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CARBON AND NITROGEN-REGULATING GENE AND PROTEIN AND MODULATION THEREOF

University of Guelph

The present invention relates to a nitrogen-regulated GATA transcription factor gene required for sugar and nitrogen accumulation and the modulation of the expression of this gene to modulate a characteristic in a plant. The GATA transcription factor of the present invention is involved in regulating sugar and nitrogen accumulation in plants. Increased expression of this or substantially similar genes can produce plants with improved nitrogen utilization and increased yield and increased...

NANOPARTICLE COMPOSITIONS FOR SUSTAINED THERAPY

University of Calgary

This disclosure provides compositions and methods for promoting the formation, expansion and recruitment of TR1 cells and/or B cells in an antigen-specific manner and treating diseases and disorders in a subject in need thereof.

PEPTIDIC TGF-BETA ANTAGONISTS

McGill University

The present invention provides peptidic TGF-β antagonists capable of inhibiting TGF- β signaling and disrupting the biochemical events that promote fibrosis and the epithelial- mesenchymal transition. The peptidic TGF-β antagonist may contain from 11 to 28 amino acid residues (for instance, may consist of from 12 to 16 amino acid residues) and may have the following structure (II): NH2' ETWIWLDTNMG - Xaa1 - Y 'COOH (II) wherein Xaa1 is any amino acid and Y is a peptide having from 0 to 9...

ANTIBODIES WITH HIGH AFFINITY FOR AKLOTHO

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, University of Toronto

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a aKlotho polypeptide, optionally a folded aKiotho or optionally with a dissociation constant (KD) of about 2 nM or less, as measured by competitive ELISA assay, methods 0 of making and using to diagnose kidney diseases.

TRANSGENIC EXPRESSION OF ACYL-CO-A BINDING PROTEINS IN PLANTS

SEMBIOSYS GENETICS, University of Alberta

Disclosed are methods for modification of fatty acid composition and/or seed oil content in plants. In particular are methods to over-express acyl-CoA binding proteins (ACBPs) within the cells of developing seeds are provided. Over-expressing ACBPs under the control of a seed preferred promoter increases polyunsaturated fatty acid (PUFA) levels as compared to wild-type controls.

CRISPR/CAS9 SYSTEM AND USES THEREOF

Laval University

Methods and products are described herein for the modification of nucleic acids using a CRISPR/Cas9 system. Also described herein are uses of such methods and products for the modification of a target nucleic acid in a cell, in vitro or in vivo. Such methods and products may also be used for prevention or treatment of a condition associated with a target polynucleotide.

CNS chloride modulation and uses thereof

Laval University

Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or...

METHODS AND COMPOSITIONS OF ANTI-CRISPR PROTEINS FOR USE IN PLANTS

DUPONT NUTRITION BIOSCIENCES APS, Laval University

Methods and compositions are provided for the use of anti-CRISPR (ACR) proteins in plants, including modulation of Cas endonuclease activity, improvement of frequency of homologous recombination, control of Cas endonuclease activity during various cell cycles, spatial and/or temporal regulation of Cas endonuclease activity in plants, usage in gene activation or repression, as well as reduction of off-target polynucleotide cleavage.

ABC TREPENOID TRANSPORTERS AND METHODS OF USING THE SAME

University of British Columbia

Provided herein are ATP-binding cassette transporters (ABC transporters). More specifically, the present disclosure relates to ABC terpenoid transporters, nucleic acid sequences, amino acids, proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof.

ALTERNATIVE SPLICING MODULATORS AND SPLICE VARIANTS AND THEIR USE IN THE CONTROL AND DETECTION OF PLURIPOTENCY AND DIFFERENTIATION

University of Toronto

Nucleotide sequences encoding novel splice variants of FOXP1, proteins encoded by the novel splice variants and antibodies thereto are disclosed. In addition, methods are described for maintaining a population of homogenous self-renewing and pluripotent stem cells, suppressing stem cell differentiation, and reprogramming somatic cells into pluripotent stem cells comprising the use of the novel splice variants. Also disclosed are modulators of alternative splicing such as MBNL1 and MBNL2 and...