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MONBRETIN A (MBA) SYNTHESIS USING A HETEROLOGOUS NUCLEIC ACID(S) ENCODING A MBA PATHWAY ENZYME

University of British Columbia

Provided are transgenic organisms, such as plants and plant parts, cells, and related compositions and methods for producing and monitoring the genotype for enhanced production of montbretin A and/or its precursors. For example, provided is a transgenic organism comprising at least one heterologous nucleic acid operatively linked to a promoter, wherein the heterologous nucleic acid encodes at least one enzyme in a montbretin A (MbA) metabolic pathway. The organisms can be a plant, plant...

TISSUE PROTECTIVE PEPTIDES COMPRISING A CELL PENETRATING PEPTIDE FUSED TO HEME OXYGENASE PROTEIN AND USES THEREOF

Dalhousie University

The invention provides an isolated, engineered, non-naturally occurring tissue protective protein or peptide (TPP) comprising a cell penetrating peptide (CPP) fused in frame with a heme oxygenase protein, or a derivative, variant, homolog, or analog thereof. Methods for using the isolated, engineered, non-naturally occurring tissue protective protein or peptide (TPP) include protecting or treating cells in vitro, ex vivo, or in vivo susceptible to ischemia and reperfusion injury (IRI).

METHODS OF IMPROVING THE THERAPEUTIC EFFICACY AND UTILITY OF ANTIBODY FRAGMENTS

University of Guelph

The present disclosure relates to methods and uses of improving the therapeutic efficacy and utility of antibody fragments by employing anti-epitope-tagging technologies.

THEBAINE 6-O-DEMETHYLASE AND CODEINE O-DEMETHYLASE FROM PAPAVER SOMNIFERUM

Concordia University, University of Calgary

The present invention relates to gene and protein sequences for a thebaine 6-O- demethylase from Papaver somniferum and methods of use therefor. The present invention also relates to gene and protein sequences for a codeine O-demethylase from Papaver somniferum and methods of use therefor. The present invention also relates to gene and protein sequences for a protoberberine 10 O-demethylase from Papaver somniferum and methods of use therefor. In particular, systems for the recombinant...

BORANOPHOSPHATE DERIVATIVES FOR THE TREATMENT OF OSTEOARTHRITIS

Bar-Ilan University, Laval University

The present invention provides pharmaceutical compositions and methods for treatment and management of osteoarthritis using certain dinucleotide boranophosphate derivatives or nucleoside boranophosphate derivatives. The invention further provides particular diadenosine penta(?-borano)phosphate derivative such as diadenosine 5',5''-P1,P5,a ̧ß-methylene-d,e- methylene-pentaphosphate-?-borano and di-2'-deoxyadenosine 5',5''-P1,P5,a ̧ß-methylene-d,e-methylene pentaphosphate-?-borano, and...

MIRNA INHIBITORS AND THEIR USES

SUNNYBROOK RESEARCH INSTITUTE

The invention relates to miRNA inhibitors and their use for modulation of expression of miRNA targets. In particular the invention relates to a miRNA inhibitor of a miRNA comprising at least one polynucleotide having a sequence complementary to a truncated sequence of the miRNA or sequence complementary thereto, and one or more nucleotides of a loop region of a pre-miRNA sequence from which the miRNA is generated.

METHODS FOR THE REGULATION OF THE PROSTAGLANDIN F SYNTHASE (PGFS) ACTIVITY OF AKR1B1 AND USES THEREOF

Laval University

AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH2 into PGF2a. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF2a are also provided.

COMPOSITIONS COMPRISING A GLYCYLCYCLINE AND A TYROSINE KINASE INHIBITOR FOR TREATING CANCER

THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, University Health Network

Methods, kits and compositions for treating a cancer, the method comprising administering to a subject in need thereof a glycylcycline, for example tigecycline, and a TKI, wherein the glycylcycline and the TKI are provided in a synergistic ratio.

Methods and products for inducing mucosal immunity

COLEY PHARMACEUTICAL GROUP, CPG IMMUNOPHARMACEUTICALS, LOEB HEALTH RESEARCH INSTITUTE AT THE OTTAWA HOSPITAL, Ottawa Health Research Institute, Ottawa Hospital Research Institute

The invention relates to methods and products for inducing mucosal immunity. In particular, the invention relates to the use of immunostimulatory oligonucleotides containing a CpG motif for inducing mucosal immunity. The CpG immunostimulatory oligonucleotides may be administered alone or in combination with antigen and/or with other adjuvants.

BIOMASS PROCESSING METHODS AND SYSTEMS

University of Saskatchewan

A process for producing desired compounds from biomass, including treating a lignocellulosic waste stream in some embodiments. The waste stream is conditioned under acidic or basic conditions, and is then treated in a catalytic reaction step using a transition metal catalyst and an oxidant. The transition metal catalyst can be an iron-based nanoparticulate catalyst. In some embodiments, useful compounds such as lignin, crystalline cellulose and various platform chemicals are produced from...