Nova Scotia Health Research Foundation

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Projets de recherche récents

Maritimes SPOR Support Unit

2013/14-2020/21 • $12,450,911
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Advancing Indigenous Health Nursing Research, Education and Practice by Mobilizing Indigenous Knowledge and Strengthening Partnerships

2019/20-2020/21 • $209,000
Indigenous children are the fastest growing cohort of children in Canada and Indigenous Peoples recognize their knowledge systems are the way forward to support health and healing and for the next generation to thrive. Two-Eyed Seeing is an approach that recognizes the strengths of both...

Cross Provincial Comparison of Programs for Patients with Multimorbiditiy in Interprofessional Collaborative Family Practice Teams in Primary Health

2018/19-2020/21 • $156,829
More and more Canadian adults are living with more than one chronic diseases or conditions at the same time, especially as they get older. This creates complex health and social challenges that can be helped by a team of interprofessional primary healthcare providers. We will identify and...

Long Term Worries: Testing New Policy Options for Financing Long Term Care

2016/17-2019/20 • $400,000
Canada’s aging population is putting pressure on our out-dated health care system. The realities of population aging mean our system must evolve to be a long-term care (LTC) system. It needs to shift its focus from hospitals and physicians towards a far greater reliance on community care, home...

Canadian Consortium on Neurodegeneration in Aging - Full Proposal

2014/15-2018/19 • $24,450,000
The neurodegenerative brain diseases - Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies - will be the "diseases of the 21st century" due to aging of our population. The decision by CIHR to establish a Canadian Consortium on Neurodegeneration in Aging...

Advice Seeking Networks in Residential Long Term Care

2014/15-2017/18 • $450,000
Using the latest innovations and research evidence to care for seniors living in residential long term care (nursing homes) is an important goal that is best achieved when successful innovations and practices can spread throughout the nursing home sector efficiently. However, we know little...

A prospective study of the trajectory and biopsychosocial determinants of postpartum genito-pelvic pain

2014/15-2017/18 • $113,682
During pregnancy and after childbirth, many women experience pains that can severely disrupt their lives. Pain in the genital or pelvic region ("genito-pelvic") is poorly understood, often misdiagnosed or ignored, and viewed as shameful by the women who experience it. Genito-pelvic pain is...

Partnership for a healthy workplace response to breast cancer

2016/17-2017/18 • $46,937
The number of Canadians living with and beyond cancer is growing and so, too, is the need for a healthy workplace response to this illness. National cancer agencies have called upon researchers to partner with cancer survivors and other stakeholders in the labour and cancer systems to provide...

Improving distress management knowledge and skills for oncology nurses: A Pan-Canadian knowledge translation study

2013/14-2016/17 • $599,864
By the end of 2012, 88,000 Canadian women and 97,600 men will be diagnosed with cancer. A cancer diagnosis and its treatments can lead to considerable emotional distress, including symptoms of depression, anxiety, or fatigue. It is important to attend to these symptoms as they can reduce overall...

Eukaryotic organelles, parasites and multicellularity: comparative genomic and proteomic approaches.

2013/14-2016/17 • $247,678
Understanding how complex single-celled organisms evolved into the super-kingdoms of Life over the last 2 billion years is a fundamental question in biology. We propose to use advanced genomic sequencing, microscopy, computation, cell biology and proteomics to reveal the mechanisms behind some...

Design, Synthesis and Evaluation of Prodigiosin Analogues as Chemotherapeutic Agents

2013/14-2016/17 • $172,932
We are developing new drugs for breast cancer based on a naturally occurring molecule called prodigiosin found in bacteria in our homes and workplaces. Extracts containing prodigiosin were used in the USA from 1893 to 1963 to treat various cancers. However, prodigiosin was too toxic and was...

