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Select: All | None

Select: All | None

METHOD OF MODULATING IRE1 ACTIVITY

New York University, Sinai Health System

The present invention is directed to compositions and methods of modulating IRE1 RNase activity comprising contacting said IRE1 with an agent that binds to the Q site or that inhibits the binding of a ligand to the Q site, wherein the Q site is a ligand binding site located at the dimer interface of the KEN domains of the IRE1 oligomer. The invention is also directed to compositions and methods of modulating the unfolded protein response in the cell.

USE OF GANGLIOSIDE TO DECREASE PROPAGATION OF MALIGNANT PROSTATE CELLS

University of Alberta

Uses of exogenous ganglioside to inhibit the propagation of prostate cancer cells is provided. Gangliosides regulate many cellular processes including cell death. The present disclosure assesses the role of ganglioside in prostate cell growth. Malignant prostate (PC-3) and control (RWPE-1) cells can be cultured with or without ganglioside treatment. Cells can be assayed for differences in cell growth. Supplementation with ganglioside (GD3) can decrease growth of PC-3 cells by 30% compared to...

METHODS TO TREAT VISUAL IMPAIRMENT

Dalhousie University, Massachusetts Institute of Technology

Amblyopia is a prevalent form of visual impairment that generally arises during infancy and early childhood when inputs to the visual cortex form the two eyes are poorly balanced. Disclosed herein are methods involving retinal inactivation of at least one retina to treat visual impairment in the form of amblyopia or other conditions.

ACTIVE PHAGE-BASED INKS, METHODS OF PRINTING ON MATERIALS AND PHAGE-BASED BIOACTIVE

University of Guelph

An active phage bio-ink composition and phage-based bioactive paper, wherein the phage is oriented and immobilized at the paper surface through heads, with the phage tail fibers free to capture target bacterial pathogens.

STRUCTURE DEFECT DETECTION USING MACHINE LEARNING ALGORITHMS

University of Manitoba

Structure defect detection is performed using computer-implemented arrangements employing machine learning algorithms in the form of neural networks. In one arrangement, a convolutional neural network is trained using a database of images formed to optimize accuracy of the convolutional neural network to detect, for example, a crack in a concrete surface. A two-stage scanning process each performing a plurality of scans of a test image is incorporated in the foregoing arrangement of...

SCREENING FOR NITROGEN FIXATION

University of Guelph

An essentially glutamine-free medium comprising a whole-cell glutamine biosensor, comprising a glutamine auxotrophic E.coli and a Lux reporter gene, for detecting glutamine in an analyte. The medium is useful in methods to detecting, screening, identifying and selecting nitrogen-fixing microbes and in methods of determining the nitrogen state of plants, plant products and soil.

METHODS AND APPARATUS FOR FLOW-CONTROLLED WETTING

University of British Columbia

Methods of determining a first position at which a dispersed phase droplet wets a surface of a channel are provided herein. The methods include immersing the dispersed phase droplet in a continuous phase fluid, wherein the continuous phase fluid is immiscible with the dispersed phase droplet, subsequently flowing the dispersed phase droplet in the continuous phase through the channel at a dispersed phase droplet velocity, wherein the dispersed phase droplet is separated from the surface by a...

DIAGNOSIS AND TREATMENT OF MYCOBACTERIA INFECTIONS

University of Alberta

The invention provides isolated, purified, recombinant receptor binding proteins Gp- 6, Gp-10 and Gp-31 from mycobacterium phage L5, and methods for producing these recombinant receptor binding proteins. The invention also provides the use of recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31, as probes for the identification and diagnosis of mycobacterium infections and conditions caused by mycobacterium. Further provided by the invention are methods of targeting...

METHODS FOR REMOVING MERCURY CONTAMINANT FROM AQUEOUS SOLUTIONS, AND BIOREACTORS THEREFOR

University of Ottawa

Provided herein are methods for removing mercury contaminant from an aqueous solution, the methods including: providing an aqueous solution, the aqueous solution being contaminated with at least trace amounts of an oxidized mercury species; culturing a photoheterotrophic or fermentative heterotrophic bacteria in the aqueous solution under anaerobic conditions in which the bacteria reduce the oxidized mercury species to elemental mercury (Hg0), wherein the bacteria comprises one or more...

METHODS AND SYSTEMS FOR PREDICTING MISFOLDED PROTEIN EPITOPES

University of British Columbia

A method and system to identify an epitope unique to a misfolded form of a protein is provided. Sets of one or more amino acid residues are selected from a model representing the structure of the protein; the free energy of unfolding of each set is determined; and the epitope is identified from the sets having a total probability of unfolding above a minimum probability or a free energy of unfolding below a minimum energy. In other aspects, the invention provides for the use of epitopes...

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