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METHODS BASED ON FLUCTUATIONS IN CORTICAL SYNCHRONIZATION

A method of identifying a site of injury in a pediatric patient with brain injury is provided which comprises obtaining an electroencephalogram signal on the patient. The identification of phase synchrony within the signal is indicative of the site of brain injury. Electroencephalogram signals may also be used to determine prognosis of a pediatric patient in a coma in which an increase in the temporal variability of phase synchronized EEG signals over time is indicative of an improvement in...

Methods based on fluctuations in cortical synchronization

Hospital for Sick Children

A method of identifying a site of injury in a pediatric patient with brain injury is provided which comprises obtaining an electroencephalogram signal on the patient. The identification of phase synchrony within the signal is indicative of the site of brain injury. Electroencephalogram signals may also be used to determine prognosis of a pediatric patient in a coma in which an increase in the temporal variability of phase synchronized EEG signals over time is indicative of an improvement in...

BIOMARKERS FOR MALARIA

University Health Network

There is provided a method of identifying a subject having, or at risk of developing, severe or fatal malaria. Embodiments include determining the level of one or more biomarkers selected from angiopoietin-1 (ANG-1), angiopoietin-2 (ANG-2), von Willebrand factor (VWF), von Willebrand factor propeptide (VWFpp), soluble P-selectin, soluble ICAM-1 (sICAM-1), soluble endoglin, soluble FLT-1 (sFLT-1), soluble Tie-2 (sTie-2), C-Reactive Protein (CRP), procalicitonin (PCT), IP-10,...

SYSTEMS AND METHODS FOR COGNITIVE HEALTH ASSESSMENT

McMaster University

An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are...

BIOMARKERS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE

University Health Network

Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk variable for a lung transplant recipient after transplant or an EVLP outcome by measuring biomarker levels of one or more biomarkers selected from IL-6, IL-8, sTNFR1 and sTREM-1 in EVLP perfusate are described. The methods involve for example, i. obtaining one or more test EVLP perfusate samples of a donor lung; ii. determining in one or more test EVLP perfusate sample of a donor lung, a polypeptide...

SINGLE CHAIN ANTIBODIES FOR TARGETING PANCREATIC ALPHA AND BETA CELLS

McGill University

Single chain antibodies binding specifically to cell types of the islets of Langerhans are provided herein, as well as diagnostic, prognostic, theranostic and therapeutic methods using the antibodies to identify cell types of the islets of Langerhans and for identifying a change in ß cell mass via in vivo imaging, particularly for diseases related to the pancreas such as diabetes

RISK ASSESSMENT TOOL FOR PATIENTS WITH SEPSIS

McMaster University

The present invention provides a prognostic and mortality risk assessment method for patients with sepsis. The method involves measuring a combination of cell-free DNA (cfDNA), protein C, lactate, platelet count, creatinine level, and Glasgow Coma Score (GCS) and analyzing the measured values using a complementary log-log model to determine the daily and 28-day (or other fixed term) probabilities of dying for septic patients and a binomial Iogit model to distinguish septic patients from...

METHOD FOR TREATING DIABETES

McGill University

Fusion proteins binding specifically to cell types of the islets of Langerhans and delivering therapeutic or prophylactic agents are provided herein, as well as compositions thereof. Methods for treating or preventing diseases related to the pancreas such as diabetes are also disclosed. The therapeutic or prophylactic agents include Nemo-binding domain peptides and other inhibitors of NF-.kappa.B activation.

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