Supporting shared decisions in pediatric otolaryngology (Phase 1): Needs assessment and decision aid development

2014/15-2016/17 • $159,816
Pediatric otolaryngology (ear, nose and throat) surgeries are the most common surgeries in children. Many pediatric otolaryngology surgeries could be considered minor, but they are not without risk and benefit is not guaranteed. Thus, surgeons and families must make complex decisions among...

An Objective Model of Joint and Muscle Function Outcome after Total Knee Arthroplasty Surgery

2014/15-2016/17 • $144,313
An estimated four million (16%) adult Canadians live with arthritis and the demand for total knee replacement surgery is increasing at a similar alarming rate, particularly among younger individuals who desire more active lifestyles. The surgery is limited in its ability to provide significant...

Do Maternal and Neonatal Factors Predict Long-term Child Health and Health Care Utilization?

2014/15-2016/17 • $89,270
Normal development of the fetus during pregnancy is important for the child's future health. Development of the fetus in turn is influenced by the mother's health before and during pregnancy. The negative influence of growth abnormalities and maternal health problems on the short-term health...

Opportunities for very early intervention in youth at high risk for severe mental illness

2012/13-2015/16 • $288,773
Severe mental illness, such as schizophrenia, bipolar disorder and major depression, tends to develop in adolescence and cause life-long disability. These diseases share many risk factors, the strongest of which is having one or both parents with mental illness. Recent accrual of knowledge on...

Understanding Discharge Instruction for Children and Caregivers in the Transition from Pediatric Emergency Care

2013/14-2015/16 • $217,902
Over 87% of children who visit Canadian emergency departments (EDs) are discharged home to their place of residence. Following discharge, many children and their caregivers are unable to list their diagnosis, recount the name and purpose of medications they received, outline the recommended post...

Lifestyle actIvity correlates For diabEtics (LIFE)

2012/13-2015/16 • $192,340
Moderate to vigorous physical activity (MVPA) has been shown to have numerous benefits in patients living with type 2 diabetes. However, in order to achieve these benefits, it is recommended that people living with type 2 diabetes accumulate at least 150 minutes of MVPA per week. Unfortunately,...

Beta-catenin as a regulator of cancer cell survival

2012/13-2015/16 • $187,395
The cells lining many human organs (epithelial cells) form a single layer. Cells that detach from this layer die. Cancer cells are often derived from epithelial cells. To be able to form three-dimensional tumors and spread throughout the body cancer cells have to be able to survive outside of...

Role of AIIt in homocysteine-mediated vascular dysfunction

2012/13-2015/16 • $185,618
A diet low in folic acid (found in leafy greens) and high in the amino acid methionine (found in many meat products), can lead to high blood levels of homocysteine (Hcy), which in turn is a risk factor for heart attack and stroke. Damage to the blood vessels that results in heart attack and...

The Role of Carboxypeptidase-D in Prostate Cancer Growth and Progression

2012/13-2015/16 • $174,874
Prostate cancer (PCa) is the most frequently diagnosed cancer among men, afflicting one in seven Canadian men in his lifetime. PCa is typically treated by surgery and radiation, and may be combined with androgen ablation therapy. The latter aims to reduce serum androgens and to inhibit the...

Role of organic anion transporters 1, 2, and 3 in antiviral drug clearance from the eye

2013/14-2015/16 • $173,646
Viral infections of the eye, such as herpes and cytomegalovirus can cause a variety of complications leading to blindness. Effective treatment of these infections is challenging since antiviral drugs administered outside of the eye have a difficult time getting in, and once in they are rapidly...

Pregnancy characteristics and maternal long term weight-related outcomes: a cohort study.

2012/13-2015/16 • $107,734
Nova Scotia is at the forefront of the obesity epidemic in Canada. Weight gain and obesity-related health conditions in women may be related to pregnancy characteristics like how much weight a woman gains during her pregnancy, conditions like pre-eclampsia or gestational diabetes, and the birth...

Birthing Relationships and Rural Health Practices: The Experiences of Queer Women and Their Perinatal Care Providers.

