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App4Independence (A4i), www.A4i.me

Centre for Addiction and Mental Health

The App4Independence (A4i) addresses the complexity of support, isolation and relapse risk along the schizophrenia care continuum. A4i is an evidence-based, digital therapeutic intervention (DTx) (mobile app and clinician dashboard) with a regulatory pathway, patent pending features and early publications. A4i supports recovery, care coordination and community functioning while using machine learning to identify relapse risk for complex behavioral health. The first indication we are...
Featured Opportunity

eGuru: Mobile App for CBT

Centre for Addiction and Mental Health

eGuru is a digital health intervention to administer cognitive behavioral therapy (CBT) though a mobile app. eGuru includes a suite of tools that can address a variety of problems ranging from anger to psychotic symptoms and is based in an existing CBT based self-help intervention that has been field-tested in randomized clinical trials. The app will provide help for a variety of problems such as; anger, stress, depression, anxiety, fears and phobias, psychosis etc.

NOTCHED AIRWAY DEVICE AND USE THEREOF IN BAG-MASK VENTILATION AND ENDOTRACHEAL TUBE PLACEMENT

University of Saskatchewan

Novel airway devices and methods address complications of ventilating a patient with a mask; placing an endotracheal tube in an awake patient; and need for a bite block during flexible bronchoscopy and gastroscopy. The airway device features notches for engaging maxillary and mandibular teeth in a manner protracting the patient's mandible relative to the maxilla to open up the airway. This way, an open airway is easily maintained simply by holding the jaw closed against the device with the...

RANDOMIC VIBRATION FOR TREATMENT OF BLOOD FLOW DISORDERS

Simon Fraser University

A therapeutic device and method for use thereof for treatment of blood flow disorders is disclosed. In one embodiment, a first line emergency response system for treatment of acute thrombotic and / or vasospastic vascular obstructions via the noninvasive application of low frequency vibration with at least one, and preferably a plurality of randomly administered vibratory waveform characteristics (herein after "Randomic Vibration") is detailed. The disclosed apparatus and methods are based...

SYSTEMS AND METHODS FOR COGNITIVE HEALTH ASSESSMENT

McMaster University

An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are...

PLATFORM, DEVICE AND PROCESS FOR ANNOTATION AND CLASSIFICATION OF TISSUE SPECIMENS USING CONVOLUTIONAL NEURAL NETWORK

University Health Network

Embodiments described herein provide a platform, device and process for digital pathology that enable multi-level annotation and visualization of histopathologic slides using a modular arrangement of deep convolutional neural networks (CNNs). The CNNs can be trained using pathology images (e.g., in some cases increasing the base of data by breaking larger fields of view into smaller ones) to learn features consistent with certain pathologies. The platform can use the CNNs to visually...

SHAPE ADAPTABLE INTRAMEDULLARY FIXATION DEVICE

University of British Columbia

Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the...

T CELL-ANTIGEN COUPLER WITH Y182T MUTATION AND METHODS AND USES THEREOF

McMaster University

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

CD133-BINDING AGENTS AND USES THEREOF

University of Toronto, McMaster University

This disclosure is directed to novel CD133-binding agents. The disclosure is also directed to uses of novel CD133-binding agents for detecting CD133-expressing cells and/or quantitating levels of cellular CD133 expression, for targeting CD133-expressing cells, for decreasing levels of CD133 in CD133-expressing cells and for treating or preventing cancer.

T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS

McMaster University, TRIUMVIRA IMMUNOLOGICS USA

A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different...

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