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THEBAINE 6-O-DEMETHYLASE AND CODEINE O-DEMETHYLASE FROM PAPAVER SOMNIFERUM

Concordia University, University of Calgary

The present invention relates to gene and protein sequences for a thebaine 6-O- demethylase from Papaver somniferum and methods of use therefor. The present invention also relates to gene and protein sequences for a codeine O-demethylase from Papaver somniferum and methods of use therefor. The present invention also relates to gene and protein sequences for a protoberberine 10 O-demethylase from Papaver somniferum and methods of use therefor. In particular, systems for the recombinant...

INHIBITORS OF PROKARYOTIC GENE TRANSCRIPTION AND USES THEREOF

University of Ottawa, THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Disclosed herein are polypeptides, compositions, and methods for the treatment and/or prevention of microbial infections. In certain aspects, the disclosure provides a polypeptide derived from a bacterial RNA polymerase cofactor (e.g., alternative sigma factor σ54,) comprising at least two non-natural amino acids.

MODIFIED EXTRACELLULAR DOMAIN OF GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR (G-CSFR) AND CYTOKINES BINDING SAME

University of Victoria, Zymeworks, Provincial Health Services Authority

Described herein are methods and compositions for selective activation of cells using variant cytokine receptor and cytokine pairs, wherein the cytokine receptors comprise an extracellular domain (ECD) of granulocyte-colony stimulating factor receptor (G-CSFR). In certain embodiments, the methods and compositions described herein are useful for exclusive activation of cells for adoptive cell transfer therapy. Thus, included herein are methods of producing cells expressing variant receptors...

ANTI-ONCOLYTIC VIRUS ANTIGEN ANTIBODIES AND METHODS OF USING SAME

University of Victoria, Centre for Drug Research and Development, Provincial Health Services Authority, Admare Therapeutics Society

Provided are antibodies that specifically bind Vaccinia Virus (VV) A56 or B5 antigen. Also provided are fusion proteins and conjugates that comprise the antibodies. Pharmaceutical compositions and kits that comprise the antibodies, fusion proteins and conjugates are also provided. Aspects of the present disclosure further include methods of using the antibodies, fusion proteins and conjugates, e.g., for therapeutic purposes. In certain embodiments, provided are methods that comprise...

DATA VISUALIZATION PLATFORM FOR EVENT-BASED BEHAVIOR CLUSTERING

University of Toronto

A platform for processing event traces to generate clusters of journey maps for an interactive user display. The clustering can be implemented using a genetic process. The clustering can be implemented using a distance measures. Other clustering techniques can be used. The platform can use the clustering results to generate interactive dynamic visualizations with interactive selectable portions. The platform can integrate processing mining and journey maps to generate interactive dynamic...

SYSTEM AND METHOD FOR SOLAR-POWERED OXYGEN DELIVERY

University of Alberta

A system and method for solar-powered oxygen delivery involve producing concentrated oxygen with an oxygen concentrator powered, either directly or indirectly, with electrical energy generated by a photovoltaic cell, storing concentrated oxygen produced by the oxygen concentrator in a pillow tank at a pressure above atmospheric pressure, and allowing concentrated oxygen to discharge from the pillow tank through a distribution line to an outlet such as a facemask or nasal cannula.

IN-SILICO METHOD FOR DESIGNING A (D)-POLYPEPTIDE LIGAND

University of Toronto

A method for designing in-silico a (D)-polypeptide ligand that binds with a target is provided. The method includes providing a (L)-polypeptide ligand that binds with the target, the (L)-polypeptide ligand comprising one or more (L)-helical region; for each of the one or more (L)-helical region: identifying hotspot residues of the one or more (L)-helical region, that interact with residues of the target; and scanning a (D)-polypeptide database comprising single helix (D)-polypeptide...

POSITIONING DEVICE FOR MEDICAL DEVICES

University of Calgary

The present disclosure is directed to a positioning device for insertion into a patient. The device includes an outer sheath having an external thread on an outer surface. The device also includes a removable inner cannula for insertion into the outer sheath. The cannula has a penetrating end at its insertion end. It may also include a locking device for locking the inner cannula to the outer sheath. The device may be a pneumothorax drainage device.

MODULATION OF CYP8B1 FOR THE PREVENTION AND TREATMENT OF LIVER FIBROSIS AND METABOLIC DISORDERS

University of British Columbia

Provided are oligomers, methods, uses and pharmaceutical compositions for reducing the expression of Sterol 12-α hydroxylase (Cyp8b1 ) in a cell or tissue with an oligomer described herein in a biologically effective amount sufficient for the treatment of liver fibrosis. The oligomer may be between 4 to 49 nucleobases in length which comprises a contiguous nucleotide sequence of a total of between 4 to 49 nucleotides, wherein the contiguous nucleotide sequence is targeted to hybridize to a...

COLLAGEN-LIKE PROTEINS

University of Ottawa

Provided herein is a polypeptide encoding a modified collagen-like protein or fragment thereof, wherein the modified collagen-like protein comprises at least one of the following features: is more soluble in acidic, neutral, and/or basic solutions than a non- modified collagen like protein or fragment thereof; is stable in solution at from about 5 to about 36°C at physiologic pH; self-assembles into a triple helix in acidic, neutral, and/or basic solutions; has thermal stability that is...

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