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Featured Opportunity

Increased RT Efficacy For Head and Neck Cancers

University Health Network

Validated genetic markers in head and neck cancers discovered as a molecular target to sensitize tumors to radiation and chemotherapy Head and neck cancer (HNC) is an area of significant unmet clinical need as traditional chemotherapy and radiation therapies provide 5 year survival rates of ~5%. This invention relates to the identification and regulation of a novel molecular target that plays an essential role in making head and neck tumors more sensitive to radiation and chemotherapy. The...
Featured Opportunity

Treatment for Reducing Respiratory Distress in COVID-19 Patients

Queen's University

A simple LMWHA diagnostic could be used as a companion diagnostic to identify responders to N-butyryl HA therapy
Featured Opportunity

Cell Lines Expressing Calcium Channel and Genetically-Encoded Calcium Indicators, Tech ID # 1128.2

University of Calgary

Voltage-gated calcium channels are important conduits for the entry of Ca2+ into numerous cell types, and consequently are major therapeutic targets for several disease states linked to ion channels. Conventional electrophysiological approaches used to study ion channels present many challenges that impede novel research and drug discoveries.
Featured Opportunity

Diagnosing Cognitive Impairment After COVID-19 Infection

Queen's University

Eye-tracking as a non-invasive tool capable of identifying COVID-19 patients at risk for neurological impairments
Featured Opportunity

In Vitro Fertilization test to increase successful pregnancy

Laval University

Description Biomarkers expressed in the cells surrounding the oocyte (e.g. cumulus and granulosa cells), rather than in the oocyte itself, have been tested as being indicative of human oocyte quality and competency to develop into fully developed individual. It is possible to obtain antral granulosa cells and cumulus cells during regular eggs recovery in human assisted reproductive therapy. These cells, normally discarded, contain information related to the oocyte maturation and quality and...
Featured Opportunity

Multi-Modal and Multi-Functional Nano-Particle

University Health Network

A novel biocompatible nanovesicle for use in multi-modal imaging of solid tumors intra-operationally and targeted drug delivery Surgery remains the main modality for treating solid tumors. Survival of cancer patients is directly correlated with surgical success in complete tumor removal during surgical resection. The major obstacle is to accurately distinguish between tumor tissue and normal tissue during surgery. Currently, tumor margins are typically assessed by the surgeon through visual...
Featured Opportunity

Flea Beetle Specific RNAi-Based Pesticides

University of Manitoba

To reduce reliance on these broad-spectrum chemical insecticides and their associated problems, reduced-risk insecticides are needed. A technology that offers the promise of a reduced risk approach to insect pest control is RNA interference (RNAi). RNAi is a method of reducing or silencing a single gene’s expression by applying double-stranded RNA (dsRNA) to the cells of most eukaryotic organisms.To mediate RNAi in invertebrates such as insects, long dsRNAs are preferred, as they can...
Featured Opportunity

Neuroprotective Small Molecule Therapeutic - MS & Optic Neuritis

Centre for Addiction and Mental Health

Our scientists have identified a protein-protein coupling between the glutamate A2 (GluA2) - α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor and the extracellular protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a novel target for the treatment of MS, optic neuritis and related indications. By characterizing the protein-protein (GluA2-GAPDH complex) interaction, we have created a novel series of small molecules that interfere with this coupling, and...
Featured Opportunity

App4Independence (A4i), www.A4i.me

Centre for Addiction and Mental Health

The App4Independence (A4i) addresses the complexity of support, isolation and relapse risk along the schizophrenia care continuum. A4i is an evidence-based, digital therapeutic intervention (DTx) (mobile app and clinician dashboard) with a regulatory pathway, patent pending features and early publications. A4i supports recovery, care coordination and community functioning while using machine learning to identify relapse risk for complex behavioral health. The first indication we are...
Featured Opportunity

Novel Selective Cyp26 Antagonists for Dermatological Diseases

Queen's University

Cyp26 inhibitor compounds treat diseases such as psoriasis, while avoiding retinoid related side effects