2013/14-2015/16 • $63,228
Queer birthing women experience social exclusion in the Canadian health system based on gender and sexual orientation. Yet little research has been conducted on the experiences of these women, even less in rural care. Homophobia, heterosexism and intolerance continue to be embedded in health...

Medication adherence as a safety issue: Generating theory from the perceptions of individuals with Cystic Fibrosis, families, and healthcare providers on the medication management process

2014/15-2015/16 • $49,755
Living with Cystic Fibrosis (CF) means taking medication all your life. We know that people in general do not take medications as prescribed and people with CF have the same problem. Not taking medications as prescribed is a safety issue and means that the diseases that people have will not be...

Emerging health researchers and the commercialization of academic science

2013/14-2015/16 • $5,755
The goal of this project is to understand the two-way relationship between emerging health researchers and commercialization practices at Canadian universities. This project will measure in several ways how commercialization practices such as patenting influence the work, interactions, and...

Intervention models for preschoolers with autistic spectrum disorder (ASD): A population-based comparative effectiveness study

2012/13-2014/15 • $399,417
More and more Canadian children are being diagnosed with autistic spectrum disorders (ASD). These disorders lead to significant differences in children's ability to interact, communicate, and play like other children, and can have a devastating impact on families. Canadian provinces have...

Sexual Health Services and Sexual Health Promotion Among Undergraduate Students in the Maritimes

2012/13-2014/15 • $326,535
Background: Sexually transmitted infections, unwanted pregnancies and other negative sexual health outcomes are well known threats to undergraduate university students' health and wellbeing. In addition, concerns about such issues as sexual assault and sexual identity, are common on university...

Design, Synthesis and Optimization of New Chemical Entities as Antimicrobial Agents

2011/12-2014/15 • $168,482
Infectious disease persists as a major medical problem. Increasingly, bacterial infections are becoming resistant to conventional antibiotics. Currently, we are facing four "plagues": "re-emerging plague" (as Gram-positive bacteria become less susceptible to conventional antibotics); "new...

Molecular interrogation and a small molecule screen of NUP98-HOXA9 induced AML in the zebrafish

2011/12-2014/15 • $168,452
Despite advances in leukemia therapy, acute myeloid leukemia (AML) continues to pose significant treatment challenges, with cure rates of less than 60% following intensive treatment. Pertinent animal models will be critical to understanding the molecular pathways underlying this disease in order...

Maternal Analgesia for Procedural Pain in Preterm Neonates: Does It Remain Efficacious?

2011/12-2014/15 • $138,157
When a mother holds her almost naked baby next to her own bare chest, known as Kangaroo Mother Care because it is similar to how kangaroo's carry their young, they both benefit. We know that this caring method decreases the pain response in hospitalized babies who must have painful needle pokes...

Managing the Social Environment: What Matters for First Line Managers

2011/12-2013/14 • $387,657
The broad span of control of first line hospital managers translates into influence. Their direct reports look to them for direction. They also look to their supervisors to explain their complex work environment. Maintaining a strong level of collegiality is a foundation for managers' influence....

Care and Construction: Assessing Differences in Nursing Home Models of Care on Resident Quality of Life

2011/12-2013/14 • $366,967
A team of researchers and nursing home representatives are working together to learn about the differences that different physical designs and staffing approaches in nursing homes may have on their resident quality of life. Across Canada, long term care providers, funded both publicly and...

Understanding reward motivation and expectancy in early phase psychosis smokers: a neuroimaging and genetic approach

2010/11-2013/14 • $201,164
Psychotic disorders, such as schizophrenia, are severe mental illnesses affecting approximately 3% of the population. These disorders typically begin in late adolescence or early adulthood and are often associated with lifelong, psychological and social impairments. Smoking rates are highly...

