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Select: All | None

Select: All | None

SYNTHETIC EPIGALLOCATECHIN GALLATE (EGCG) ANALOGS

Hong Kong Polytechnic University, McGill University, Wayne State University

Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.

METHODS OF IMPROVING THE THERAPEUTIC EFFICACY AND UTILITY OF ANTIBODY FRAGMENTS

University of Guelph

The present disclosure relates to methods and uses of improving the therapeutic efficacy and utility of antibody fragments by employing anti-epitope-tagging technologies.

INNOCUOUS, STRUCTURED SCAFFOLDS FOR STRUCTURE-BASED AMYLOID DISEASE VACCINES AND ANTIGENS

University of Alberta

The present disclosure relates generally to polypeptides, which may be used of the treatment of neurological diseases or disorders.

METHODS AND COMPOSITIONS IN DIAGNOSIS OF CHRONIC FATIGUE SYNDROME/MYALGIC ENCEPHALOMYELITIS

University of Alberta

The present disclosure provides methods and compositions that find use in facilitating a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in a subject. The methods and compositions involve measurement of at least one of proteins: IL-16, IL-7, VEGF, CXCL9, CX3CL1, CCL24, CCL19, and CCL11 in a body fluid sample of a subject suspected of having CFS/ME. Levels of one or more of the aforementioned proteins can be used to facilitate a diagnosis of a CFS/ME and/or confirm a...

HEPATITIS C VIRUS E1/E2 HETERODIMERS AND METHODS OF PRODUCING SAME

University of Alberta

The present disclosure provides affinity tagged heterodimeric polypeptides comprising a hepatitis C virus (HCV) El polypeptide and an HCV E2 polypeptide, where one or both of the El and E2 polypeptides comprises an affinity tag. The present disclosure provides a method of producing an affinity tagged E1/E2 heterodimer of the present disclosure. The present disclosure provides methods of producing untagged HCV E1/E2 heterodimers. The present disclosure provides HCV E1/E2 heterodimers,...

PANCREATIC ENDOCRINE PROGENITOR CELL THERAPIES FOR THE TREATMENT OF OBESITY AND TYPE 2 DIABETES (T2D)

Petunia Resources, University of British Columbia

Provided herein are therapies, and methods using that therapy, in the treatment of one or more of Type 2 diabetes (T2D), obesity, glucose intolerance and insulin resistance or to control weight gain in subjects. In particular, the subject may be candidates for treatment with one or more small molecule anti-diabetic drugs and the therapy may include implanting a population of pancreatic endocrine progenitor cells into the subject, where the cells are allowed to mature in vivo to produce a population.

MICROFLUIDIC CELL TRAP AND ASSAY APPARATUS FOR HIGH-THROUGHPUT ANALYSIS

University of British Columbia

Microfluidic devices are provided for trapping, isolating, and processing single cells. The microfluidic devices include a cell capture chamber having a cell funnel positioned within the cell capture chamber to direct a cell passing through the cell capture chamber towards one or more a cell traps positioned downstream of the funnel to receive a cell flowing. The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of...

DEGRADATION OF HYDROCARBONS USING FILAMENTOUS FUNGUS

University of Saskatchewan

The use of a filamentous fungus for degrading hydrocarbons and environmental toxins is provided. The filamentous fungus can be Trichoderma harzianum strain TSTh20-1.

EXOSOME PACKAGING OF NUCLEIC ACIDS

University of Ottawa

A method for preparing exosomes or exosome-like vesicles packaged with a nucleic acid of interest is provided. In certain embodiments, the method may comprise: introducing into an exosome-producing cell a nucleic acid construct comprising the nucleic acid sequence of interest incorporated in a pre-miR-451 structural mimic, and allowing the cell to produce exosomes. Nucleic acid constructs, compositions, and uses thereof are also provided.

CELL WALL DECONSTRUCTION ENZYMES OF MALBRANCHEA CINNAMOMEA AND USES THEREOF

Concordia University, DSM IP ASSETS B.V

The present invention relates to a novel process for degrading biomass or pretreated biomass to sugars wherein an enzyme is used comprising: a. a polypeptide comprising an amino acid sequence of any one of SEQ ID NOs: 5 or 6; b. a polypeptide comprising an amino acid sequence that is at least 70%, preferably at least 80%, more preferably at least 90%, even more preferably at least 95%, 96%, 97%, 98% or 99% amino acid sequence identity to the polypeptide defined in (a); c. a polypeptide...

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