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Assessment of risk for colorectal cancer

Cancer Care Ontario, McGill University

Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).

Assessment of risk for colorectal cancer

Cancer Care Ontario, McGill University

Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).

USES OF AND METHODS OF TREATMENT WITH CYSTATHIONINE

THE REGENTS OF THE UNIVERSITY OF COLORADO

The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. In one embodiment, a cystathionine synthesis inhibitor is administered to increase tumor cell apoptosis and/or increase the efficacy of chemo therapeutic treatment. More particularly, cystathionine can protect cells against toxin- induced cellular...

SYSTEMS METHODS AND COMPOSITIONS FOR PREDICTING METASTASIS IN BLADDER CANCER

GenomeDx Biosciences, University of British Columbia

The present invention relates to methods, systems and kits for the diagnosis, prognosis and the determination of cancer progression in a subject having cancer. The invention also provides methods, systems and kits for treating cancer in a subject. The methods, systems and kits comprise expression- based analysis of biomarkers. Further disclosed herein, in certain instances, are probe sets for use in assessing a cancer status in a subject. Further disclosed herein are classifiers for...

METHODS AND SYSTEMS FOR ASSESSING THE RISK OF GLAUCOMA

SOUTHERN ADELAIDE LOCAL HEALTH NETWORK, THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH, THE FLINDERS UNIVERSITY OF SOUTH AUSTRALIA, University of Tasmania

The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in...

NOVEL NETRIN DERIVATIVES AND USES THEREOF

McGill University

Netrin proteins and their receptors regulate cell and axon migration, and are implicated in tissue morphogenesis, tumorigenesis and angiogenesis. Deregulation of mechanisms that control cell motility plays a key role in tumor progression by promoting tumor cell dissemination. Unwanted neovascularization also contributes to tumor progression and metastasis and to ocular diseases which are a leading cause of blindness. Here, we describe novel netrin-derived polypeptides and fragments or...

cDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF

McGill University

The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.

BACTERIAL COMPOSITIONS AND METHODS OF USE THEREOF

University of British Columbia

The present invention relates to bacterial compositions and methods of use thereof. The bacterial compositions may include two or more bacteria of the genera Faecalibacterium, Lachnospira, Veillonella or Rothia. The bacterial compositions may be used in treating gut dysbiosis, asthma, allergy, or atopy, or altering the gut microbiota, or populating the gastrointestinal tract, in a subject in need thereof.

T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS

McMaster University, TRIUMVIRA IMMUNOLOGICS USA

A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different...

Bacterial virulence factors and uses thereof

Universidad Nacional Autonoma de Mexico, University of British Columbia

The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.