Regulation of nuclear membrane architecture and cell proliferation by CTP:phosphocholine cytidylyltransferase (CCT)

2010/11-2013/14 • $124,536
Cancer cells have unusual metabolism of sugars, fats and amino acids that allows then to survive and grow rapidly into tumours. This rapid metabolism of fat is proposed to allow cancer cells to make more membranes that are required for growth and cell division. One such fatty molecule that makes...

Connective Tissue Growth Factor and fibrocyte recruitment to the myocardium

2011/12-2013/14 • $79,310
Heart disease is considered to be the number one killer of Canadians. An important part of many heart diseases is a process of heart scarring also called fibrosis that occurs in response to injury. Unfortuntely, while this process is benneficial initialy it can lead to replacement of heart...

Nova Scotia SPOR Network in Primary and Integrated Health Care Innovations

2013/14 • $75,000
This grant application proposes to bring together the initial members of the Nova Scotia Strategy for Patient Oriented Research Network for Primary and Integrated Health Care Innovations (NS-PIHCI). If funded, NS-PIHCI will provide Nova Scotia the opportunity for research, policy, clinical...

Molecular and immunological characterizations of reovirus oncolysis

2013/14 • $8,778
We don't normally think of viruses as beneficial organisms because they are invariably associated with human diseases. In 1998, we demonstrated that a naturally occurring, benign human virus, called reovirus, is a potent cancer killer. This virus is able to infect a variety of cancer cells,...

Pandemic influenza: Competency-based health human resources planning for teams

2010/11-2012/13 • $399,995
The study proposes an innovative competency-based approach to employ existing health care staff during a surge such as pandemic influenza, optimizing already limited health human resources (HHR) stretched even further in surge conditions. This applied approach is based on the health needs of...

A Double Blind Randomized Controlled Trial Examining the Efficacy of Methadone in the Treatment of Chronic Neuropathic Pain

2010/11-2012/13 • $251,316
INTRODUCTION: There is an important need for inexpensive drugs that treat neuropathic pain. Early research suggests that methadone may be a good, inexpensive drug to treat neuropathic pain. Methadone is available in a low cost powder that is easily prepared for different routes of...

An active role for bipolar cells in processing synaptic signals in the retina

2010/11-2011/12 • $202,302
How diverse elements of parallel neuronal circuits interact to extract, organize and convey relevant information is a fundamental question in neurobiology. The intricate anatomical and functional organization of multiple parallel synaptic circuits in the CNS makes this investigation a daunting...

Defining the roles of the anaphylatoxins in colitis

2010/11-2011/12 • $181,708
Our bodies have several ways to defend against invading bacteria. One of the quickest defenses is the complement system, a collection of molecules already circulating in blood and tissues that become reactive when they come in contact with bacteria. Some of the complement proteins become split...

Nurses' Career Aspirations to Management Roles: Identifying the Next Generation of Nursing Leaders

2010/11-2011/12 • $124,001
This study will investigate personal and situational factors that influence direct care nurses' interests in assuming management roles within their careers, the reasons for their interest or lack of interest in assuming these roles, and learning needs relevant for preparation for these roles....

Calcium channel function in retinal ganglion cells following injury

2010/11-2011/12 • $117,627
Blindness and reduced vision due to the loss of cells, called ganglion cells, in the retina can occur in patients suffering ocular trauma. It is known that a leading cause of retinal cell death is the excessive accumulation of calcium ions within the cells. This aberrant calcium signal activates...

Safety in Homecare: A focus on medication management

2010/11-2011/12 • $110,240
Patient safety is a current national and international priority with medication safety earmarked as both a prevalent and high-risk area of concern. Medication safety requires the integrity of a complex series of interrelated steps, such that failure to adequately assess, prescribe, dispense, and...

Partnership for Ongoing Impact Assessment of Academic Detailing

2010/11-2011/12 • $93,250
'Academic detailing' programs provide independent, evidence-based information to physicians to promote best prescribing practices through one-on-one or small group visits to their offices. This strategy is being used by programs in six provinces. In brief, academic detailing programs aim to...

