleurs identifient l'importance de promouvoir des milieux de travail sains etant donne le lien entre la sante des travailleurs,...

Mettre en oeuvre des pratiques innovantes d'organisation du travail pour faire face à la pénurie de main d'oeuvre.

2010/11-2012/13 • $302,562
Ce projet s'interesse au processus de mise en oeuvre de projets d'organisation du travail inities par un nombre croissant d'organisations de sante en vue d'optimiser l'utilisation du personnel dans un contexte de penurie. Au Canada comme dans la plupart des pays industrialises, le systeme de...

Vivre en zone frontalière:Hybridation entre les formules de logement social et d'hébergement destinées aux personnes vulnérables au Québec

2010/11-2012/13 • $264,165
Le present projet de recherche s'interesse aux nouvelles formules residentielles qui sont a la limite entre le logement et l'hebergement. A partir d'entrevues d'acteurs gravitant autour de ces nouvelles formes residentielles hybrides, l'etude tentera de trouver des reponses aux questions des...

Assessing the evolution of primary healthcare organisations and their performance (2005-2010) in two regions of Quebec province: Montréal and Montérégie

2010/11-2012/13 • $253,245
The Canadian healthcare system is currently experiencing important transformations, particularly in its primary healthcare (PHC) sector. Most of these reforms propose implementing new models of PHC to better meet the expectations and the needs of users of services and the whole population....

Travailler avec un interprète en santé mentale. Besoins en ressources linguistiques et pratiques des professionnels de la santé mentale de la région de Montréal.

2010/11-2011/12 • $184,484
Ce projet a pour objectif d'evaluer les pratiques, ressources et besoins linguistiques des intervenants en sante mentale sur l'ile de Montreal. En effet, 3% de la population de l'ile ne parle ni le francais, ni l'anglais et pres du tiers de cette population est de langue maternelle autre que les...

Optimisation de la collaboration avec les familles et les organismes communautaires au sein des transformations en santé mentale

2010/11 • $53,812
Le Ministere de la Sante et des Services sociaux du Quebec a identifie la sante mentale comme axe prioritaire d'intervention et a developpe un plan d'action en sante mentale 2005-2010. Un de ses objectifs est de favoriser la participation des personnes utilisatrices de services et de leurs...

Assessing and improving electronic knowledge resources in partnership with information providers

2010/11 • $18,191
We propose to examine important phenomena regarding the use and management of recommendations for drug treatment, when these recommendations are retrieved by health professionals from online databases. While access to treatment recommendations from online databases is increasing, little is known...

Anne-Cecile Desfaits

PI 2 Autre 1

Serge Dulude

Autre 1

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