University of Waterloo
Tests biomécaniques sur les tissus osseux et articulaires ainsi que sur les implants orthopédiques.
Delin Sun et 98 autres.
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses...
M. Michiardi et 13 autres.
Science
Fabian Jerzembeck et 9 autres.
In the superconductor Sr2RuO4, in-plane strain is known to enhance both the superconducting transition temperature Tc and upper critical field Hc2, but the effect of out-of-plane strain has not been studied. Here, the authors find that Hc2 is enhanced under out-of-plane strain, but Tc unexpectedly decreases.
Mieke Nys et 10 autres.
Bites by elapid snakes can result in life-threatening paralysis caused by α-neurotoxins blocking the neuromuscular nicotinic acetylcholine receptor. Here, the authors determine the cryo-EM structure of this receptor in complex with a short-chain α-neurotoxin.
Peter Eirew et 26 autres.
Gene fitness and essentiality analyses using in vivo cancer models are challenging due to multiple confounders. Here, the authors develop a quantitative approach to study CRISPR-transduced patient-derived xenografts, which they use to analyse in vivo gene fitness in breast cancers and the biological features that...
Luisa Moretto et 5 autres.
Release of the ATP hydrolysis product orthophosphate (Pi) from the myosin active site is central in force generation but is poorly understood. Here, Moretto et al. present evidence for multistep Pi-release reconciling apparently contradictory results.
Marilyn Goudreault et 6 autres.
Goudreault et al. investigate the role of Afadin downstream of RAS GTPases, substantiating this cell adhesion protein as a true RAS effector that couples its activation to cell polarity through the Scribble protein.
Yun Zhang et 9 autres.
Asteroid interiors are key to understand their formation and evolution. Here, the authors show that numerically simulated low-cohesion and low-friction structures with several high-cohesion internal zones can explain asteroid Bennu’s geophysical characteristics and the absence of the moons.