Investigating altered PCSK6 activity in ovarian cancer

2010/11-2011/12 • $91,139
In order for cells to function correctly many cellular proteins need to be activated by enzymes called proprotein convertases. Too little or too much enzyme can change the levels of the active protein that can lead to abnormal cellular responses. We are examining how changes in the levels of the...

Investigation of the molecular composition and mechanisms of induction of the mitochondrial permeability transition pore

2010/11-2011/12 • $57,888
The prevention of excessive cell death is a key strategy during the treatment of heart attacks and strokes. In order for this treatment to be efficient, it is essential to identify, at the molecular level, those central events which occur during pathology and are responsible for cell death. It...

Synthesis and Evaluation of Butyrylcholinesterase Ligands for Brain Imaging in Dementia

2011/12 • $53,624
Butyrylcholinesterase is an enzyme involved in the breakdown of acetylcholine, a chemical important in communication between brain cells, which is found in lesser amounts in Alzheimer's disease (AD). AD is also marked by loss of memory and the deposition of toxic proteins in the brain, forming...

Chemerin/CMKLR1: A Molecular Switch to Regulate Bone Marrow Adipogenesis and Osteoblastogenesis

2011/12 • $35,000
Osteoporosis is characterized by a loss of bone tissue that ultimately results in bone fragility and an increased risk of fracture. This disease results from an imbalance of the normal bone remodeling processes consisting of the removal of old bone and new bone formation. One factor that...

Design, Synthesis and Evaluation of Prodigiosin Analogues as Chemotherapeutic Agents

2011/12 • $35,000
We will investigate a new type of cancer treatment, based on a relatively unexplored structural scaffold of a naturally occurring molecule called prodigiosin. Prodigiosin was used in the USA from 1893 to 1963 as a (folklore) medicinal agent against various types of cancer. Under laboratory...

Endosymbiosis, parasitism, and genome evolution

2011/12 • $18,912
Microorganisms thrive in virtually every habitat imaginable. Understanding how they adapt to changing environments is a fundamental problem in biomedical research. The genetic makeup of endosymbionts -- cells that live inside other cells -- often differs significantly from free-living organisms,...

Regulation of transcription in Huntington's Disease

2010/11 • $114,362
The genetic cause of Huntington's disease was identified 15 years ago. All people who go on to develop the devastating and progressive physical, emotional and mental symptoms of Huntington's disease have one copy of the gene that encodes an important protein called huntingtin which is slightly...

Structural determinants of hepatic apolipoprotein B metabolism

2010/11 • $76,207
Lipoproteins are complexes of protein and dietary fat that are important in the distribution of food energy in the bloodstream. However, when fats are consumed in excess, they can cause the liver to produce even more lipoproteins. The liver produces a carrier protein, called apolipoprotein B,...

Mechanisms of Rehabilitation and Recovery in Visuo-Spatial Neglect

2010/11 • $67,338
Changes in attentional abilities are common after stroke and make it difficult for an individual to regain function and independence in activities of daily living. The focus of our research is on an attentional deficit called visuo-spatial neglect. Neglect makes it hard for an individual to pay...

Treatment of intestinal inflammation with piperine, a dietary phytochemical with immune-modulating activity

2010/11 • $59,438
Inflammatory bowel disease (IBD) currently afflicts about 1 in every 200 Canadians. For the most part, IBD is treated with drugs that inhibit inflammation or suppress the immune system. Unfortunately, undesirable side effects are associated with all current IBD treatments. A need therefore...

Evaluating the Impacts of Public Engagement in Health Systems: A Comparative Research-Practice Collaboration

2010/11 • $38,500
Ensuring that the most effective public engagement strategies are used in appropriate contexts within constrained budgets is a challenging undertaking that can be associated with high political risks if not carefully managed. The proposed study will address these management needs through the...

