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AUTOROTATING UNMANNED AERIAL VEHICLE SURVEYING PLATFORM

Queen's University

The invention relates to an autorotating unmanned aerial vehicle (UAV) having a data acquisition system, and to methods of implementing, deploying, and using and analyzing data acquired by the UAV. The UAV has a payload housing including the data acquisition system and a rotor assembly including a hub that couples the rotor assembly to the payload housing such that the payload housing is suspended below the rotor assembly. The data acquisition system includes a processor and sensors for...

QUANTITATIVE PCR-BASED ENVIRONMENTAL DNA ASSAYS

University of Victoria

This application provides methods, kits, probes and primers, that can be used to analyze environmental samples, such as water samples, soil samples, and air samples. The methods and kits can include positive controls, to provide confidence in test results.

INDOOR LOCALIZATION USING CROWDSOURCED DATA

University of Toronto

Methods and systems for generating a map for indoor localization. Raw data traces from a plurality of mobile devices are merged to generate a single data graph. The raw data traces represent paths traversed by the mobile devices and include received signal strength (RSS) fingerprints associated with relative points along the paths. The data graph is matched with a predefined ground truth graph defining physical coordinates of traversable paths. A radio map is generated including both the...

DETECTION AND MONITORING OF MACROCYCLIC LACTONE RESISTANCE IN NEMATODES

McGill University

The present disclosure concerns the determination of the resistance or the susceptibility of a nematode to a macrocyclic lactone anti-helminthic based on the characterization of the Dyf-7 gene (or Dyf-7 gene ortholog) or its corresponding gene products. The present disclosure also provides tools and commercial packages for making such characterization.

INTERLEUKIN-12 POLYMORPHISMS FOR IDENTIFYING RISK FOR PRIMARY BILIARY CIRRHOSIS

University Health Network, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Primary biliary cirrhosis and related autoimmune disorders are characterized by polymorphisms in various loci including IL-12-related genes, and by reduced levels of IL- 12A transcripts. Methods useful to screen for these defects are described for use in diagnosing these conditions. Methods useful to treat subjects afflicted with these conditions are also described.

METHODS AND SYSTEMS FOR ASSESSING THE RISK OF GLAUCOMA

University of Tasmania, THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA, THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH, SOUTHERN ADELAIDE LOCAL HEALTH NETWORK, Council of the Queensland Institute of Medical Research

The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in...

IN-SILICO METHOD FOR DESIGNING A (D)-POLYPEPTIDE LIGAND

University of Toronto

A method for designing in-silico a (D)-polypeptide ligand that binds with a target is provided. The method includes providing a (L)-polypeptide ligand that binds with the target, the (L)-polypeptide ligand comprising one or more (L)-helical region; for each of the one or more (L)-helical region: identifying hotspot residues of the one or more (L)-helical region, that interact with residues of the target; and scanning a (D)-polypeptide database comprising single helix (D)-polypeptide...

SYSTEMS, METHODS, AND KITS FOR PERIPHERAL NERVE STIMULATION

University of Toronto

Nerve stimulation systems and methods are disclosed for providing modulation of nerve targets in the lower limbs typically at or below the knee. For example, transcutaneous electrical nerve stimulation (TENS), percutaneous nerve stimulation, and implantable stimulation systems and methods are disclosed for providing stimulation to the saphenous nerve (SAFN). Additionally, systems and methods are provided for co-stimulating the posterior tibial nerve (PTN) and SAFN in combination with unique...

METHODS AND TOOLS FOR PLANT PATHOGEN ASSESSMENT

Laval University

Described herein are methods, products and tools for plant pathogen assessment and management. Also described are collections, kits and packages comprising reagents (e.g. oligonucleotides) and uses thereof, for example for plant pathogen assessment. In an embodiment, the pathogen is a Phytophthora pathogen, in a further embodiment Phytophthora sojae. In an embodiment the plant is soybean.

RAS-TARGETED THERAPEUTIC

Hospital for Sick Children

Described herein are RAS-targeted therapeutics comprising a recombinant molecule of formula: x-C-y-DTA-DTB, wherein x is a polypeptide or absent; C is a cargo polypeptide comprising Ras/Rap1 -specific endopeptidase (RRSP); y comprises a polypeptide, a linker, or is absent; DTA is a diphtheria toxin enzymatic fragment comprising SEQ ID No: 26; and DTB is a diphtheria toxin translocation fragment comprising SEQ ID No: 4, wherein the DTA is linked to the DTB by a disulphide linkage. Methods and...