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Select: All | None

Select: All | None

HYBRID-CAPTURE SEQUENCING FOR DETERMINING IMMUNE CELL CLONALITY

University Health Network

In an aspect, there is provided, a method of capturing a population of T-Cell receptor and/or immunoglobulin sequences with variable regions within a patient sample, said method comprising: extracting/preparing DNA fragments from the patient sample; ligating a nucleic acid adapter to the DNA fragments, the nucleic acid adapter suitable for recognition by a pre-selected nucleic acid probe; capturing DNA fragments existing in the patient sample using a collection of nucleic acid hybrid capture...

POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPOUND-INDUCED OTOTOXICITY

University of British Columbia

Methods of determining a subj ecf s ototoxicity risk from administration of platmum-coordmatmg compounds having an ototoxicity risk, methods of administering a platmum-coordmatmg compound having an ototoxicity risk and oligonucleotides, peptide nucleic acids, arrays and addressable collections for performing embodiments of the methods are provided herein.

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