Assessing the human resource capacity necessary to care for older people with chronic home care needs in the coming decades: Who will bear the increased costs?

2010/11 • $35,000
Older Canadians who need assistance receive most of their support from informal sources, often spouses or adult children. Some also receive formal support provided by government programs, home care agencies or other paid individuals. Baby boomers soon to turn age 65 have had fewer children than...

Enhancing the quality of workplace communities: Assessing predictors and testing interventions

2010/11 • $32,268
The Research: The research questions are: 1) How can organizational interventions based on a worklife model and adapted to the participating health-care institutions create a supportive work environment and improve health-care provider health? 2) How do point-of-care health care providers makes...

Understanding the individual, organizational, and system factors influencing the integration of the nurse practitioner role in long term care settings in Canada

2010/11 • $26,922
There is a need to address the shortage of health professionals to care for seniors in long-term care (LTC) settings. Nurse practitioners (NPs) in LTC settings can manage stable chronic diseases, treat minor acute illnesses, and avoid conditions via early detection, thus reducing emergency room...

Understanding apelin function at the molecular-level.

2010/11 • $26,105
The peptide molecule apelin is used as a messenger in the cardiovascular system, brain, and in response to blood glucose. Apelin functions by interacting with a specific receptor protein. This receptor is located in membranes of many cells in the body. As a whole, proteins found in the membranes...

Integrating Regulation of Phosphatidylcholine Metabolism with Maintenance of Cellular Phospholipid Homeostasis

2010/11 • $23,333
The human body contains up to five thousand different types of fat (lipids). Misregulation of lipid metabolism can lead to a myriad of diseases including heart disease and stroke, obesity, diabetes, and cancer. We use yeast and mammalian biochemical, molecular, genetic, cell biological, and...

Excitation-Contraction Coupling in the Aging Heart

2010/11 • $23,333
Heart disease is most common in the elderly and is a frequent cause of disability in older men and women. Still, the effect of age itself on the heart is not well understood. It is known that the ability of the heart to contract forcefully in situations such as exercise decreases with age. Past...

Activation and Inhibition of the Chemotherapy Target Cytidine 5'-Triphosphate Synthase

2010/11 • $23,333
Understanding how enzymes catalyze reactions and the precise interactions that occur between enzymes and the molecules they interact with provides us with the knowledge to guide drug development. The enzyme cytidine 5'-triphosphate (CTP) synthase promotes the formation of CTP in cells. CTP is a...

Pharmacokinetic, hemodynamic and neurohormone effects of calcium antagonists in sympathetic activation

2010/11 • $17,939
Neurohormone activation has long been considered a potential for serious adverse effect for calcium antagonists. Clinical studies have shown that the first generation calcium antagonists (CCBs), particularly the short acting nifedipine, may increase the risk of heart attacks and mortality in...

Roles of the MyD88-IRAK pathway and the TRIF-IRF pathway in the host defense against Pseudomonas aeruginosa infection

2010/11 • $17,500
Lung infection with Pseudomonas aeruginosa is a major cause of death in immune compromised individuals and cystic fibrosis patients. Mechanisms of host defense against this important bacterium are still unclear. Autophagy is derived from Greek roots: auto, meaning 'self', and phagy, 'to eat'....

Changing demographics: The oral health of our aging population

2010/11 • $14,857
Oral health is a vital aspect of overall health. Research has shown links between oral disease and chronic diseases such as diabetes and cardiovascular disease. These chronic diseases are known to increase with age but the significance of oral health is often overlooked. A recent Nova Scotia...

Biomechanical and neuromuscular characteristics during gait in moderate knee osteoarthritis: A framework for developing and evaluating noninvasive interventions

2010/11 • $10,973
Each year Canadians spend over 4.4 billion dollars on direct health care costs associated with arthritis. Knee osteoarthritis (OA) is a leading cause of chronic disability in older adults. Non-surgical/non-pharmacological management strategies such as bracing, exercise and heel wedges are...

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