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Select: All | None

Select: All | None

METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY

University Health Network

The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

ANTIBODIES TO L-TYPE VOLTAGE GATED CHANNELS AND RELATED METHODS

BioMmune Technologies

Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.

SALMONELLA VACCINE PROTEINS

University of British Columbia

Compositions and methods for the treatment or prevention of Gram negative bacterial, such as Salmonella spp. infection, in a vertebrate subject are provided. The methods provide administering a composition to the vertebrate subject in an amount effective to reduce or eliminate the Salmonella spp. bacterial infection and/or induce an immune response to the protein. Methods for the treatment or prevention of Salmonella spp. infection in a vertebrate are also provided. Other compositions and...

SALMONELLA VACCINE PROTEINS

University of British Columbia

Compositions and methods for the treatment or prevention of Gram negative bacterial, such as Salmonella spp. infection, in a vertebrate subject are provided. The methods provide administering a composition to the vertebrate subject in an amount effective to reduce or eliminate the Salmonella spp. bacterial infection and/or induce an immune response to the protein. Methods for the treatment or prevention of Salmonella spp. infection in a vertebrate are also provided.

METHODS OF DIAGNOSING ASTHMA

University of Manitoba

A method of detecting a risk for or presence of asthma in a subject. The method comprises obtaining a biological sample comprising human airway smooth muscle cells from a subject and testing the biological sample for the presence of a pentraxin-3 (PTX3) polypeptide. The presence and/or quantity of PTX3 polypeptide in the biological sample correlates with the risk for or presence of asthma in the subject.

MYCOPLASMA BOVIS VACCINES AND USES THEREOF

INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI), KENYA AGRICULTURE AND LIVESTOCK RESEARCH ORGANIZATION (KALRO), University of Saskatchewan

Mycoplasma bovis antigens for use in subunit vaccine compositions to elicit immune responses against M. bovis, polynucleotides encoding therefor, and use of said compositions to prevent Mycoplasma bovis infections.

NLRP6 INFLAMMASOME INTESTINAL EPITHELIUM MUCUS SECRETION

University of British Columbia, Weizmann Institute of Science, Yale University

The present invention provides a composition and method for treating or preventing a disease or disorder associated with intestinal microbiota comprising a modulator of intestinal epithelium mucin secretion.

DIAGNOSIS OF RESTENOSIS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

University of Saskatchewan

The present invention relates to compounds, methods and/or kits for determining and/or predicting and/or treating restenosis in a patient. The patient is a subject suffering from acute coronary syndrome (ACS). The compounds, methods and kits for the diagnosis or prediction of restenosis in the subject relates to the levels of sRAGE, TNF-a, sVCAM-1 or AGE in a serum sample from said subject. Treatment involves administration of agents that increases the amount of sRAGE in a subject and/or...

METHODS FOR PRODUCING SALMONELLA O- ANTIGEN CAPSULES, COMPOSITIONS AND USES THEREOF

University of Saskatchewan

Methods of purifying O-Ag capsules from an S. enterica NTS serovar, wherein the O- Ag capsule is substantially free of co-expressed cellulose and LPS, are described, as are immunogenic compositions comprising the O-Ag capsules and methods for treating, preventing and diagnosing Salmonella infections. Also described are constructs and methods for producing S. enterica NTS serovar mutants which over-express the O-Ag capsule.

METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING SHIGA TOXIN-PRODUCING ESCHERICHIA COLI INFECTION

Bioniche Life Sciences, BIONICHE LIFE SCIENCES INC. A BODY CORPORATE PURSUANT TO THE LAWS OF CANADA, University of Saskatchewan

Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least...

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